Published in Autophagy on October 25, 2006
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Autophagy in ischemic heart disease. Circ Res (2009) 2.20
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol (2008) 1.97
Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia-reperfusion in mice. FEBS Lett (2008) 1.77
Autophagy in health and disease. 5. Mitophagy as a way of life. Am J Physiol Cell Physiol (2010) 1.72
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Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy (2010) 1.58
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The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ (2009) 1.53
Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy (2010) 1.42
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol (2009) 1.38
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem (2012) 1.29
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Mitochondrial turnover in the heart. Biochim Biophys Acta (2010) 1.23
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Cardiac O-GlcNAcylation blunts autophagic signaling in the diabetic heart. Life Sci (2012) 1.01
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Mol Biol Cell (2010) 0.99
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Programmed cell death in cardiac myocytes: strategies to maximize post-ischemic salvage. Heart Fail Rev (2008) 0.94
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Untangling autophagy measurements: all fluxed up. Circ Res (2015) 0.93
Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis. J Biol Chem (2008) 0.92
Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress. Mol Cell Biol (2015) 0.91
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Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. Am J Physiol Cell Physiol (2011) 0.89
Mitochondrial therapeutics for cardioprotection. Curr Pharm Des (2011) 0.89
Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proc Natl Acad Sci U S A (2014) 0.88
Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. PLoS One (2014) 0.87
How does the heart (not) die? The role of autophagy in cardiomyocyte homeostasis and cell death. Heart Fail Rev (2010) 0.87
Molecular mechanisms mediating preconditioning following chronic ischemia differ from those in classical second window. Am J Physiol Heart Circ Physiol (2010) 0.86
Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: role of Bnip3 and Pdk1. Shock (2010) 0.86
Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death. Biochim Biophys Acta (2010) 0.83
Role of cell death in the progression of heart failure. Heart Fail Rev (2016) 0.81
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Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Targeting BNIP3 in inflammation-mediated heart failure: a novel concept in heart failure therapy. Heart Fail Rev (2016) 0.79
Loss of Sirt3 limits bone marrow cell-mediated angiogenesis and cardiac repair in post-myocardial infarction. PLoS One (2014) 0.77
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Nipping at cardiac remodeling. J Clin Invest (2007) 0.76
Role of autophagy in chronic kidney diseases. Int J Clin Exp Med (2015) 0.75
Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis. Cell Commun Signal (2015) 0.75
PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival. J Cell Biol (2015) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J Biol Chem (2006) 4.57
A method to measure cardiac autophagic flux in vivo. Autophagy (2008) 2.72
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biol (2003) 2.47
Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One (2011) 2.21
Autophagy in ischemic heart disease. Circ Res (2009) 2.20
Heart mitochondria: gates of life and death. Cardiovasc Res (2007) 2.18
Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A (2004) 2.11
Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation (2010) 2.06
Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem (2012) 1.98
Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation (2010) 1.97
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. Am J Physiol Heart Circ Physiol (2008) 1.97
Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol (2006) 1.88
Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J (2007) 1.76
Role of apoptosis in cardiovascular disease. Apoptosis (2009) 1.74
Lysophosphatidic acid induces hypertrophy of neonatal cardiac myocytes via activation of Gi and Rho. J Mol Cell Cardiol (2004) 1.71
The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores. FEBS J (2007) 1.67
New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation (2011) 1.66
Calpain and mitochondria in ischemia/reperfusion injury. J Biol Chem (2002) 1.62
Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol (2008) 1.61
Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy (2010) 1.58
Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol (2008) 1.58
Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J Biol Chem (2004) 1.58
Cytochrome c dissociation and release from mitochondria by truncated Bid and ceramide. Mitochondrion (2003) 1.56
Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biol (2011) 1.51
