Published in Nature on June 29, 2006
The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci (2009) 8.38
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med (2009) 5.50
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci (2008) 3.24
100 years and counting: prospects for defeating Alzheimer's disease. Science (2006) 3.24
Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol (2009) 2.98
Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci U S A (2010) 2.52
The stem cell potential of glia: lessons from reactive gliosis. Nat Rev Neurosci (2011) 2.49
Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice. Proc Natl Acad Sci U S A (2011) 2.09
Reactive gliosis and the multicellular response to CNS damage and disease. Neuron (2014) 2.08
Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc (2009) 1.88
Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci U S A (2009) 1.82
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1. Hum Mol Genet (2012) 1.80
Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci (2009) 1.80
Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Mol Ther (2007) 1.76
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc Natl Acad Sci U S A (2013) 1.70
Adult neural stem cells in the mammalian central nervous system. Cell Res (2009) 1.64
Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys (2012) 1.55
Stem cells for ischemic brain injury: a critical review. J Comp Neurol (2009) 1.53
Nanotopography influences adhesion, spreading, and self-renewal of human embryonic stem cells. ACS Nano (2012) 1.47
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. PLoS One (2007) 1.45
Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol (2011) 1.45
Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila. Cell Adh Migr (2009) 1.42
Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions. Neural Regen Res (2016) 1.40
Assessment of stromal-derived inducing activity in the generation of dopaminergic neurons from human embryonic stem cells. Stem Cells (2008) 1.37
Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment. PLoS One (2007) 1.33
Biomaterials approach to expand and direct differentiation of stem cells. Mol Ther (2007) 1.24
Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity. PLoS One (2012) 1.20
In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage (2011) 1.18
Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci U S A (2009) 1.18
Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev (2010) 1.15
Epigenetic mechanisms regulating fate specification of neural stem cells. Philos Trans R Soc Lond B Biol Sci (2008) 1.13
Emerging subspecialties: neurorehabilitation: training neurologists to retrain the brain. Neurology (2008) 1.13
Current progress of RNA aptamer-based therapeutics. Front Genet (2012) 1.12
Rewiring the injured CNS: lessons from the optic nerve. Exp Neurol (2007) 1.11
In vivo tracking of human neural stem cells with 19F magnetic resonance imaging. PLoS One (2011) 1.09
Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain. J Exp Med (2011) 1.09
Stem cells in clinical practice: applications and warnings. J Exp Clin Cancer Res (2011) 1.06
Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS One (2011) 1.06
Recent therapeutic strategies for spinal cord injury treatment: possible role of stem cells. Neurosurg Rev (2012) 1.04
Derivation of neural stem cells from mesenchymal stemcells: evidence for a bipotential stem cell population. Stem Cells Dev (2008) 1.02
Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions. J Clin Invest (2011) 1.01
Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice. Front Integr Neurosci (2011) 1.00
Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus (2015) 1.00
Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model. PLoS One (2009) 1.00
Dopamine systems in the forebrain. Adv Exp Med Biol (2009) 1.00
The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease. Cell Adh Migr (2011) 1.00
Multifaceted role of matrix metalloproteinases (MMPs). Front Mol Biosci (2015) 0.97
Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors. Curr Mol Med (2012) 0.96
Controlling differentiation of neural stem cells using extracellular matrix protein patterns. Small (2010) 0.96
Behavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus. J Neurosci Res (2008) 0.96
Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis. EMBO J (2014) 0.96
Age-related cognitive decline: can neural stem cells help us? Aging (Albany NY) (2012) 0.93
Neural stem cell specific fluorescent chemical probe binding to FABP7. Proc Natl Acad Sci U S A (2012) 0.92
Stem cell therapy for acute cerebral injury: what do we know and what will the future bring? Curr Opin Neurol (2013) 0.91
Magnetic resonance imaging and fluorescence labeling of clinical-grade mesenchymal stem cells without impacting their phenotype: study in a rat model of stroke. Stem Cells Transl Med (2012) 0.91
In situ genetic analysis of cellular chimerism. Nat Med (2009) 0.90
