Published in Biochem Biophys Res Commun on October 01, 2008
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol (2013) 2.34
The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol (2011) 2.07
Making sense of hematopoietic stem cell niches. Blood (2015) 1.23
Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia (2011) 0.92
Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils. PLoS One (2012) 0.92
Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue Eng Part A (2014) 0.92
Activation of diverse signaling pathways by ex-vivo delivery of multiple cytokines for myocardial repair. Stem Cells Dev (2012) 0.92
Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells. PLoS One (2011) 0.89
Angiogenic and vasculogenic factors in the vitreous from patients with proliferative diabetic retinopathy. J Diabetes Res (2013) 0.88
Regulation of cell proliferation by hypoxia-inducible factors. Am J Physiol Cell Physiol (2015) 0.83
Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci (2015) 0.80
Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury. Pediatr Res (2013) 0.80
The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells. J Biol Chem (2013) 0.80
Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79
Loss of HIF-1α accelerates murine FLT-3(ITD)-induced myeloproliferative neoplasia. Leukemia (2015) 0.78
Regulatory Interactions in the Bone Marrow Microenvironment. IBMS Bonekey (2015) 0.77
SCF, regulated by HIF-1α, promotes pancreatic ductal adenocarcinoma cell progression. PLoS One (2015) 0.77
Hypoxia and Hypoxia-Inducible Factors in Leukemias. Front Oncol (2016) 0.76
Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function. PLoS One (2017) 0.75
Radiolabeled probes targeting hypoxia-inducible factor-1-active tumor microenvironments. ScientificWorldJournal (2014) 0.75
Integration of hypoxic HIF-α signaling in blood cancers. Oncogene (2017) 0.75
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell (2006) 4.01
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell (2003) 3.58
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science (2003) 3.19
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A (2002) 2.39
Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev (2012) 2.13
Hypoxia inducible factor-2alpha in cancer. Cell Cycle (2007) 1.90
Hypoxia-induced dedifferentiation of tumor cells--a mechanism behind heterogeneity and aggressiveness of solid tumors. Semin Cell Dev Biol (2005) 1.66
High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc Natl Acad Sci U S A (2008) 1.59
Hypoxia-inducible factor-2alpha correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res (2008) 1.59
A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood (2009) 1.58
Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res (2003) 1.56
Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J Med Chem (2010) 1.55
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A (2011) 1.52
MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. Proc Natl Acad Sci U S A (2010) 1.49
The characterization of epithelial and stromal subsets of candidate stem/progenitor cells in the human adult prostate. Eur Urol (2007) 1.46
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 1.46
Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes. Genome Biol (2006) 1.44
p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med (2004) 1.42
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3. Cell Signal (2009) 1.40
Protein kinase C expression is deregulated in chronic lymphocytic leukemia. Leuk Lymphoma (2013) 1.40
Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer. Mod Pathol (2009) 1.34
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem (2004) 1.33
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells. Proc Natl Acad Sci U S A (2013) 1.33
Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation. Semin Cancer Biol (2006) 1.31
Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. J Biol Chem (2004) 1.31
The specificity of JAK3 kinase inhibitors. Blood (2007) 1.28
Human neuroblastoma cells exposed to hypoxia: induction of genes associated with growth, survival, and aggressive behavior. Exp Cell Res (2004) 1.22
Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation. Biochem J (2006) 1.12
Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem (2001) 1.12
High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer. Proteomics Clin Appl (2011) 1.10
Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J (2003) 1.10
Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res (2003) 1.09
Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1. Genes Chromosomes Cancer (2006) 1.08
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection. Plant Cell (2003) 1.06
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol (2002) 1.04
HIF-2alpha expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia. Exp Cell Res (2005) 1.03
JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation. Mol Cancer Res (2011) 1.02
Src family kinases are involved in the differential signaling from two splice forms of c-Kit. J Biol Chem (2003) 1.02
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res (2009) 1.02
Protein kinase Cepsilon actin-binding site is important for neurite outgrowth during neuronal differentiation. Mol Biol Cell (2002) 1.02
The HIF-2α-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization. Curr Top Microbiol Immunol (2010) 1.01
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood (2012) 1.00
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem (2008) 0.99
Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. Exp Hematol (2009) 0.98
A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell (2013) 0.98
Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem (2010) 0.98
Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res (2007) 0.97
Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation. Lab Invest (2004) 0.96
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene (2002) 0.96
SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML. Blood (2012) 0.95
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem (2011) 0.95
Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin Cancer Res (2004) 0.95
Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. J Biol Chem (2012) 0.94
Transcriptional adaptation of neuroblastoma cells to hypoxia. Biochem Biophys Res Commun (2007) 0.94
Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells. Mol Cancer Ther (2009) 0.94
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation. Blood (2011) 0.94
miR-454 is down-regulated in osteosarcomas and suppresses cell proliferation and invasion by directly targeting c-Met. Cell Prolif (2015) 0.94
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem (2004) 0.94
Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K/AKT and MAPK pathways. PLoS One (2013) 0.93
Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. Lab Invest (2003) 0.93
SOCS proteins in regulation of receptor tyrosine kinase signaling. Cell Mol Life Sci (2014) 0.93
Hypoxia-induced dedifferentiation in neuroblastoma cells. Cancer Lett (2003) 0.93
MicroRNA-23a modulates tumor necrosis factor-alpha-induced osteoblasts apoptosis by directly targeting Fas. J Cell Biochem (2013) 0.92
Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models. Adv Exp Med Biol (2006) 0.91
Phenotypic persistence after reoxygenation of hypoxic neuroblastoma cells. Int J Cancer (2005) 0.91
Cancer cell differentiation heterogeneity and aggressive behavior in solid tumors. Ups J Med Sci (2012) 0.90
A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Br J Haematol (2009) 0.90
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Mol Oncol (2012) 0.90
Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem Biophys Res Commun (2011) 0.89
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. Biochim Biophys Acta (2003) 0.89
Identification of protein tyrosine phosphatases associating with the PDGF receptor. Biochemistry (2003) 0.89
Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells. Mol Cancer Ther (2007) 0.89
Quantitative proteomics profiling of primary lung adenocarcinoma tumors reveals functional perturbations in tumor metabolism. J Proteome Res (2013) 0.88
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene (2003) 0.88
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit. Biochem J (2003) 0.88
The tyrosine kinase CSK associates with FLT3 and c-Kit receptors and regulates downstream signaling. Cell Signal (2013) 0.88
SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. Tumour Biol (2014) 0.88
Ezrin is a substrate for Lck in T cells. FEBS Lett (2003) 0.88
Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification. PLoS One (2008) 0.88
The presence or absence of IL-3 during long-term culture of Flt3-ITD and c-Kit-D816V expressing Ba/F3 cells influences signaling outcome. Exp Hematol (2013) 0.88
C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One (2011) 0.88
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11. BMC Genomics (2005) 0.87
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate (2007) 0.87
Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling. Mol Oncol (2013) 0.87