Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice.

PubWeight™: 1.48‹?› | Rank: Top 4%

🔗 View Article (PMC 3163952)

Published in J Clin Invest on August 15, 2011

Authors

Jie Li1, Kathleen M Horak, Huabo Su, Atsushi Sanbe, Jeffrey Robbins, Xuejun Wang

Author Affiliations

1: Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark Street, Lee Medical Building, Vermillion, South Dakota 57069, USA.

Articles citing this

In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol (2011) 1.80

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins. Circulation (2013) 1.62

Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload. J Mol Cell Cardiol (2015) 1.41

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in mice. Circ Res (2012) 1.15

Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol (2013) 1.12

Proteasome functional insufficiency in cardiac pathogenesis. Am J Physiol Heart Circ Physiol (2011) 1.11

Exercise training restores cardiac protein quality control in heart failure. PLoS One (2012) 1.06

Posttranslational modification and quality control. Circ Res (2013) 1.06

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia. Blood (2012) 1.05

Ubiquitin receptors and protein quality control. J Mol Cell Cardiol (2012) 1.04

Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria. Circ Res (2012) 1.02

Regulating the 20S proteasome ubiquitin-independent degradation pathway. Biomolecules (2014) 1.02

Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes (2012) 1.00

Deciphering preferential interactions within supramolecular protein complexes: the proteasome case. Mol Syst Biol (2015) 1.00

MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury. EMBO Mol Med (2012) 0.99

The ubiquitin proteasome system in human cardiomyopathies and heart failure. Am J Physiol Heart Circ Physiol (2013) 0.99

p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress. Trends Cardiovasc Med (2011) 0.98

The ubiquitin-proteasome system and cardiovascular disease. Prog Mol Biol Transl Sci (2012) 0.93

Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human. Mol Cell Proteomics (2013) 0.91

Recent progress in research on molecular mechanisms of autophagy in the heart. Am J Physiol Heart Circ Physiol (2014) 0.91

The ubiquitin proteasome system and myocardial ischemia. Am J Physiol Heart Circ Physiol (2012) 0.90

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice. Circ Heart Fail (2013) 0.90

Protein quality control and metabolism: bidirectional control in the heart. Cell Metab (2015) 0.90

Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Sci Rep (2013) 0.89

The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta (2014) 0.88

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circ Res (2014) 0.87

Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics. Am J Physiol Heart Circ Physiol (2012) 0.87

HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivo. PLoS One (2012) 0.86

Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance. PLoS One (2015) 0.86

Targeting the ubiquitin-proteasome system in heart disease: the basis for new therapeutic strategies. Antioxid Redox Signal (2014) 0.85

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Am J Physiol Heart Circ Physiol (2013) 0.85

Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. PLoS One (2013) 0.84

Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoKATP in Energy Homeostasis. Oxid Med Cell Longev (2015) 0.82

Chaperones: needed for both the good times and the bad times. Philos Trans R Soc Lond B Biol Sci (2013) 0.82

Clarifying the cardiac proteasome paradox: protein quality control. Circ Res (2012) 0.81

The COP9 signalosome and cullin-RING ligases in the heart. Am J Cardiovasc Dis (2015) 0.81

NEDD8 Ultimate Buster 1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins. J Biol Chem (2015) 0.81

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity. Circ Res (2015) 0.81

Proteotoxicity and cardiac dysfunction. Circ Res (2015) 0.81

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner. J Mol Cell Cardiol (2014) 0.78

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity. Sci Rep (2015) 0.78

Repeated intermittent administration of a ubiquitous proteasome inhibitor leads to restrictive cardiomyopathy. Eur J Heart Fail (2013) 0.78

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy. J Mol Cell Cardiol (2016) 0.78

Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PLoS One (2013) 0.78

Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med (2013) 0.78

Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival. J Cell Sci (2016) 0.77

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes. Front Biosci (Landmark Ed) (2016) 0.76

Ubiquitin and ubiquitin-like proteins in cardiac disease and protection. Curr Drug Targets (2015) 0.75

Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil. Future Cardiol (2015) 0.75

The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation. Evid Based Complement Alternat Med (2014) 0.75

Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations. Mol Cell Proteomics (2016) 0.75

Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent Manner. Circ Heart Fail (2016) 0.75

Alterations in the ubiquitin proteasome system in persistent but not reversible proteinuric diseases. J Am Soc Nephrol (2014) 0.75

Proteostasis in cardiac health and disease. Nat Rev Cardiol (2017) 0.75

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux. J Mol Cell Cardiol (2017) 0.75

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure. Circ Heart Fail (2017) 0.75

Articles cited by this

Impairment of the ubiquitin-proteasome system by protein aggregation. Science (2001) 11.51

Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell (2010) 4.45

Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell (2007) 3.54

Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res (2003) 3.16

Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol (2010) 2.52

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice. Circ Res (2001) 2.51

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res (2005) 2.49

Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell (2007) 2.38

Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A (2004) 2.32

Autophagy and p62 in cardiac proteinopathy. Circ Res (2011) 2.24

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function. Proc Natl Acad Sci U S A (1999) 2.18

Heart failure and protein quality control. Circ Res (2006) 2.15

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. FASEB J (2005) 2.13

Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. J Biol Chem (2001) 1.97

Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy. Circulation (2008) 1.95

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res (2010) 1.93

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes. J Mol Cell Cardiol (2006) 1.93

Mouse model of desmin-related cardiomyopathy. Circulation (2001) 1.84

Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis. J Biol Chem (2000) 1.83

Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res (2010) 1.78

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation (2005) 1.72

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. FASEB J (2005) 1.68

Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII. Nat Immunol (2004) 1.68

Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68

Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta. EMBO J (2001) 1.65

Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease. J Clin Invest (2009) 1.63

