Published in Proc Natl Acad Sci U S A on August 23, 2010
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration. Nat Rev Genet (2013) 2.08
Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb Perspect Biol (2013) 1.76
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet (2014) 1.74
The evolutionary causes and consequences of sex-biased gene expression. Nat Rev Genet (2013) 1.50
The end of gonad-centric sex determination in mammals. Trends Genet (2011) 1.39
The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease. Genome Res (2013) 1.10
Mutagenesis. Smoking is associated with mosaic loss of chromosome Y. Science (2014) 1.08
W chromosome expression responds to female-specific selection. Proc Natl Acad Sci U S A (2012) 1.05
Differences between male and female systemic lupus erythematosus in a multiethnic population. J Rheumatol (2012) 1.03
Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila. Proc Natl Acad Sci U S A (2011) 0.99
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What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation. Handb Exp Pharmacol (2012) 0.92
Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game. Exp Neurol (2014) 0.92
The contribution of the Y chromosome to hybrid male sterility in house mice. Genetics (2012) 0.91
Male-specific Fruitless isoforms have different regulatory roles conferred by distinct zinc finger DNA binding domains. BMC Genomics (2013) 0.90
How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression. J Genomics (2014) 0.88
Correlated variation and population differentiation in satellite DNA abundance among lines of Drosophila melanogaster. Proc Natl Acad Sci U S A (2014) 0.88
Natural variation of the Y chromosome suppresses sex ratio distortion and modulates testis-specific gene expression in Drosophila simulans. Heredity (Edinb) (2013) 0.87
The importance of having two X chromosomes. Philos Trans R Soc Lond B Biol Sci (2016) 0.86
A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster. Genetics (2012) 0.86
INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue. PLoS One (2011) 0.85
The chromatin landscape of Drosophila: comparisons between species, sexes, and chromosomes. Genome Res (2014) 0.85
Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proc Natl Acad Sci U S A (2016) 0.82
The genetics of sex chromosomes: evolution and implications for hybrid incompatibility. Ann N Y Acad Sci (2012) 0.82
Chromosome y regulates survival following murine coxsackievirus b3 infection. G3 (Bethesda) (2012) 0.82
Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster. Genetics (2012) 0.82
A distinct type of heterochromatin at the telomeric region of the Drosophila melanogaster Y chromosome. PLoS One (2014) 0.82
Genome-wide gene expression effects of sex chromosome imprinting in Drosophila. G3 (Bethesda) (2014) 0.81
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Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis. Genetics (2013) 0.80
Chromosome Y genetic variants: impact in animal models and on human disease. Physiol Genomics (2015) 0.80
Spermatogenic failure and the Y chromosome. Hum Genet (2017) 0.79
Sex-biased chromatin and regulatory cross-talk between sex chromosomes, autosomes, and mitochondria. Biol Sex Differ (2014) 0.79
Normal segregation of a foreign-species chromosome during Drosophila female meiosis despite extensive heterochromatin divergence. Genetics (2014) 0.78
Transcriptome Differences between Alternative Sex Determining Genotypes in the House Fly, Musca domestica. Genome Biol Evol (2015) 0.77
Epigenetics and sex-specific fitness: an experimental test using male-limited evolution in Drosophila melanogaster. PLoS One (2013) 0.77
Never settling down: frequent changes in sex chromosomes. PLoS Biol (2015) 0.77
A general theory of sexual differentiation. J Neurosci Res (2017) 0.77
Genetics: polymorphisms, epigenetics, and something in between. Genet Res Int (2011) 0.76
Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin. Genome Biol Evol (2013) 0.76
Y-linked variation for autosomal immune gene regulation has the potential to shape sexually dimorphic immunity. Proc Biol Sci (2015) 0.76
A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues. Biol Sex Differ (2016) 0.76
Evidence for a sexual dimorphism in gene expression noise in metazoan species. PeerJ (2015) 0.76
Interspecific Y chromosome variation is sufficient to rescue hybrid male sterility and is influenced by the grandparental origin of the chromosomes. Heredity (Edinb) (2016) 0.76
The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity. Curr Opin Endocrinol Diabetes Obes (2016) 0.75
Matrilineal inheritance of a key mediator of prenatal maternal effects. Proc Biol Sci (2016) 0.75
Genetic variation: Y variants tip the chromatin balance. Nat Rev Genet (2010) 0.75
Endogenously imprinted genes in Drosophila melanogaster. Mol Genet Genomics (2014) 0.75
Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Heredity (Edinb) (2016) 0.75
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res (2002) 28.38
GeneMerge--post-genomic analysis, data mining, and hypothesis testing. Bioinformatics (2003) 9.27
Position effect variegation and chromatin proteins. Bioessays (1992) 4.24
Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell (1997) 4.02
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Science (2007) 2.97
Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science (2008) 2.86
Bayesian analysis of gene expression levels: statistical quantification of relative mRNA level across multiple strains or treatments. Genome Biol (2002) 2.79
Functional elements in Drosophila melanogaster heterochromatin. Annu Rev Genet (1992) 2.59
Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila. J Cell Biol (1998) 1.90
Male fitness increases when females are eliminated from gene pool: implications for the Y chromosome. Proc Natl Acad Sci U S A (1998) 1.81
