A form of motor cortical plasticity that correlates with recovery of function after brain injury.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMC 1544093)

Published in Proc Natl Acad Sci U S A on July 12, 2006

Authors

Dhakshin Ramanathan1, James M Conner, Mark H Tuszynski

Author Affiliations

1: Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0626, USA.

Articles citing this

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat Neurosci (2009) 2.37

Microstimulation activates a handful of muscle synergies. Neuron (2012) 2.07

The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. Cereb Cortex (2010) 1.96

Functional clustering of neurons in motor cortex determined by cellular resolution imaging in awake behaving mice. J Neurosci (2009) 1.86

Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats. Neurorehabil Neural Repair (2007) 1.48

Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions. Exp Neurol (2008) 1.40

Reorganization of motor cortex after controlled cortical impact in rats and implications for functional recovery. J Neurotrauma (2010) 1.32

Bone marrow stromal cells enhance inter- and intracortical axonal connections after ischemic stroke in adult rats. J Cereb Blood Flow Metab (2010) 1.24

Experience-dependent neural plasticity in the adult damaged brain. J Commun Disord (2011) 1.12

The aging mind: neuroplasticity in response to cognitive training. Dialogues Clin Neurosci (2013) 1.11

Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice. Proc Natl Acad Sci U S A (2009) 1.08

Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke. Stroke (2013) 1.04

Skill learning induced plasticity of motor cortical representations is time and age-dependent. Neurobiol Learn Mem (2012) 0.98

All rodents are not the same: a modern synthesis of cortical organization. Brain Behav Evol (2011) 0.95

Overlapping representations of the neck and whiskers in the rat motor cortex revealed by mapping at different anaesthetic depths. Eur J Neurosci (2007) 0.95

What single-cell stimulation has told us about neural coding. Philos Trans R Soc Lond B Biol Sci (2015) 0.92

Identification of a cellular node for motor control pathways. Nat Neurosci (2014) 0.91

Cortex commands the performance of skilled movement. Elife (2015) 0.90

Cortical reorganization after spinal cord injury: always for good? Neuroscience (2014) 0.89

Experience--a double edged sword for restorative neural plasticity after brain damage. Future Neurol (2008) 0.88

Vagus Nerve Stimulation Delivered with Motor Training Enhances Recovery of Function after Traumatic Brain Injury. J Neurotrauma (2015) 0.88

Post-stroke protection from maladaptive effects of learning with the non-paretic forelimb by bimanual home cage experience in C57BL/6 mice. Behav Brain Res (2013) 0.88

Sleep-Dependent Reactivation of Ensembles in Motor Cortex Promotes Skill Consolidation. PLoS Biol (2015) 0.87

Representation of Muscle Synergies in the Primate Brain. J Neurosci (2015) 0.87

Spatial organization of cortical and spinal neurons controlling motor behavior. Curr Opin Neurobiol (2012) 0.86

Age-dependent reorganization of peri-infarct "premotor" cortex with task-specific rehabilitative training in mice. Neurorehabil Neural Repair (2014) 0.86

The functional organization and cortical connections of motor cortex in squirrels. Cereb Cortex (2011) 0.83

Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection. Physiology (Bethesda) (2015) 0.83

Combinatorial Motor Training Results in Functional Reorganization of Remaining Motor Cortex after Controlled Cortical Impact in Rats. J Neurotrauma (2015) 0.82

Use it and/or lose it-experience effects on brain remodeling across time after stroke. Front Hum Neurosci (2014) 0.82

Transplantation of bone marrow stromal cells enhances nerve regeneration of the corticospinal tract and improves recovery of neurological functions in a collagenase-induced rat model of intracerebral hemorrhage. Mol Cells (2013) 0.81

Speed of motor re-learning after experimental stroke depends on prior skill. Exp Brain Res (2007) 0.80

Towards a circuit mechanism for movement tuning in motor cortex. Front Neural Circuits (2013) 0.80

Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm. Front Neurosci (2016) 0.79

Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury. Exp Neurol (2012) 0.79

Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice. Cell Death Dis (2013) 0.79

Adaptive changes in the motor cortex during and after longterm forelimb immobilization in adult rats. J Physiol (2014) 0.78