Disruption of neuronal autophagy by infected microglia results in neurodegeneration. PLoS One (2008) 1.50
Novel methods for measuring cardiac autophagy in vivo. Methods Enzymol (2009) 1.43
Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res (2010) 1.43
Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy (2010) 1.42
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem (2010) 1.41
A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria. Antioxid Redox Signal (2006) 1.40
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol (2009) 1.38
Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective. Biochem J (2002) 1.36
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Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem (2012) 1.29
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Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. J Mol Cell Cardiol (2009) 1.22
Pim-1 kinase protects mitochondrial integrity in cardiomyocytes. Circ Res (2010) 1.21
TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective. Circulation (2002) 1.20
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol (2009) 1.18
Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. J Biol Chem (2012) 1.16
Ischemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol (2004) 1.16
Mitophagy is required for acute cardioprotection by simvastatin. Antioxid Redox Signal (2013) 1.14
Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev (2012) 1.13
Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury. J Cardiovasc Pharmacol Ther (2010) 1.10
Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion. Autophagy (2008) 1.06
Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors. Biochim Biophys Acta (2006) 1.06
Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis. Infect Immun (2011) 1.06
New roles for mitochondria in cell death in the reperfused myocardium. Cardiovasc Res (2011) 1.03
MitoTimer: a novel tool for monitoring mitochondrial turnover. Autophagy (2013) 1.02
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovasc Res (2011) 1.01
Histone deacetylase 10 promotes autophagy-mediated cell survival. Proc Natl Acad Sci U S A (2013) 1.01
Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes. Commun Integr Biol (2013) 0.99
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. J Clin Invest (2013) 0.97
Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6. Am J Physiol Heart Circ Physiol (2006) 0.95
Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. Am J Physiol Cell Physiol (2002) 0.95
Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter. Autophagy (2011) 0.95
The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death. Curr Med Chem (2003) 0.95
Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis. PLoS One (2012) 0.95
Xenotransplantation of mitochondrial electron transfer enzyme, Ndi1, in myocardial reperfusion injury. PLoS One (2011) 0.94
Activation of the homeostatic intracellular repair response during cardiac surgery. J Am Coll Surg (2013) 0.93
MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy (2013) 0.93
TAT-mediated protein transduction: delivering biologically active proteins to the heart. Methods Mol Med (2005) 0.92
Chemotherapy and cardiotoxicity. Rev Cardiovasc Med (2008) 0.91
Mitochondrial therapeutics for cardioprotection. Curr Pharm Des (2011) 0.89
Autophagy, myocardial protection, and the metabolic syndrome. J Cardiovasc Pharmacol (2012) 0.88
Regulation of autophagy by metabolic and stress signaling pathways in the heart. J Cardiovasc Pharmacol (2012) 0.87
Bnip3-mediated defects in oxidative phosphorylation promote mitophagy. Autophagy (2011) 0.87
Mitochondria: regulators of cell death and survival. ScientificWorldJournal (2002) 0.87
Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay. IUBMB Life (2012) 0.87
Sphingolipid rheostat alterations related to transformation can be exploited for specific induction of lysosomal cell death in murine and human glioma. Glia (2010) 0.86
S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol (2007) 0.85
Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis. Circ J (2013) 0.84
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62. J Virol (2015) 0.83
Systems biological analysis of epidermal growth factor receptor internalization dynamics for altered receptor levels. J Biol Chem (2009) 0.82
The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy (2012) 0.82
Measuring cardiac autophagic flux in vitro and in vivo. Methods Mol Biol (2015) 0.81
Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics. Cell Commun Signal (2014) 0.80
Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas. Autophagy (2013) 0.79
Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity. Autophagy (2013) 0.79
Reduction of infarct size by the therapeutic protein TAT-Ndi1 in vivo. J Cardiovasc Pharmacol Ther (2013) 0.78
Having a heart attack? Avoid the "HETE"! Am J Physiol Heart Circ Physiol (2006) 0.77
MCL1 is critical for mitochondrial function and autophagy in the heart. Autophagy (2013) 0.77
Cell-permeable protein therapy for complex I dysfunction. J Bioenerg Biomembr (2014) 0.77
Debatable contribution of mitochondrial swelling to cell swelling in ischemia. J Mol Cell Cardiol (2003) 0.75