Y chromosome polymorphism is a strong determinant of male fitness in Drosophila melanogaster. Proc Natl Acad Sci U S A (2001) 1.75
Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin. Gene (2007) 1.73
The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster. Genetics (1991) 1.71
Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila. PLoS Genet (2005) 1.57
Lack of nucleotide polymorphism in the Y-linked sperm flagellar dynein gene Dhc-Yh3 of Drosophila melanogaster and D. simulans. Genetics (1999) 1.56
Origin and evolution of Y chromosomes: Drosophila tales. Trends Genet (2009) 1.53
Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster. Mol Cell (2000) 1.52
Natural selection and Y-linked polymorphism. Genetics (1987) 1.47
Polymorphism for Y-linked suppressors of sex-ratio in two natural populations of Drosophila mediopunctata. Genetics (1997) 1.45
Position effect variegation in Drosophila melanogaster: relationship between suppression effect and the amount of Y chromosome. Genetics (1989) 1.45
Ribosomal DNA and Stellate gene copy number variation on the Y chromosome of Drosophila melanogaster. Proc Natl Acad Sci U S A (1989) 1.41
Ribosomal DNA contributes to global chromatin regulation. Proc Natl Acad Sci U S A (2009) 1.40
Sexually antagonistic "zygotic drive" of the sex chromosomes. PLoS Genet (2008) 1.34
Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster. Annu Rev Entomol (2007) 1.23
Resolving intralocus sexual conflict: genetic mechanisms and time frame. J Hered (2010) 1.19
Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem (2007) 1.19
Functional copies of the Mst77F gene on the Y chromosome of Drosophila melanogaster. Genetics (2009) 1.13
Heat induced male sterility in Drosophila melanogaster: adaptive genetic variations among geographic populations and role of the Y chromosome. J Exp Biol (2004) 1.12
Satellite DNA in insects: a review. Heredity (Edinb) (2008) 1.11
Intralocus sexual conflict over immune defense, gender load, and sex-specific signaling in a natural lizard population. Evolution (2009) 1.02
Spermiogenesis in wild type and in a male sterility mutant of Drosophila melanogaster. J Cell Biol (1967) 0.99
Complex inheritance of male courtship song characters in Drosophila virilis. Behav Genet (2003) 0.92
Modification of position-effect variegation by competition for binding to Drosophila satellites. EMBO Rep (2002) 0.90
A trans-activator on the Drosophila Y chromosome regulates gene expression in the male germ line. Genetica (2000) 0.86
Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes. Genetics (2006) 0.85
The sex chromosome that refused to die. Bioessays (2008) 0.84
Genetics. Functionally degenerate--Y not so? Science (2008) 0.80
GeneMerge--post-genomic analysis, data mining, and hypothesis testing. Bioinformatics (2003) 9.27
Darwinian evolution can follow only very few mutational paths to fitter proteins. Science (2006) 9.07
A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A (2008) 5.90
Sex-dependent gene expression and evolution of the Drosophila transcriptome. Science (2003) 5.67
Missense meanderings in sequence space: a biophysical view of protein evolution. Nat Rev Genet (2005) 4.67
A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50
Pathway Processor: a tool for integrating whole-genome expression results into metabolic networks. Genome Res (2002) 4.14
Selection for short introns in highly expressed genes. Nat Genet (2002) 4.04
The cost of inbreeding in Arabidopsis. Nature (2002) 3.80
Rapid evolution of male-biased gene expression in Drosophila. Proc Natl Acad Sci U S A (2003) 3.45
Genetic properties influencing the evolvability of gene expression. Science (2007) 3.45
Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science (2008) 2.86
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nat Genet (2011) 2.86
Bayesian analysis of gene expression levels: statistical quantification of relative mRNA level across multiple strains or treatments. Genome Biol (2002) 2.79
Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics (2003) 2.68
Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc Natl Acad Sci U S A (2009) 2.57
Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions. Mol Biol Evol (2005) 2.42
Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection. J Mol Evol (2003) 2.39
Population genetic variation in genome-wide gene expression. Mol Biol Evol (2003) 2.28
A portrait of copy-number polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 2.24
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast. Proc Natl Acad Sci U S A (2010) 2.23
Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis (2007) 2.11
Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A (2007) 2.11
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol (2008) 2.00
Rates of divergence in gene expression profiles of primates, mice, and flies: stabilizing selection and variability among functional categories. Evolution (2005) 1.93
Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics (2005) 1.93
Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene (2008) 1.89
Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. I. Differential accumulation of hybrid male sterility effects on the X and autosomes. Genetics (2003) 1.86
Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis. Proc Natl Acad Sci U S A (2005) 1.72
Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans. Genome Res (2004) 1.72
A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. PLoS Biol (2007) 1.69
Maximum likelihood and Bayesian methods for estimating the distribution of selective effects among classes of mutations using DNA polymorphism data. Theor Popul Biol (2003) 1.69
Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Mol Ecol (2008) 1.69
Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg (2010) 1.69
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet (2011) 1.68
Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression. Proc Natl Acad Sci U S A (2008) 1.67
cis-Regulatory and protein evolution in orthologous and duplicate genes. Genome Res (2004) 1.65
Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proc Natl Acad Sci U S A (2007) 1.63
A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. PLoS Biol (2007) 1.63
Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1. Proc Natl Acad Sci U S A (2009) 1.60
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58
Genome evolution and developmental constraint in Caenorhabditis elegans. Mol Biol Evol (2002) 1.54
A maximum likelihood method for analyzing pseudogene evolution: implications for silent site evolution in humans and rodents. Mol Biol Evol (2002) 1.54
Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila. Mol Biol Evol (2008) 1.54
Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation. Genetics (2004) 1.53
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (2002) 1.52
Optimization of gene expression by natural selection. Proc Natl Acad Sci U S A (2009) 1.50
Compensated deleterious mutations in insect genomes. Science (2004) 1.48
Genome-wide scan reveals that genetic variation for transcriptional plasticity in yeast is biased towards multi-copy and dispensable genes. Gene (2006) 1.43
The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint. Genome Res (2004) 1.41
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS One (2013) 1.40
Patterns of insertion and deletion in contrasting chromatin domains. Mol Biol Evol (2002) 1.38
On the abundance, amino acid composition, and evolutionary dynamics of low-complexity regions in proteins. Gene (2006) 1.37
Evidence for S. cerevisiae fermentation in ancient wine. J Mol Evol (2003) 1.37
Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol Evol (2009) 1.36
Colloquium papers: Adaptive landscapes and protein evolution. Proc Natl Acad Sci U S A (2009) 1.36
Population genomics of inversion polymorphisms in Drosophila melanogaster. PLoS Genet (2012) 1.35
Key considerations for measuring allelic expression on a genomic scale using high-throughput sequencing. Mol Ecol (2010) 1.30
Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. Genetics (2003) 1.30
Genetic incompatibilities are widespread within species. Nature (2013) 1.28
Compensatory mutations restore fitness during the evolution of dihydrofolate reductase. Mol Biol Evol (2010) 1.27
Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation. PLoS Genet (2011) 1.27
Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number. Genome Res (2006) 1.26
Mutational reversions during adaptive protein evolution. Mol Biol Evol (2007) 1.24
Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol (2010) 1.23
Ecological and evolutionary genomics of Saccharomyces cerevisiae. Mol Ecol (2006) 1.23
Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster. Genome Biol Evol (2011) 1.21
Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Mol Biol Evol (2003) 1.19
Regulatory evolution across the protein interaction network. Nat Genet (2004) 1.15
Formation and longevity of chimeric and duplicate genes in Drosophila melanogaster. Genetics (2008) 1.12
Plasmodium falciparum: worldwide sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-2 (MSP-2). Exp Parasitol (2006) 1.12
Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol Biochem Parasitol (2006) 1.11
Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease. Proc Natl Acad Sci U S A (2013) 1.10
Unexpected stability of mariner transgenes in Drosophila. Genetics (2002) 1.10
Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster. Genetics (2010) 1.09
Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites. Mol Biol Evol (2004) 1.09
Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin. PLoS Genet (2007) 1.09
DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A (2013) 1.08
Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum. PLoS One (2011) 1.08
Horizontal acquisition of divergent chromosomal DNA in bacteria: effects of mutator phenotypes. Genetics (2003) 1.06
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc Natl Acad Sci U S A (2013) 1.05
The evolutionary landscape of antifolate resistance in Plasmodium falciparum. J Genet (2011) 1.01
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Mol Biol Evol (2012) 1.00
Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila. Proc Natl Acad Sci U S A (2011) 0.99
Malaria life cycle intensifies both natural selection and random genetic drift. Proc Natl Acad Sci U S A (2013) 0.99
Chimeric genes as a source of rapid evolution in Drosophila melanogaster. Mol Biol Evol (2011) 0.99
Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila. Mol Biol Evol (2008) 0.97
Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Proc Natl Acad Sci U S A (2010) 0.96
Origin and evolution of a new gene expressed in the Drosophila sperm axoneme. Genetica (2003) 0.96
The roles of cis- and trans-regulation in the evolution of regulatory incompatibilities and sexually dimorphic gene expression. Genome Res (2013) 0.95
Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop (2011) 0.95
Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila. Proc Natl Acad Sci U S A (2012) 0.93
Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition. Proc Natl Acad Sci U S A (2012) 0.92
Different regulatory mechanisms underlie similar transposable element profiles in pufferfish and fruitflies. Mol Biol Evol (2004) 0.92
Overdispersion of the molecular clock varies between yeast, Drosophila and mammals. Genetics (2008) 0.90
Recurrent selection on the Winters sex-ratio genes in Drosophila simulans. Genetics (2009) 0.90
Efficient mobilization of mariner in vivo requires multiple internal sequences. Genetics (2002) 0.89
Evolution of noncoding and silent coding sites in the Plasmodium falciparum and Plasmodium reichenowi genomes. Mol Biol Evol (2005) 0.89