Published in Annu Rev Cell Dev Biol on January 01, 2006
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
ROS function in redox signaling and oxidative stress. Curr Biol (2014) 3.35
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2011) 3.28
A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One (2010) 3.14
Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol (2010) 2.85
BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J Exp Med (2007) 2.70
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Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol (2008) 2.32
Toll-like receptors as targets in chronic liver diseases. Gut (2009) 2.29
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol (2015) 2.21
Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells (2007) 2.08
Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation. J Clin Invest (2010) 1.88
Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages. Am J Physiol Lung Cell Mol Physiol (2007) 1.82
Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PLoS One (2008) 1.76
A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood (2007) 1.76
TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol (2008) 1.73
Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol (2007) 1.71
The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics (2007) 1.63
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway. Nat Commun (2012) 1.62
Effects of air pollutants on innate immunity: the role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Allergy Clin Immunol (2012) 1.55
Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. PLoS One (2015) 1.42
Danger signals activating the immune response after trauma. Mediators Inflamm (2012) 1.40
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity (2012) 1.40
Novel genes dramatically alter regulatory network topology in amphioxus. Genome Biol (2008) 1.32
The Role of TLR2 in Infection and Immunity. Front Immunol (2012) 1.28
Gene expression induced by Toll-like receptors in macrophages requires the transcription factor NFAT5. J Exp Med (2012) 1.28
TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen. J Immunol (2011) 1.27
New concepts on the immune modulation mediated by mesenchymal stem cells. Stem Cell Res Ther (2010) 1.24
Innate immunity and coagulation. J Thromb Haemost (2011) 1.24
Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses. Crit Rev Immunol (2010) 1.22
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Pathophysiology of cisplatin-induced acute kidney injury. Biomed Res Int (2014) 1.18
TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity. Eur J Immunol (2010) 1.16
The immunomodulatory properties of mesenchymal stem cells. Semin Immunopathol (2011) 1.16
MicroRNAs activate natural killer cells through Toll-like receptor signaling. Blood (2013) 1.15
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J Immunol (2009) 1.15
Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB. Proc Natl Acad Sci U S A (2010) 1.14
Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses. PLoS Pathog (2009) 1.12
Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytes. Infect Immun (2007) 1.10
Astrocyte elevated gene-1 (AEG-1) is induced by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and regulates TLR4 signalling. Immunology (2009) 1.09
Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling. PLoS One (2011) 1.09
Microbe-host interactions: structure and role of Gram-negative bacterial porins. Curr Protein Pept Sci (2012) 1.08
AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals. Cell Death Dis (2012) 1.05
The shape and dynamics of the Leptospiraceae. Biophys J (2007) 1.05
Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis. PLoS One (2011) 1.02
Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism. Am J Pathol (2008) 1.02
TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog. Dev Comp Immunol (2010) 1.01
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition. Mol Immunol (2009) 0.99
The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties. Glycoconj J (2013) 0.99
B cell TLRs and induction of immunoglobulin class-switch DNA recombination. Front Biosci (Landmark Ed) (2012) 0.99
Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice. J Virol (2008) 0.99
Domain architecture evolution of pattern-recognition receptors. Immunogenetics (2010) 0.99
Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. J Mol Biol (2010) 0.98
Molecular evolution of the vertebrate TLR1 gene family--a complex history of gene duplication, gene conversion, positive selection and co-evolution. BMC Evol Biol (2011) 0.98
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation. J Immunol (2014) 0.97
Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury. Shock (2014) 0.96
Mycoplasma genitalium-derived lipid-associated membrane proteins activate NF-kappaB through toll-like receptors 1, 2, and 6 and CD14 in a MyD88-dependent pathway. Clin Vaccine Immunol (2009) 0.95
Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J (2011) 0.94
Diversity and evolution of 11 innate immune genes in Bos taurus taurus and Bos taurus indicus cattle. Proc Natl Acad Sci U S A (2009) 0.93
Striking a balance: modulation of host cell death pathways by legionella pneumophila. Front Microbiol (2011) 0.93
S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol (2013) 0.92
RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol (2013) 0.92
Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Pediatr Nephrol (2010) 0.92
Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. PLoS One (2008) 0.91
Toll-Like Receptors (TLRs): The Role in Tumor Progression. Acta Naturae (2010) 0.91
Unifying themes in microbial associations with animal and plant hosts described using the gene ontology. Microbiol Mol Biol Rev (2010) 0.91
The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks. BMC Bioinformatics (2008) 0.90
Blowing on embers: commensal microbiota and our immune system. Front Immunol (2014) 0.90
Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des (2008) 0.90
Burn-induced alterations in toll-like receptor-mediated responses by bronchoalveolar lavage cells. Cytokine (2011) 0.89
Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet (2013) 0.88
MyD88 in DNA repair and cancer cell resistance to genotoxic drugs. J Natl Cancer Inst (2013) 0.87
In situ tissue regeneration: chemoattractants for endogenous stem cell recruitment. Tissue Eng Part B Rev (2013) 0.87
Burn enhances toll-like receptor induced responses by circulating leukocytes. Int J Clin Exp Med (2012) 0.86
Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome. PLoS One (2015) 0.86
Identification and function of myeloid differentiation factor 88 (MyD88) in Litopenaeus vannamei. PLoS One (2012) 0.86
A leucine-rich repeat assembly approach for homology modeling of the human TLR5-10 and mouse TLR11-13 ectodomains. J Mol Model (2010) 0.85
Evolutionary dynamism of the primate LRRC37 gene family. Genome Res (2012) 0.85
Aspects of innate immunity and Parkinson's disease. Front Pharmacol (2012) 0.85
Stage-specific innate immune recognition of Aspergillus fumigatus and modulation by echinocandin drugs. Med Mycol (2008) 0.85
Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C. ACS Chem Biol (2010) 0.85
Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator. J Virol (2014) 0.85
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J Clin Invest (2015) 0.85
MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis. Infect Immun (2009) 0.84
Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression. Hypertension (2015) 0.84
Nuclear factor kappaB (NF-kappaB) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist. Biochem J (2009) 0.84
Interferon induction by RNA viruses and antagonism by viral pathogens. Viruses (2014) 0.84
LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4. Dig Dis Sci (2014) 0.84
Tickling the TLR7 to cure viral hepatitis. J Transl Med (2014) 0.83
Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol (2013) 0.83
Mycoplasma lipoproteins and Toll-like receptors. J Zhejiang Univ Sci B (2009) 0.83
Dendritic cells during Staphylococcus aureus infection: subsets and roles. J Transl Med (2014) 0.83
Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation. FEBS Lett (2008) 0.83
Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection. PLoS One (2011) 0.83
Proposed mechanisms of action for prostate cancer vaccines. Nat Rev Urol (2013) 0.82
Characterization and structure of the vaccinia virus NF-κB antagonist A46. J Biol Chem (2013) 0.82
ArtinM offers new perspectives in the development of antifungal therapy. Front Microbiol (2012) 0.82
Shared principles in NF-kappaB signaling. Cell (2008) 20.96
Signaling to NF-kappaB. Genes Dev (2004) 19.78
Crosstalk in NF-κB signaling pathways. Nat Immunol (2011) 6.05
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell (2002) 5.84
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 5.26
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol (2009) 4.61
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
NF-κB, inflammation, and metabolic disease. Cell Metab (2011) 4.00
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science (2005) 3.74
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
Antigen-receptor signaling to nuclear factor kappa B. Immunity (2006) 3.07
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest (2007) 2.99
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med (2004) 2.94
A mouse model of Salmonella typhi infection. Cell (2012) 2.83
Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem (2001) 2.78
The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity (2003) 2.67
NF-κB in immunobiology. Cell Res (2011) 2.61
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2007) 2.43
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity (2009) 2.35
NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A (2004) 2.33
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity (2010) 2.02
Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J Immunol (2004) 1.84
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature (2010) 1.68
Characterization of the Ikappa B-kinase NEMO binding domain. J Biol Chem (2002) 1.65
Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms. Genes Dev (2008) 1.64
RelB forms transcriptionally inactive complexes with RelA/p65. J Biol Chem (2003) 1.63
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells. Nat Immunol (2009) 1.55
NF-κB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev (2013) 1.45
Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation. Blood (2007) 1.42
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity (2012) 1.40
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe (2013) 1.35
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem (2003) 1.35
Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. J Immunol (2007) 1.35
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem (2009) 1.30
Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum (2005) 1.27
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J Cell Biol (2006) 1.25
Role of nuclear factor-kappaB in the immune system and bone. Immunol Rev (2005) 1.21
Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev (2010) 1.21
Regulating inducible transcription through controlled localization. Sci STKE (2005) 1.20
Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. J Biol Chem (2007) 1.19
Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK. J Cell Sci (2004) 1.16
Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies. Mol Interv (2002) 1.16
A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem (2004) 1.16
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J (2008) 1.15
Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL. J Immunol (2009) 1.15
Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells. J Biol Chem (2003) 1.14
NF-kappaB, an evolutionarily conserved mediator of immune and inflammatory responses. Adv Exp Med Biol (2005) 1.10
Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities. Immunity (2002) 1.10
Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity. Mol Cell Biol (2006) 1.10
SnapShot: NF-kappaB signaling pathways. Cell (2006) 1.06
Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity (2008) 1.04
Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation. Arthritis Res Ther (2006) 1.04
Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. Immunology (2006) 1.00
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol (2007) 1.00
Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. J Mol Biol (2010) 0.98
Testing NF-κB-based therapy in hemiparkinsonian monkeys. J Neuroimmune Pharmacol (2012) 0.98
Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases. J Biol Chem (2003) 0.97
NFkappaB activates in vivo the synthesis of inducible Cox-2 in the brain. J Cereb Blood Flow Metab (2005) 0.96
The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem (2003) 0.94
Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol (2005) 0.92
The Two Faces of NF-κB Signaling in Cancer Development and Therapy. Cancer Cell (2011) 0.88
Elevated levels of select gangliosides in T cells from renal cell carcinoma patients is associated with T cell dysfunction. J Immunol (2009) 0.87
Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice. PLoS One (2011) 0.87
CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation. Eur J Immunol (2002) 0.87
Regulation of IkappaBbeta expression in testis. Mol Biol Cell (2002) 0.87
NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha. Int Immunol (2006) 0.86
The kinase PDK1 is essential for B-cell receptor mediated survival signaling. PLoS One (2013) 0.85
Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur J Immunol (2005) 0.84
'PPAR'ting ways with inflammation. Nat Immunol (2005) 0.84
Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem (2014) 0.82
A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. PLoS One (2013) 0.81
Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A (2014) 0.81
Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation. J Immunol (2013) 0.80
TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. J Immunol (2007) 0.80
Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches. J Biol Chem (2012) 0.80
Direct activation of protein kinases by ubiquitin. J Mol Cell Biol (2009) 0.75
Keeping cartographers busy. Nat Cell Biol (2004) 0.75