The ubiquitin-proteasome system in cardiac dysfunction. Biochim Biophys Acta (2008) 1.53

Proteasome activator 11S REG or PA28: recombinant REG alpha/REG beta hetero-oligomers are heptamers. Biochemistry (1999) 1.49

Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies. Circulation (2010) 1.49

Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem (1997) 1.47

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress. FASEB J (2010) 1.40

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res (2009) 1.36

Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. Circ Res (2010) 1.34

Impaired immunoproteasome assembly and immune responses in PA28-/- mice. Science (1999) 1.29

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice. Circ Res (2010) 1.24

Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol Cell Biol (2000) 1.18

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart. Am J Physiol Heart Circ Physiol (2009) 1.17

Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res (2010) 1.17

Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy. J Mol Biol (2008) 1.15

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. J Biol Chem (2007) 1.12

Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation (2010) 1.08

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28. Eur J Biochem (2000) 1.02

The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications. Cell Immunol (2008) 1.00

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy. J Am Coll Cardiol (2010) 0.92

Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion. Circ Res (2010) 0.92

Heterogeneous cardiac proteasomes: mandated by diverse substrates? Physiology (Bethesda) (2011) 0.85

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06

Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci U S A (2006) 4.71

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53

PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50

Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res (2003) 3.16

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest (2007) 3.13

Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res (2005) 2.67

Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59

Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res (2006) 2.59

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res (2005) 2.49

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49

Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab (2012) 2.48

Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc Natl Acad Sci U S A (2006) 2.46

Phenotyping hypertrophy: eschew obfuscation. Circ Res (2003) 2.32

Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A (2004) 2.32

Autophagy and p62 in cardiac proteinopathy. Circ Res (2011) 2.24

Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest (2007) 2.23

Impact of beta-myosin heavy chain expression on cardiac function during stress. J Am Coll Cardiol (2004) 2.17

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol (1985) (2002) 2.15

Heart failure and protein quality control. Circ Res (2006) 2.15

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin. FASEB J (2005) 2.13

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12

Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circ Res (2007) 1.95

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovasc Res (2010) 1.93

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes. J Mol Cell Cardiol (2006) 1.93

Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem (2008) 1.75

With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. J Mol Cell Cardiol (2008) 1.74

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation (2005) 1.72

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. J Mol Cell Cardiol (2006) 1.71

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts. FASEB J (2005) 1.68

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins. Circulation (2013) 1.62

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61

β-arrestin1-biased β1-adrenergic receptor signaling regulates microRNA processing. Circ Res (2013) 1.59

Analysis of myosin heavy chain functionality in the heart. J Biol Chem (2003) 1.57

Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation (2012) 1.56

Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation (2007) 1.55

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer (2009) 1.55

Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ Res (2011) 1.53

Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res (2009) 1.52

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation (2009) 1.52

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J Clin Invest (2009) 1.51

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction. Circulation (2005) 1.50

Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation (2008) 1.49

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2005) 1.49

Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest (2007) 1.48

Retracted Factors behind negative attitudes toward cadaveric organ donation: a comparison between medical and non-medical students in China. Transplantation (2014) 1.47

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. J Biol Chem (2009) 1.47

A thrombospondin-dependent pathway for a protective ER stress response. Cell (2012) 1.45

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes. Am J Physiol Heart Circ Physiol (2004) 1.44

Physiological levels of ATP negatively regulate proteasome function. Cell Res (2010) 1.44

In vivo and in vitro analysis of cardiac troponin I phosphorylation. J Biol Chem (2004) 1.43

Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest (2013) 1.41

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. J Neurosci (2008) 1.41

Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. J Mol Cell Cardiol (2011) 1.40

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress. FASEB J (2010) 1.40

Recent progress and understanding of the molecular mechanisms of the rice-Magnaporthe oryzae interaction. Mol Plant Pathol (2010) 1.38

The efficacy of isotonic and hypotonic intravenous maintenance fluid for pediatric patients: a meta-analysis of randomized controlled trials. Pediatr Emerg Care (2015) 1.38

Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). J Mol Biol (2011) 1.37

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res (2009) 1.36

Anti-clumping factor A immunoglobulin reduces the duration of methicillin-resistant Staphylococcus aureus bacteremia in an experimental model of infective endocarditis. Antimicrob Agents Chemother (2003) 1.35

Physiological growth synergizes with pathological genes in experimental cardiomyopathy. Circ Res (2004) 1.34

COP9 signalosome regulates autophagosome maturation. Circulation (2011) 1.32

AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res (2003) 1.31

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone. J Biol Chem (2008) 1.31

Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation (2006) 1.30

Application of MODIS satellite data in monitoring water quality parameters of Chaohu Lake in China. Environ Monit Assess (2008) 1.30

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife (2013) 1.28

Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling. Proc Natl Acad Sci U S A (2004) 1.28

The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function. J Mol Cell Cardiol (2006) 1.26

Desmin-related cardiomyopathy: an unfolding story. Am J Physiol Heart Circ Physiol (2011) 1.24

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice. Circ Res (2010) 1.24

Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Circ Res (2007) 1.23

Alpha B-crystallin suppresses pressure overload cardiac hypertrophy. Circ Res (2008) 1.23

Protein quality control and degradation in cardiomyocytes. J Mol Cell Cardiol (2008) 1.22

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A (2008) 1.21

Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp Cell Res (2006) 1.19

Signaling and myosin-binding protein C. J Biol Chem (2011) 1.18

Molecular mechanics of mouse cardiac myosin isoforms. Am J Physiol Heart Circ Physiol (2002) 1.17

Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest (2009) 1.17

Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes. Am J Physiol Heart Circ Physiol (2006) 1.16