Published in J Med Chem on July 27, 2006
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorg Med Chem Lett (2008) 0.85
Path-integral method for predicting relative binding affinities of protein-ligand complexes. J Am Chem Soc (2009) 0.78
Garner's aldehyde as a versatile intermediate in the synthesis of enantiopure natural products. Beilstein J Org Chem (2013) 0.78
Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. Acta Pharmacol Sin (2009) 0.75
Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE). BMC Struct Biol (2012) 0.75
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nat Biotechnol (2005) 2.81
Cyclophilin D as a drug target. Curr Med Chem (2003) 1.87
Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation. Transpl Int (2009) 1.77
Duration of fluid fasting and choice of analgesic are modifiable factors for early postoperative delirium. Eur J Anaesthesiol (2010) 1.59
Long-term effects of neovaginal reconstruction with sigmoid loop technique on sexual function and self image in patients with gynecologic malignancies: results of a prospective study. Gynecol Oncol (2008) 1.48
Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome. Liver Transpl (2008) 1.47
Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. J Pathol (2010) 1.35
Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. Cancer (2009) 1.32
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat Chem Biol (2010) 1.30
Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition. J Pharmacol Exp Ther (2008) 1.28
The diagnosis and treatment of cholangiocarcinoma. Dtsch Arztebl Int (2014) 1.25
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease. Mol Neurodegener (2010) 1.18
Long-term clinical outcome of pelvic exenteration in patients with advanced gynecological malignancies. J Surg Oncol (2010) 1.17
Simultaneous versus staged liver resection of synchronous liver metastases from colorectal cancer. Int J Colorectal Dis (2007) 1.13
Intra-abdominal tumor dissemination pattern and surgical outcome in 214 patients with primary ovarian cancer. J Surg Oncol (2009) 1.10
Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification. Ann Surg (2009) 1.08
Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay. Clin Chem (2006) 1.05
Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis. Infect Immun (2006) 1.04
Wide-range dynamic magnetic resonance elastography. J Biomech (2011) 1.04
Chronic renal dysfunction following liver transplantation. Clin Transplant (2008) 1.04
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem Biol (2013) 1.02
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem (2007) 1.01
Role of IL28B polymorphism in the development of hepatitis C virus-induced hepatocellular carcinoma, graft fibrosis, and posttransplant antiviral therapy. Transplantation (2012) 0.99
Graft versus host disease after liver transplantation - a single center experience and review of literature. Transpl Int (2008) 0.96
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorg Med Chem Lett (2005) 0.94
Liver resection for metastases from breast cancer. J Surg Oncol (2008) 0.94
Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery? World J Surg Oncol (2008) 0.92
Mesenchymal stem cell content of human vertebral bone marrow. Transplantation (2004) 0.92
Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy. Exp Clin Transplant (2011) 0.89
The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. Neoplasia (2007) 0.89
Adjuvant TACE inhibitor treatment improves the outcome of TLR2-/- mice with experimental pneumococcal meningitis. BMC Infect Dis (2007) 0.89
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system. PLoS One (2012) 0.89
Description of B lymphocytes and plasma cells, complement, and chemokines/receptors in acute liver allograft rejection. Transplantation (2004) 0.87
Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation. Br J Pharmacol (2002) 0.87
New Angiopep-modified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J Med Chem (2010) 0.86
Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett (2006) 0.86
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. J Med Chem (2002) 0.86
Vascular CXCR4 expression - a novel antiangiogenic target in gastric cancer? PLoS One (2010) 0.85
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. J Neurochem (2011) 0.85
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Mol Neurodegener (2010) 0.85
Structure-based design and protein X-ray analysis of a protein kinase inhibitor. Bioorg Med Chem Lett (2002) 0.85
Management of biliary complications following living donor liver transplantation--a single center experience. Langenbecks Arch Surg (2009) 0.84
Clinical implications of hepatic preservation injury after adult liver transplantation. Am J Transplant (2003) 0.84
Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor. J Cell Sci (2004) 0.84
The role of vascular CXCR4 expression in colorectal carcinoma. Histopathology (2009) 0.83
Novel scaffold for cathepsin K inhibitors. Bioorg Med Chem Lett (2007) 0.83
Portal capillary C4d deposits and increased infiltration by macrophages indicate humorally mediated mechanisms in acute cellular liver allograft rejection. Virchows Arch (2005) 0.82
Endoscopic ultrasound in pancreatic disease--its influence on surgical decision-making. An update 2008. Pancreatology (2008) 0.82
Conformationally constrained mimics of the membrane-proximal domain of Fc epsilonRIalpha. Chembiochem (2007) 0.82
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem (2005) 0.82
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett (2006) 0.82
Improvement of microsurgical techniques in orthotopic rat liver transplantation. J Surg Res (2008) 0.82
Open surgical is superior to percutaneous access for radiofrequency ablation of hepatic metastases. World J Surg (2009) 0.82
A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines. BMC Complement Altern Med (2011) 0.82
New chemotypes for cathepsin K inhibitors. Bioorg Med Chem Lett (2008) 0.81
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett (2009) 0.81
Improved microcirculation by low-viscosity histidine- tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: results of an orthotopic rat liver transplantation model. Transpl Int (2008) 0.80
Peginterferon alfa-2b plus ribavirin for the treatment of hepatitis C recurrence following combined liver and kidney transplantation. Ann Transplant (2007) 0.80
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases. Neuron (2016) 0.80
Molecular case report: IgVH analysis in acute humoral and cellular liver allograft rejection suggests a selected accumulation of effector B cells and plasma cells. Virchows Arch (2005) 0.79
Protein crystallization in stirred systems--scale-up via the maximum local energy dissipation. Biotechnol Bioeng (2013) 0.79
Endoscopic management of biliary obstruction after successful reuse of a liver graft. Ann Transplant (2009) 0.79
Substrate-controlled and organocatalytic asymmetric synthesis of carbocyclic amino acid dipeptide mimetics. J Org Chem (2010) 0.79
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett (2009) 0.79
Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation. Eur Surg Res (2006) 0.78
Antiviral treatment of patients with recurrent hepatitis C after liver transplantation with pegylated interferon. Dig Dis Sci (2009) 0.78
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg Med Chem Lett (2011) 0.78
Biweekly pegylated liposomal doxorubicin as second-line treatment in patients with relapsed ovarian cancer after failure of platinum and paclitaxel: results from a multi-center phase II study of the NOGGO. Anticancer Res (2008) 0.78
Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides. J Med Chem (2012) 0.77
Diagnostic accuracy of diffusion-weighted magnetic resonance imaging versus positron emission tomography/computed tomography for early response assessment of liver metastases to Y90-radioembolization. Invest Radiol (2015) 0.77
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett (2009) 0.77
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid β-peptides. Bioorg Med Chem Lett (2013) 0.76
Effects of stimulus with proinflammatory mediators on nitric oxide production and matrix metalloproteinase activity in explants of cranial cruciate ligaments obtained from dogs. Am J Vet Res (2002) 0.76
Successful endoscopic and surgical management of non-anastomotic biliary strictures after liver transplantation - case report. Ann Transplant (2009) 0.76
Yeast growth selection system for the identification of cell-active inhibitors of beta-secretase. Biochim Biophys Acta (2004) 0.76
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett (2010) 0.76