Neural stem cells and strategies for the regeneration of the central nervous system. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.90
Expansion of embryonic and adult neural stem cells by in utero electroporation or viral stereotaxic injection. J Vis Exp (2012) 0.90
MRI/SPECT/Fluorescent Tri-Modal Probe for Evaluating the Homing and Therapeutic Efficacy of Transplanted Mesenchymal Stem Cells in a Rat Ischemic Stroke Model. Adv Funct Mater (2015) 0.90
Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons. Stem Cells Dev (2014) 0.89
Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review. J Adv Res (2013) 0.88
Recent preclinical evidence advancing cell therapy for Alzheimer's disease. Exp Neurol (2012) 0.88
Stem and progenitor cells for neurological repair: minor issues, major hurdles, and exciting opportunities for paracrine-based therapeutics. J Cell Biochem (2011) 0.87
Immunological properties of embryonic and adult stem cells. World J Stem Cells (2010) 0.87
Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides. Biomaterials (2010) 0.87
Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations. Front Cell Neurosci (2012) 0.86
Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds. Sci Rep (2014) 0.86
The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions. J Cereb Blood Flow Metab (2008) 0.86
Transplantation of CD15-enriched murine neural stem cells increases total engraftment and shifts differentiation toward the oligodendrocyte lineage. Stem Cells Transl Med (2013) 0.86
Human umbilical cord blood-derived mesenchymal stem cell therapy promotes functional recovery of contused rat spinal cord through enhancement of endogenous cell proliferation and oligogenesis. J Biomed Biotechnol (2012) 0.85
MR-based imaging of neural stem cells. Neuroradiology (2007) 0.85
Insights into neurogenesis and aging: potential therapy for degenerative disease? Future Neurol (2010) 0.84
Stem cell grafting improves both motor and cognitive impairments in a genetic model of Parkinson's disease, the aphakia (ak) mouse. Cell Transplant (2012) 0.84
ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models. Stem Cell Reports (2015) 0.83
Stem cell therapy in stroke: a review literature. Int J Prev Med (2013) 0.83
Longitudinal monitoring of stem cell grafts in vivo using magnetic resonance imaging with inducible maga as a genetic reporter. Theranostics (2014) 0.83
Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects. Am J Transl Res (2010) 0.83
Feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies. Int J Hematol Oncol Stem Cell Res (2013) 0.83
Methods to assess stem cell lineage, fate and function. Adv Drug Deliv Rev (2010) 0.83
Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease. J Cell Mol Med (2014) 0.83
Expression of alpha5 integrin rescues fibronectin responsiveness in NT2N CNS neuronal cells. J Neurosci Res (2010) 0.82
The human gastrointestinal tract, a potential autologous neural stem cell source. PLoS One (2013) 0.82
Synthetic Extracellular Microenvironment for Modulating Stem Cell Behaviors. Biomark Insights (2015) 0.82
Axon responses of embryonic stem cell-derived dopaminergic neurons to semaphorins 3A and 3C. J Neurosci Res (2010) 0.82
Cell based therapy for the management of chronic pain. Korean J Anesthesiol (2011) 0.82
Intracerebral adult stem cells transplantation increases brain-derived neurotrophic factor levels and protects against phencyclidine-induced social deficit in mice. Transl Psychiatry (2011) 0.81
Thermoresponsive hydrogel as a delivery scaffold for transfected rat mesenchymal stem cells. Mol Pharm (2010) 0.81
Neuroprotective effect of oligodendrocyte precursor cell transplantation in a long-term model of periventricular leukomalacia. Am J Pathol (2009) 0.81
Recovery of CNS pathway innervating the sciatic nerve following transplantation of human neural stem cells in rat spinal cord injury. Cell Mol Neurobiol (2011) 0.81
Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease. Stem Cells Transl Med (2016) 0.81
Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil. Mol Brain (2011) 0.80
Transplantation of adult neural progenitor cells transfected with vascular endothelial growth factor rescues grafted cells in the rat brain. Int J Biol Sci (2007) 0.80
Bioengineered Lacrimal Gland Organ Regeneration in Vivo. J Funct Biomater (2015) 0.80
Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects. Chem Cent J (2015) 0.79
Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice. PLoS Curr (2010) 0.79
Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges. Int J Mol Sci (2015) 0.79
Survival of neural progenitors allografted into the CNS of immunocompetent recipients is highly dependent on transplantation site. Cell Transplant (2013) 0.79
Magnetic resonance imaging using heparin-coated superparamagnetic iron oxide nanoparticles for cell tracking in vivo. Quant Imaging Med Surg (2012) 0.79
The role of stem cell therapy in multiple sclerosis: An overview of the current status of the clinical studies. Adv Biomed Res (2016) 0.78
Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med (2002) 10.10
Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci U S A (2003) 5.09
Stem cells in human neurodegenerative disorders--time for clinical translation? J Clin Invest (2010) 3.62
Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med (2004) 2.98
Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells (2005) 2.88
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci (2009) 2.74
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron (2006) 2.38
Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke (2007) 1.98
Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci (2006) 1.91
Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia (2009) 1.86
Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci (2009) 1.51
The endocannabinoid system drives neural progenitor proliferation. FASEB J (2005) 1.51
The response of the aged brain to stroke: too much, too soon? Curr Neurovasc Res (2007) 1.39
Stroke-induced neurogenesis in aged brain. Stroke (2005) 1.38
Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J Neurosci (2009) 1.37
Stem cell research in stroke: how far from the clinic? Stroke (2011) 1.37
Inflammation regulates functional integration of neurons born in adult brain. J Neurosci (2008) 1.35
Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells (2012) 1.34
The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells. J Neurosci (2006) 1.33
MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain. Mol Cell Neurosci (2008) 1.29
Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J Cereb Blood Flow Metab (2010) 1.24
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling. Lancet Neurol (2009) 1.23
Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatum. Eur J Neurosci (2007) 1.19
Perturbed cellular response to brain injury during aging. Ageing Res Rev (2009) 1.19
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats. Stroke (2006) 1.18
Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro. J Neurosci Res (2005) 1.15
Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone. Glia (2009) 1.11
Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats. J Neurosci Res (2006) 1.10
Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain (2013) 1.09
Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1. J Cereb Blood Flow Metab (2008) 1.05
TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain. Exp Neurol (2005) 1.03
Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats. Neurobiol Dis (2012) 1.02
Recovery and rehabilitation in stroke: stem cells. Stroke (2004) 1.01
Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons. Stem Cells (2012) 0.94
Quantitative analysis of the generation of different striatal neuronal subtypes in the adult brain following excitotoxic injury. Exp Neurol (2005) 0.93
Isolation and generation of neurosphere cultures from embryonic and adult mouse brain. Methods Mol Biol (2010) 0.93
Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain. Eur J Neurosci (2011) 0.92
Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment. Exp Neurol (2011) 0.90
Phenotypic and molecular identity of cells in the adult subventricular zone. in vivo and after expansion in vitro. Mol Cell Neurosci (2003) 0.90
Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis. J Cereb Blood Flow Metab (2011) 0.89
Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus. Stroke (2003) 0.89
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats. Neurobiol Dis (2003) 0.88
Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus. Exp Neurol (2003) 0.86
Stem cell therapy for human brain disorders. Kidney Int (2005) 0.86
Pax6 promotes neurogenesis in human neural stem cells. Mol Cell Neurosci (2008) 0.85
Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor. Exp Neurol (2002) 0.84
Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats. Neurobiol Dis (2002) 0.83
Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Eur J Neurosci (2003) 0.80
Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons. Neurobiol Dis (2006) 0.79
Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Exp Neurol (2011) 0.78
Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex. Neurobiol Dis (2003) 0.78
FoxJ1-expressing cells contribute to neurogenesis in forebrain of adult rats: evidence from in vivo electroporation combined with piggyBac transposon. Exp Cell Res (2013) 0.78
Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke. J Neurosci (2012) 0.78
The neuronal ceroid lipofuscinosis Cln8 gene expression is developmentally regulated in mouse brain and up-regulated in the hippocampal kindling model of epilepsy. BMC Neurosci (2005) 0.76
Societal value of stem cell therapy in stroke--a modeling study. Cerebrovasc Dis (2012) 0.75
Generation of cortical neurons from human induced-pluripotent stem cells by biodegradable polymeric microspheres loaded with priming factors. Biomed Mater (2016) 0.75