Published in Cereb Cortex on July 11, 2006
Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci (2008) 6.97
Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci U S A (2011) 2.85
Adolescent brain development and the risk for alcohol and other drug problems. Neuropsychol Rev (2010) 1.71
Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. J Neurosci (2014) 1.53
A neonatal ventral hippocampal lesion causes functional deficits in adult prefrontal cortical interneurons. J Neurosci (2008) 1.51
Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment. Brain Cogn (2009) 1.44
Genes, cognition and brain through a COMT lens. Neuroscience (2009) 1.43
Ten good reasons to consider biological processes in prevention and intervention research. Dev Psychopathol (2008) 1.41
Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neurosci Biobehav Rev (2009) 1.41
Neural correlates of reward processing in adults with 22q11 deletion syndrome. J Neurodev Disord (2016) 1.40
Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia. BMC Med Genomics (2009) 1.31
Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology (2009) 1.27
Anatomic magnetic resonance imaging of the developing child and adolescent brain and effects of genetic variation. Neuropsychol Rev (2010) 1.19
Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. Biol Psychiatry (2011) 1.18
Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development. Neuroscience (2009) 1.16
COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biol Psychiatry (2012) 1.16
Is COMT a susceptibility gene for schizophrenia? Schizophr Bull (2007) 1.14
Relationship of striatal dopamine synthesis capacity to age and cognition. J Neurosci (2008) 1.05
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry (2009) 1.05
Age modulates the effect of COMT genotype on delay discounting behavior. Psychopharmacology (Berl) (2012) 1.02
Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neurosci Biobehav Rev (2011) 1.00
Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology (2013) 0.98
Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J Biol Chem (2011) 0.97
Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain. Psychopharmacology (Berl) (2014) 0.96
Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome. Biol Psychiatry (2013) 0.95
Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome. Cogn Affect Behav Neurosci (2009) 0.94
Sex modulates the associations between the COMT gene and personality traits. Neuropsychopharmacology (2011) 0.92
Developmental changes in human dopamine neurotransmission: cortical receptors and terminators. BMC Neurosci (2012) 0.90
Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Dev Psychol (2010) 0.89
Effects of the Val158Met catechol-O-methyltransferase polymorphism on cortical structure in children and adolescents. Mol Psychiatry (2009) 0.87
A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes Brain Behav (2010) 0.87
The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. J Neurol Neurosurg Psychiatry (2013) 0.86
Sex differences in COMT polymorphism effects on prefrontal inhibitory control in adolescence. Neuropsychopharmacology (2014) 0.81
COMT Val108/158Met polymorphism and the modulation of task-oriented behavior in children with ADHD. Neuropsychopharmacology (2008) 0.80
Reduced cerebellar brain activity during reward processing in adolescent binge drinkers. Dev Cogn Neurosci (2015) 0.80
Developmental changes of prefrontal activation in humans: a near-infrared spectroscopy study of preschool children and adults. PLoS One (2011) 0.79
Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR. Am J Med Genet B Neuropsychiatr Genet (2010) 0.79
Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets. J Neural Transm (Vienna) (2009) 0.78
Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility. Dev Psychopathol (2014) 0.78
Neurobiology of adolescent substance use and addictive behaviors: treatment implications. Adolesc Med State Art Rev (2014) 0.76
Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator. BMC Med Genomics (2014) 0.76
Age moderates the effect of acute dopamine depletion on passive avoidance learning. Pharmacol Biochem Behav (2015) 0.76
Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. J Cogn Neurosci (2013) 0.75
COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Genes Brain Behav (2016) 0.75
A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. Medicine (Baltimore) (2017) 0.75
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A (1996) 12.89
Socioeconomic factors, health behaviors, and mortality: results from a nationally representative prospective study of US adults. JAMA (1998) 11.90
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell (1995) 11.72
Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A (2001) 9.42
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry (2005) 9.23
Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol (2003) 9.10
Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry (1987) 8.81
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell (1997) 8.28
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A (1997) 7.52
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35
Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity (1995) 6.91
Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science (2001) 6.47
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A (1980) 6.31
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell (1997) 5.92
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev (1994) 5.68
Genetic diversity and disease control in rice. Nature (2000) 5.34