Neuromuscular Plasticity: Disentangling Stable and Variable Motor Maps in the Human Sensorimotor Cortex. Neural Plast (2016) 0.78

Motor cortex maturation is associated with reductions in recurrent connectivity among functional subpopulations and increases in intrinsic excitability. J Neurosci (2015) 0.78

Gene expression changes in the motor cortex mediating motor skill learning. PLoS One (2013) 0.78

Trunk robot rehabilitation training with active stepping reorganizes and enriches trunk motor cortex representations in spinal transected rats. J Neurosci (2015) 0.78

No learning where to go without first knowing where you're coming from: action discovery is trajectory, not endpoint based. Front Psychol (2013) 0.77

Evolution of posterior parietal cortex and parietal-frontal networks for specific actions in primates. J Comp Neurol (2015) 0.77

Pilot fMRI investigation of representational plasticity associated with motor skill learning and its functional consequences. Brain Imaging Behav (2012) 0.76

Early poststroke experience differentially alters periinfarct layer II and III cortex. J Cereb Blood Flow Metab (2014) 0.76

Neural plasticity after spinal cord injury. Neural Regen Res (2012) 0.76

Forelimb training drives transient map reorganization in ipsilateral motor cortex. Behav Brain Res (2016) 0.76

Reorganization of corticospinal output during motor learning. Nat Neurosci (2017) 0.75

Understanding the Mechanisms of Recovery and/or Compensation following Injury. Neural Plast (2017) 0.75

Sensorimotor restriction affects complex movement topography and reachable space in the rat motor cortex. Front Syst Neurosci (2014) 0.75

Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits. J Neurophysiol (2014) 0.75

Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation. Front Cell Neurosci (2017) 0.75

Motor cortex - to act or not to act? Nat Rev Neurosci (2017) 0.75

Organization of the reach and grasp in head-fixed vs freely-moving mice provides support for multiple motor channel theory of neocortical organization. Exp Brain Res (2017) 0.75

Articles cited by this

Neuronal population coding of movement direction. Science (1986) 8.79

Cortical map reorganization enabled by nucleus basalis activity. Science (1998) 5.65

Massive cortical reorganization after sensory deafferentation in adult macaques. Science (1991) 5.05

Complex movements evoked by microstimulation of precentral cortex. Neuron (2002) 4.46

Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J Neurosci (1996) 4.10

Plasticity and primary motor cortex. Annu Rev Neurosci (2000) 3.74

Muscle and movement representations in the primary motor cortex. Science (1999) 3.19

Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task. J Neurophysiol (1992) 3.16

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron (2003) 2.52

Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning. J Neurosci (2004) 2.50

Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys. Science (1998) 2.32

Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol Learn Mem (2002) 2.25

Role of adaptive plasticity in recovery of function after damage to motor cortex. Muscle Nerve (2001) 2.20

Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery. J Neurophysiol (2003) 1.89

Plasticity of cortical projections after stroke. Neuroscientist (2003) 1.86

Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: a feasibility study in primates. Neurol Res (2003) 1.74

Different forms of synaptic plasticity in somatosensory and motor areas of the neocortex. J Neurosci (1995) 1.70

The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron (2005) 1.66

Sensorimotor integration in the precentral gyrus: polysensory neurons and defensive movements. J Neurophysiol (2003) 1.66

The cortical control of movement revisited. Neuron (2002) 1.65

Stimulating research on motor cortex. Nat Neurosci (2002) 1.64

Adaptive plasticity in motor cortex: implications for rehabilitation after brain injury. J Rehabil Med (2003) 1.62

The motor cortex and the coding of force. Science (1992) 1.61

Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J Neurosci (1996) 1.61

Use-dependent growth of pyramidal neurons after neocortical damage. J Neurosci (1994) 1.60

Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci (1999) 1.59

Motor enrichment and the induction of plasticity before or after brain injury. Neurochem Res (2003) 1.57

Large-scale reorganization at multiple levels of the somatosensory pathway follows therapeutic amputation of the hand in monkeys. J Neurosci (1995) 1.51

Microstimulation reveals specialized subregions for different complex movements in posterior parietal cortex of prosimian galagos. Proc Natl Acad Sci U S A (2005) 1.47

