Published in Neurobiol Aging on July 31, 2006
Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PLoS One (2010) 1.07
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IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults. Neurobiol Aging (2013) 0.87
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Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene. BMC Med Genet (2011) 0.80
Redox regulation of insulin degradation by insulin-degrading enzyme. PLoS One (2011) 0.79
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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA (2009) 7.29
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Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol (2013) 6.12
An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol (2004) 5.78
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Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol (2011) 4.63
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol (2006) 4.54
The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol (2005) 4.54
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol (2005) 4.49
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol (2005) 3.95
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Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol (2007) 3.22
Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology (2013) 3.20
Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study. Arch Intern Med (2006) 2.90
Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden. Am J Public Health (2008) 2.86
The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement (2010) 2.75
Apolipoprotein E and cognitive performance: a meta-analysis. Psychol Aging (2004) 2.64
Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study. Stroke (2003) 2.60
Patterns of chronic multimorbidity in the elderly population. J Am Geriatr Soc (2009) 2.54
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Increased mitochondrial mass in mitochondrial myopathy mice. Proc Natl Acad Sci U S A (2002) 2.38
Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease. Am J Epidemiol (2004) 2.35
Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet (2009) 2.31
The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A (2008) 2.30
Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord (2005) 2.19
The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer's disease. Eur Heart J (2013) 2.15
The epidemiology of the dementias: an update. Curr Opin Psychiatry (2007) 2.05
Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers. Neurology (2012) 2.02
Association between mid-life marital status and cognitive function in later life: population based cohort study. BMJ (2009) 2.00
Person-centred care of people with severe Alzheimer's disease: current status and ways forward. Lancet Neurol (2008) 1.86
Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study. Neurobiol Aging (2005) 1.85
An estimate of the total worldwide societal costs of dementia in 2005. Alzheimers Dement (2007) 1.83
A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC). Aging Clin Exp Res (2004) 1.78
Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease. Am J Geriatr Psychiatry (2008) 1.77
Serum lipids and hippocampal volume: the link to Alzheimer's disease? Ann Neurol (2004) 1.72
Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychol Aging (2009) 1.70
Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study. Diabetes (2008) 1.68
Anaemia increases the risk of dementia in cognitively intact elderly. Neurobiol Aging (2006) 1.65
Late-life body mass index and dementia incidence: nine-year follow-up data from the Kungsholmen Project. J Am Geriatr Soc (2007) 1.65
Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study. BMJ (2003) 1.65
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol (2003) 1.64
Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Arch Neurol (2011) 1.62
The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. Diabetes (2007) 1.62
Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol (2011) 1.59
Potentially modifiable risk factors for dementia in identical twins. Alzheimers Dement (2006) 1.55
Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project. Am J Psychiatry (2002) 1.55
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. FEBS J (2005) 1.54
Partial purification and characterization of gamma-secretase from post-mortem human brain. J Biol Chem (2003) 1.54
A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats. Hum Mutat (2013) 1.53
A nine-transmembrane domain topology for presenilin 1. J Biol Chem (2005) 1.52
Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia (2007) 1.51
Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study. BMJ (2004) 1.51
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res (2003) 1.50
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease. Ann Neurol (2008) 1.50
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains. J Neurochem (2009) 1.48
Determinants of costs of care for patients with Alzheimer's disease. Int J Geriatr Psychiatry (2006) 1.47
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease. Acta Neuropathol (2010) 1.46
Phenotype selection for detecting variable genes: a survey of cardiovascular quantitative traits and TNF locus polymorphism. Eur J Hum Genet (2007) 1.45
Drug repositioning for Alzheimer's disease. Nat Rev Drug Discov (2012) 1.42
Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem (2004) 1.39
Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Arch Neurol (2003) 1.36
APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study. Arch Neurol (2004) 1.36
Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J Neuroimmunol (2002) 1.36
Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL. Alzheimer Dis Assoc Disord (2006) 1.35
Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins. J Gerontol A Biol Sci Med Sci (2008) 1.34
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment. BMC Neurol (2002) 1.34
Transcriptome-wide assessment of human brain and lymphocyte senescence. PLoS One (2008) 1.33
Review of Alzheimer's disease scales: is there a need for a new multi-domain scale for therapy evaluation in medical practice? Alzheimers Res Ther (2010) 1.30
The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis (2011) 1.30