Published in Pharmacol Ther on July 11, 2006
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Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem Pharmacol (2008) 1.14
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Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A (2006) 1.12
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Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J (2002) 1.07
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The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. Immunology (2008) 1.02
Celecoxib inhibits 5-lipoxygenase. Biochem Pharmacol (2008) 0.99
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PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells. Carcinogenesis (2008) 0.97
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Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. Biochem Biophys Res Commun (2002) 0.93
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Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim Biophys Acta (2006) 0.87
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Trichostatin A and structurally related histone deacetylase inhibitors induce 5-lipoxygenase promoter activity. Biol Chem (2003) 0.86
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem (2008) 0.86
The TGFbeta/Smad 3-signaling pathway is involved in butyrate-mediated vitamin D receptor (VDR)-expression. J Cell Biochem (2007) 0.86
Calcitriol upregulates open chromatin and elongation markers at functional vitamin D response elements in the distal part of the 5-lipoxygenase gene. J Mol Biol (2009) 0.85
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The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Mol Pharmacol (2005) 0.85
The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4. Biochem Biophys Res Commun (2006) 0.85
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells. Proc Natl Acad Sci U S A (2005) 0.85
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Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem (2007) 0.84
Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors. J Med Chem (2005) 0.84
Peroxisome proliferator-activated receptor alpha (PPAR alpha) down-regulation in cystic fibrosis lymphocytes. Respir Res (2006) 0.83
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cell Mol Life Sci (2009) 0.83
From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties. ChemMedChem (2013) 0.82
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Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. J Cell Mol Med (2012) 0.82
DNA methylation regulates 5-lipoxygenase promoter activity. Adv Exp Med Biol (2003) 0.82
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cell Mol Life Sci (2009) 0.82
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity. Biochim Biophys Acta (2009) 0.82
Transient transfection of the human myeloid cell line Mono Mac 6 using electroporation. Biotechniques (2003) 0.82
Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing. J Proteome Res (2009) 0.82
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Scaffold-hopping cascade yields potent inhibitors of 5-lipoxygenase. ChemMedChem (2008) 0.81
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1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain. J Biol Chem (2005) 0.81
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416. Biochim Biophys Acta (2011) 0.80
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. J Med Chem (2011) 0.80
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Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. J Med Chem (2014) 0.80
Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro. PLoS One (2012) 0.79
Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development. Expert Opin Drug Discov (2013) 0.79
Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions. Biochim Biophys Acta (2009) 0.79
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Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro. Biochem Biophys Res Commun (2007) 0.79
The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes. J Leukoc Biol (2008) 0.79
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Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV. Biochem Biophys Res Commun (2011) 0.79
ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. Biochem Biophys Res Commun (2002) 0.78
Overexpression, refolding, and purification of polyhistidine-tagged human retinoic acid related orphan receptor RORalpha4. Protein Expr Purif (2006) 0.78
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors. Bioorg Med Chem (2012) 0.78
Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription. Future Med Chem (2010) 0.78
Characterisation of taxlllaids A-G; natural products from Xenorhabdus indica. Chemistry (2014) 0.78
Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem (2006) 0.78
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. Biochim Biophys Acta (2005) 0.78
Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. Cancer Chemother Pharmacol (2010) 0.78
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Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase. J Med Chem (2006) 0.78
Complementary screening techniques yielded fragments that inhibit the phosphatase activity of soluble epoxide hydrolase. ChemMedChem (2011) 0.78
Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation. Antioxid Redox Signal (2014) 0.77
Resveratrol-induced potentiation of the antitumor effects of oxaliplatin is accompanied by an altered cytokine profile of human monocyte-derived macrophages. Apoptosis (2014) 0.77
MicroRNAs-novel therapeutic targets of eicosanoid signalling. Basic Clin Pharmacol Toxicol (2013) 0.77
5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells. Cell Signal (2013) 0.77
Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol (2011) 0.77
Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS. FEBS J (2014) 0.77
The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. J Biol Chem (2003) 0.77
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes. PLoS One (2013) 0.77
Development of a method for expression and purification of the regulatory C2-like domain of human 5-lipoxygenase. Protein Expr Purif (2008) 0.77
Mass spectrometry-based proteomics identifies UPF1 as a critical gene expression regulator in MonoMac 6 cells. J Proteome Res (2013) 0.77
5-Lipoxygenase activation by MAPKAPK-2 and ERKs. Adv Exp Med Biol (2003) 0.77
Potent inhibitors of 5-lipoxygenase identified using pseudoreceptors. ChemMedChem (2011) 0.77
Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes. J Leukoc Biol (2002) 0.77
Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes. Exp Dermatol (2008) 0.76
A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods (2002) 0.76