An essential role for Rac in Ras transformation. Nature (1995) 5.34
Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol (2009) 5.08
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell (1999) 4.76
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med (2000) 4.54
Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology (2002) 4.45
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res (2001) 4.38
Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry (1986) 4.34
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest (1997) 4.31
Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature (1999) 4.29
Demethylation-induced developmental pleiotropy in Arabidopsis. Science (1996) 4.25
Overland heroin trafficking routes and HIV-1 spread in south and south-east Asia. AIDS (2000) 4.24
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys (1992) 4.12
Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. Biol Chem Hoppe Seyler (1994) 4.09
A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06
Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis. Diabet Med (2011) 4.04
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
Identification of a nuclear receptor that is activated by farnesol metabolites. Cell (1995) 3.92
B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med (2000) 3.89
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J (2005) 3.84
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell (1999) 3.83
Two regulatory genes of the maize anthocyanin pathway are homologous: isolation of B utilizing R genomic sequences. Plant Cell (1989) 3.83
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy (2007) 3.75
Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control (2001) 3.74
Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell (1995) 3.70
Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene (2009) 3.64
A role for Rho in Ras transformation. Proc Natl Acad Sci U S A (1995) 3.59
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56
Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature (1999) 3.51
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature (1995) 3.39
Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex (2000) 3.37
Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2. Proc Natl Acad Sci U S A (1998) 3.34
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J Exp Med (1998) 3.32
Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex (1999) 3.31
Closing the gap between research and practice. Br J Psychiatry (1997) 3.26
Pulsed-field fingerprinting of listeriae: identification of genomic divisions for Listeria monocytogenes and their correlation with serovar. Appl Environ Microbiol (1994) 3.24
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature (1998) 3.23
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N Engl J Med (1990) 3.10
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09
Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol (2000) 3.08
Neuropsychological assessment of monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry (1990) 3.07
Oxidative chemistry of peroxynitrite. Methods Enzymol (1994) 3.03
Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia (2003) 3.00
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc Natl Acad Sci U S A (1997) 3.00
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res (1994) 2.98
Stable microreentrant sources as a mechanism of atrial fibrillation in the isolated sheep heart. Circulation (2000) 2.97
Rates of dementia in three ethnoracial groups. Int J Geriatr Psychiatry (1999) 2.92
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A (1999) 2.83
Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet (1998) 2.81
Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am J Psychiatry (2001) 2.80
VDJ recombination. Immunol Today (1992) 2.74
Bcl-2 family proteins are essential for platelet survival. Cell Death Differ (2007) 2.67
Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J Virol (1995) 2.66
Clinical and genetic studies of Birt-Hogg-Dubé syndrome. J Med Genet (2002) 2.65
Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature (1997) 2.64
The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter. Plant Cell (2001) 2.63
Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry (2000) 2.62
Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med (2000) 2.61
The effect of hiatus hernia on gastro-oesophageal junction pressure. Gut (1999) 2.60
Noise reduction in 3D perfusion imaging by attenuating the static signal in arterial spin tagging (ASSIST). Magn Reson Med (2000) 2.58
Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev (1996) 2.58
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol (1998) 2.54
Neurophysiological correlates of age-related changes in human motor function. Neurology (2002) 2.52
Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J Immunol (1998) 2.52
Characterization of a Na+/H+ antiporter gene of Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.51
Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport (2000) 2.49
Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry (1997) 2.48
Role of guanylate cyclase-activating proteins (GCAPs) in setting the flash sensitivity of rod photoreceptors. Proc Natl Acad Sci U S A (2001) 2.44
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia. Mol Psychiatry (2002) 2.43
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene (2011) 2.42
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. Proc Natl Acad Sci U S A (1999) 2.41
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med (2001) 2.40