Published in Semin Cancer Biol on May 10, 2006
High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci U S A (2008) 1.59
MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. Proc Natl Acad Sci U S A (2010) 1.49
MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells. Biochem Biophys Res Commun (2006) 1.42
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc Natl Acad Sci U S A (2013) 1.33
MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. Cell Death Differ (2011) 1.24
Functional sphere profiling reveals the complexity of neuroblastoma tumor-initiating cell model. Neoplasia (2011) 1.15
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients. Mol Cancer (2010) 1.10
Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models. PLoS One (2012) 0.98
Targeting of the MYCN protein with small molecule c-MYC inhibitors. PLoS One (2014) 0.97
Targeting MYC-Regulated miRNAs to Combat Cancer. Genes Cancer (2010) 0.94
Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma. BMC Dev Biol (2011) 0.94
Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci U S A (2012) 0.93
Logic Learning Machine creates explicit and stable rules stratifying neuroblastoma patients. BMC Bioinformatics (2013) 0.89
LMNA knock-down affects differentiation and progression of human neuroblastoma cells. PLoS One (2012) 0.86
MicroRNA and DNA methylation alterations mediating retinoic acid induced neuroblastoma cell differentiation. Semin Cancer Biol (2011) 0.84
Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. Proc Natl Acad Sci U S A (2014) 0.83
Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. ScientificWorldJournal (2013) 0.82
The role of Connexin 46 promoter in lens and other hypoxic tissues. Commun Integr Biol (2012) 0.82
Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth. Cell Death Dis (2012) 0.80
A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastoma. PLoS One (2013) 0.80
Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. J Clin Invest (2013) 0.80
Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells. Sci Rep (2015) 0.79
Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. PLoS One (2010) 0.79
Neuritogenic and neuroprotective effects of polar steroids from the Far East starfishes Patiria pectinifera and Distolasterias nipon. Mar Drugs (2013) 0.78
Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. J Clin Invest (2014) 0.78
A nanoporous surface is essential for glomerular podocyte differentiation in three-dimensional culture. Int J Nanomedicine (2016) 0.75
Neoglucosylated collagen matrices drive neuronal cells to differentiate. ACS Chem Neurosci (2014) 0.75
Artificial neural network classifier predicts neuroblastoma patients' outcome. BMC Bioinformatics (2016) 0.75
Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells. Toxicol Res (2016) 0.75
Sub-micromolar concentrations of retinoic acid induce morphological and functional neuronal phenotypes in SK-N-SH neuroblastoma cells. In Vitro Cell Dev Biol Anim (2017) 0.75
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell (2006) 4.01
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A (2002) 2.39
Hypoxia inducible factor-2alpha in cancer. Cell Cycle (2007) 1.90
Hypoxia-induced dedifferentiation of tumor cells--a mechanism behind heterogeneity and aggressiveness of solid tumors. Semin Cell Dev Biol (2005) 1.66
High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci U S A (2008) 1.59
Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res (2008) 1.59
Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res (2003) 1.56
MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. Proc Natl Acad Sci U S A (2010) 1.49
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 1.46
Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biol (2006) 1.44
Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer. Mod Pathol (2009) 1.34
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc Natl Acad Sci U S A (2013) 1.33
Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem (2004) 1.31
Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior. Exp Cell Res (2004) 1.22
Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem (2001) 1.12
Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells. Biochem Biophys Res Commun (2008) 1.10
High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer. Proteomics Clin Appl (2011) 1.10
Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1. Genes Chromosomes Cancer (2006) 1.08
HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia. Exp Cell Res (2005) 1.03
JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation. Mol Cancer Res (2011) 1.02
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res (2009) 1.02
Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell (2002) 1.02
The HIF-2α-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization. Curr Top Microbiol Immunol (2010) 1.01
Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation. Lab Invest (2004) 0.96
Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res (2004) 0.95
Transcriptional adaptation of neuroblastoma cells to hypoxia. Biochem Biophys Res Commun (2007) 0.94
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells. Mol Cancer Ther (2009) 0.94
Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Lab Invest (2003) 0.93
Hypoxia-induced dedifferentiation in neuroblastoma cells. Cancer Lett (2003) 0.93
Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models. Adv Exp Med Biol (2006) 0.91
Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells. Int J Cancer (2005) 0.91
Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors. Ups J Med Sci (2012) 0.90
Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells. Mol Cancer Ther (2007) 0.89
Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism. J Proteome Res (2013) 0.88
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene (2003) 0.88
The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cell Signal (2013) 0.88
Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification. PLoS One (2008) 0.88
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate (2007) 0.87
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia (2013) 0.87
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11. BMC Genomics (2005) 0.87
Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS One (2012) 0.85
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. Cancer Res (2008) 0.85
HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells. Exp Cell Res (2009) 0.84
HIF-2α expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1α is repressed. Am J Pathol (2011) 0.83
Arsenic trioxide and neuroblastoma cytotoxicity. J Bioenerg Biomembr (2007) 0.83
The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma. Int J Cancer (2006) 0.81
Tumor-initiating cells in childhood neuroblastoma--letter. Cancer Res (2012) 0.81
Differentiation induced by physiological and pharmacological stimuli leads to increased antigenicity of human neuroblastoma cells. Cell Res (2008) 0.81
Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells. Int J Oncol (2004) 0.80
Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage. Semin Cancer Biol (2011) 0.79
Erythropoietin receptor expression and correlation to tamoxifen response and prognosis in breast cancer. Clin Cancer Res (2009) 0.79
Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours. Int J Cancer (2014) 0.79
Prognostic value of SOX2 expression in neuroblastoma. Genes Chromosomes Cancer (2011) 0.79
snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis. Transl Oncol (2013) 0.79
Erythropoietin therapy and cancer related anaemia: updated Swedish recommendations. Med Oncol (2007) 0.78
Multidrug-resistant neuroblastoma cells are responsive to arsenic trioxide at both normoxia and hypoxia. Mol Cancer Ther (2005) 0.78
Regional cyclin D1 overexpression or hypoxia correlate inversely with heterogeneous oestrogen receptor-alpha expression in human breast cancer. In Vivo (2003) 0.77
Hunting for protein markers of hypoxia by combining plasma membrane enrichment with a new approach to membrane protein analysis. J Proteome Res (2011) 0.76
Neuroblastoma research progress--a 2011 perspective. Semin Cancer Biol (2011) 0.75
Erythropoietin enhances response to treatment in patients with advanced breast cancer. Acta Oncol (2004) 0.75