Complex movements evoked by microstimulation of the ventral intraparietal area. Proc Natl Acad Sci U S A (2003) 1.45

Plasticity of primary somatosensory cortex paralleling sensorimotor skill recovery from stroke in adult monkeys. J Neurophysiol (1998) 1.37

Synaptogenesis and dendritic growth in the cortex opposite unilateral sensorimotor cortex damage in adult rats: a quantitative electron microscopic examination. Brain Res (1996) 1.27

Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat. Neuropharmacology (2000) 1.27

Early skill learning is expressed through selection and tuning of cortically represented muscle synergies. J Neurosci (2003) 1.20

Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period. Brain Res (1998) 1.15

Effects of postlesion experience on behavioral recovery and neurophysiologic reorganization after cortical injury in primates. Neurorehabil Neural Repair (2000) 1.15

Dexterity in adult monkeys following early lesion of the motor cortical hand area: the role of cortex adjacent to the lesion. Eur J Neurosci (1998) 1.15

Changes in motor cortex activity during reaching movements with similar hand paths but different arm postures. J Neurophysiol (1995) 1.13

Motor cortical activity during drawing movements: population representation during lemniscate tracing. J Neurophysiol (1999) 1.07

Functional recovery of forelimb response capacity after forelimb primary motor cortex damage in the rat is due to the reorganization of adjacent areas of cortex. Neuroscience (1995) 1.06

Distribution of hand location in monkeys during spontaneous behavior. Exp Brain Res (2003) 1.03

Quantitative analyses of thalamic and cortical origins of neurons projecting to the rostral and caudal forelimb motor areas in the cerebral cortex of rats. Brain Res (1998) 1.02

Mapping from motor cortex to biceps and triceps altered by elbow angle. J Neurophysiol (2004) 1.01

Modulation of sustained electromyographic activity by single intracortical microstimuli: comparison of two forelimb motor cortical areas of the rat. Somatosens Mot Res (1993) 1.00

Long-Evans and Sprague-Dawley rats have similar skilled reaching success and limb representations in motor cortex but different movements: some cautionary insights into the selection of rat strains for neurobiological motor research. Behav Brain Res (2003) 0.97

Super-flinchers and nerves of steel: defensive movements altered by chemical manipulation of a cortical motor area. Neuron (2004) 0.94

Long-Evans rats have a larger cortical topographic representation of movement than Fischer-344 rats: a microstimulation study of motor cortex in naïve and skilled reaching-trained rats. Brain Res Bull (2002) 0.93

Sensory loss and cortical reorganization in mature primates. Prog Brain Res (2002) 0.89

Probing cortical function with electrical stimulation. Nat Neurosci (2002) 0.82

Transfer of Function to a Specific Area of the Cortex After Induced Recovery from Brain Damage. Eur J Neurosci (1992) 0.80

Articles by these authors

A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimers Dement (2008) 6.39

Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell (2012) 5.15

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11

Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov (2011) 2.65

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron (2003) 2.52

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci (2009) 2.42

The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol (2003) 2.28

Motor axonal regeneration after partial and complete spinal cord transection. J Neurosci (2012) 2.21

Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci (2004) 2.14

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci (2002) 2.03

Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci (2010) 2.02

JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron (2012) 1.80

Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron (2009) 1.76

Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci (2006) 1.73

The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury. Neuron (2005) 1.66

Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res (2004) 1.61

Guidance molecules in axon regeneration. Cold Spring Harb Perspect Biol (2010) 1.55

Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition. J Neurosci (2003) 1.52

Efficient retrograde neuronal transduction utilizing self-complementary AAV1. Mol Ther (2007) 1.51

Hippocampal cell genesis does not correlate with spatial learning ability in aged rats. J Comp Neurol (2003) 1.50

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development. Trends Neurosci (2008) 1.49

Growth factors and combinatorial therapies for CNS regeneration. Exp Neurol (2007) 1.44

Freeze-dried agarose scaffolds with uniaxial channels stimulate and guide linear axonal growth following spinal cord injury. Biomaterials (2005) 1.41

