Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells.

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Published in Osteoporos Int on September 01, 2011

Authors

S K Baniwal1, P K Shah, Y Shi, J H Haduong, Y A Declerck, Y Gabet, B Frenkel

Author Affiliations

1: Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature (1996) 10.67

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci U S A (1990) 4.40

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mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A (1997) 3.01

Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature (1996) 2.94

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol (2004) 2.90

Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J (2001) 2.81

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Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone (1999) 2.69

The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proc Natl Acad Sci U S A (1999) 2.48

Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev (2004) 2.28

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Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem (2002) 2.14

B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J (1988) 2.11

Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell (2003) 2.11

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Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. Am J Physiol (1999) 1.27

Differentiation of B cell progenitors in vitro: generation of surface IgM+ B cells, including Ly-1 B cells, from Thy-1- asialoGM1+ cells in newborn liver. Eur J Immunol (1987) 1.26

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Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta-cells. J Biol Chem (2006) 1.21

Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro. J Bone Miner Res (1991) 1.21

Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Dev Biol (2005) 1.20

Eph receptors and ephrin signaling pathways: a role in bone homeostasis. Int J Med Sci (2008) 1.17

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Behavior of osteoblast, adipocyte, and myoblast markers in genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro. Bone (2002) 1.14

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