Published in Mol Biochem Parasitol on July 10, 2006
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe (2008) 2.98
Transcriptional variation in the malaria parasite Plasmodium falciparum. Genome Res (2012) 2.15
Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. J Infect Dis (2010) 1.77
Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog (2007) 1.63
Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. BMC Genomics (2008) 1.23
Make it or take it: fatty acid metabolism of apicomplexan parasites. Eukaryot Cell (2007) 1.20
Prospective identification of malaria parasite genes under balancing selection. PLoS One (2009) 1.18
Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya. Sci Rep (2013) 1.07
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Mol Biol Evol (2012) 1.00
Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop (2011) 0.95
Hypervariable antigen genes in malaria have ancient roots. BMC Evol Biol (2013) 0.90
Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways. J Lipid Res (2010) 0.90
Protein targeting to the parasitophorous vacuole membrane of Plasmodium falciparum. Eukaryot Cell (2011) 0.86
Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba. PLoS Negl Trop Dis (2011) 0.81
Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus. J Mol Evol (2009) 0.75
Triple Combination Therapy and Drug Cycling-Tangential Strategies for Countering Artemisinin Resistance. Curr Infect Dis Rep (2017) 0.75
GeneMerge--post-genomic analysis, data mining, and hypothesis testing. Bioinformatics (2003) 9.27
Darwinian evolution can follow only very few mutational paths to fitter proteins. Science (2006) 9.07
Variation in genome-wide mutation rates within and between human families. Nat Genet (2011) 8.84
A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A (2008) 5.90
Sex-dependent gene expression and evolution of the Drosophila transcriptome. Science (2003) 5.67
Missense meanderings in sequence space: a biophysical view of protein evolution. Nat Rev Genet (2005) 4.67
A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50
Pathway Processor: a tool for integrating whole-genome expression results into metabolic networks. Genome Res (2002) 4.14
Selection for short introns in highly expressed genes. Nat Genet (2002) 4.04
The cost of inbreeding in Arabidopsis. Nature (2002) 3.80
Direct measure of the de novo mutation rate in autism and schizophrenia cohorts. Am J Hum Genet (2010) 3.69
Rapid evolution of male-biased gene expression in Drosophila. Proc Natl Acad Sci U S A (2003) 3.45
Genetic properties influencing the evolvability of gene expression. Science (2007) 3.45
Research capacity. Enabling the genomic revolution in Africa. Science (2014) 3.05
A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog (2006) 2.92
Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science (2008) 2.86
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nat Genet (2011) 2.86
Bayesian analysis of gene expression levels: statistical quantification of relative mRNA level across multiple strains or treatments. Genome Biol (2002) 2.79
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother (2006) 2.70
Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics (2003) 2.68
Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc Natl Acad Sci U S A (2009) 2.57
A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malar J (2008) 2.54
Plasmodium falciparum clearance rates in response to artesunate in Malian children with malaria: effect of acquired immunity. J Infect Dis (2013) 2.47
Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions. Mol Biol Evol (2005) 2.42
Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection. J Mol Evol (2003) 2.39
Population genetic variation in genome-wide gene expression. Mol Biol Evol (2003) 2.28
Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J (2007) 2.26
A portrait of copy-number polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 2.24
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast. Proc Natl Acad Sci U S A (2010) 2.23
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis (2007) 2.11
Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A (2007) 2.11
Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proc Natl Acad Sci U S A (2010) 2.01
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol (2008) 2.00
Rates of divergence in gene expression profiles of primates, mice, and flies: stabilizing selection and variability among functional categories. Evolution (2005) 1.93
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics (2005) 1.93
Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene (2008) 1.89
Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. I. Differential accumulation of hybrid male sterility effects on the X and autosomes. Genetics (2003) 1.86
Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis. Proc Natl Acad Sci U S A (2005) 1.72
Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans. Genome Res (2004) 1.72
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. PLoS Biol (2007) 1.69
Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data. Theor Popul Biol (2003) 1.69
Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Mol Ecol (2008) 1.69
Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg (2010) 1.69
Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol (2004) 1.68
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet (2011) 1.68
Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. Genetics (2008) 1.67
Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression. Proc Natl Acad Sci U S A (2008) 1.67
In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg (2002) 1.66
cis-Regulatory and protein evolution in orthologous and duplicate genes. Genome Res (2004) 1.65
Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proc Natl Acad Sci U S A (2007) 1.63
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. PLoS Biol (2007) 1.63
Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol (2011) 1.61
Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1. Proc Natl Acad Sci U S A (2009) 1.60
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58
A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol (2010) 1.57
Genome evolution and developmental constraint in Caenorhabditis elegans. Mol Biol Evol (2002) 1.54
Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila. Mol Biol Evol (2008) 1.54
A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents. Mol Biol Evol (2002) 1.54
Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation. Genetics (2004) 1.53
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (2002) 1.52
Optimization of gene expression by natural selection. Proc Natl Acad Sci U S A (2009) 1.50
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J Infect Dis (2011) 1.49
Compensated deleterious mutations in insect genomes. Science (2004) 1.48
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis (2005) 1.46
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem (2010) 1.46
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
Genome-wide scan reveals that genetic variation for transcriptional plasticity in yeast is biased towards multi-copy and dispensable genes. Gene (2006) 1.43
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem (2009) 1.42
The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint. Genome Res (2004) 1.41
Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS One (2013) 1.40
Patterns of insertion and deletion in contrasting chromatin domains. Mol Biol Evol (2002) 1.38