Extensive spinal decussation and bilateral termination of cervical corticospinal projections in rhesus monkeys. J Comp Neurol (2009) 1.39

Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation. Proc Natl Acad Sci U S A (2009) 1.39

Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci (2008) 1.36

Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol (2006) 1.36

Bilateral corticospinal projections arise from each motor cortex in the macaque monkey: a quantitative study. J Comp Neurol (2004) 1.35

Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain (2005) 1.32

Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci (2006) 1.30

Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J Neurophysiol (2005) 1.27

Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol (2003) 1.22

Templated agarose scaffolds support linear axonal regeneration. Tissue Eng (2006) 1.21

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury. Exp Neurol (2008) 1.19

The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials (2004) 1.18

Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J Neurosci (2004) 1.17

Age-related cognitive deficits in rhesus monkeys mirror human deficits on an automated test battery. Neurobiol Aging (2008) 1.17

Local and remote growth factor effects after primate spinal cord injury. J Neurosci (2010) 1.12

Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth. J Comp Neurol (2002) 1.11

Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord (2007) 1.10

Regeneration of long-tract axons through sites of spinal cord injury using templated agarose scaffolds. Biomaterials (2010) 1.07

Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Exp Neurol (2011) 1.04

Structural plasticity within highly specific neuronal populations identifies a unique parcellation of motor learning in the adult brain. Proc Natl Acad Sci U S A (2011) 1.02

The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity. J Neurosci (2009) 1.01

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci (2013) 1.01

Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. J Neurosci (2002) 1.01

Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci (2007) 1.01

Estrogen receptor-beta colocalizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. J Comp Neurol (2002) 0.99

Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair. Brain Res Bull (2002) 0.97

NGF is essential for hippocampal plasticity and learning. J Neurosci (2009) 0.96

Estradiol-induced modulation of estrogen receptor-beta and GABA within the adult neocortex: a potential transsynaptic mechanism for estrogen modulation of BDNF. J Comp Neurol (2006) 0.96

Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther (2005) 0.96

Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics (2012) 0.95

Olfactory ensheathing cells do not exhibit unique migratory or axonal growth-promoting properties after spinal cord injury. J Neurosci (2006) 0.93

Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol (2008) 0.92

Time Controlled Protein Release from Layer-by-Layer Assembled Multilayer Functionalized Agarose Hydrogels. Adv Funct Mater (2010) 0.92

Neurotrophins: potential therapeutic tools for the treatment of spinal cord injury. Neurotherapeutics (2011) 0.91

Clinical trials in spinal cord injury. J Neurotrauma (2006) 0.90

Development of a database for translational spinal cord injury research. J Neurotrauma (2014) 0.90

Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection. Biomaterials (2012) 0.89

Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration. J Biol Chem (2013) 0.89

Unconstrained three-dimensional reaching in rhesus monkeys. Exp Brain Res (2010) 0.89

Transient demyelination increases the efficiency of retrograde AAV transduction. Mol Ther (2010) 0.88

Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury. Adv Exp Med Biol (2012) 0.87

Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair (2012) 0.86

Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res (2002) 0.86

A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth. J Neurosci Res (2009) 0.83

Gene therapy, neurotrophic factors and spinal cord regeneration. Handb Clin Neurol (2012) 0.80

Nerve growth factor, neuropeptides, and mast cells in ultraviolet-B-induced systemic suppression of contact hypersensitivity responses in mice. J Invest Dermatol (2002) 0.79

SnoN facilitates axonal regeneration after spinal cord injury. PLoS One (2013) 0.77

Association of early experience with neurodegeneration in aged primates. Neurobiol Aging (2009) 0.77

Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury. Yonsei Med J (2004) 0.77

Rebuilding the brain: resurgence of fetal grafting. Nat Neurosci (2007) 0.76

Guest editorial: Opportunities in rehabilitation research. J Rehabil Res Dev (2013) 0.75

The ageless question--what accounts for age-related cognitive decline? Sci Aging Knowledge Environ (2004) 0.75

Therapeutic potential of nervous system growth factors for neurodegenerative disease. Expert Rev Neurother (2002) 0.75

Nucleus hears axon's pain. Nat Med (2004) 0.75