NF-κB, inflammation, and metabolic disease.

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Published in Cell Metab on January 05, 2011

Authors

Rebecca G Baker1, Matthew S Hayden, Sankar Ghosh

Author Affiliations

1: Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/p65 heterodimers and p65 homodimers while enhancing the binding of p50 homodimers. J Biol Chem (2003) 0.94

Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol (2005) 0.92

The Two Faces of NF-κB Signaling in Cancer Development and Therapy. Cancer Cell (2011) 0.88

Regulation of IkappaBbeta expression in testis. Mol Biol Cell (2002) 0.87

CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation. Eur J Immunol (2002) 0.87

Elevated levels of select gangliosides in T cells from renal cell carcinoma patients is associated with T cell dysfunction. J Immunol (2009) 0.87

Cell-intrinsic NF-κB activation is critical for the development of natural regulatory T cells in mice. PLoS One (2011) 0.87

NF-kappaB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFalpha. Int Immunol (2006) 0.86

The kinase PDK1 is essential for B-cell receptor mediated survival signaling. PLoS One (2013) 0.85

Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur J Immunol (2005) 0.84

'PPAR'ting ways with inflammation. Nat Immunol (2005) 0.84

Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem (2014) 0.82

Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A (2014) 0.81

A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. PLoS One (2013) 0.81

Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation. J Immunol (2013) 0.80

TNF-alpha induction of GM2 expression on renal cell carcinomas promotes T cell dysfunction. J Immunol (2007) 0.80

Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches. J Biol Chem (2012) 0.80

A less-canonical, canonical NF-κB pathway in DCs. Nat Immunol (2012) 0.79