Published in Biochemistry on August 08, 2006
Factor XI contributes to thrombin generation in the absence of factor XII. Blood (2009) 2.31
Structure and function of factor XI. Blood (2010) 1.37
Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. J Biol Chem (2008) 1.15
Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X. Blood (2009) 1.09
Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency. Blood (2008) 1.06
Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa. J Biol Chem (2010) 0.99
Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Biochemistry (2009) 0.96
Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients. J Thromb Haemost (2009) 0.95
Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. Crit Care Med (2013) 0.80
The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2. J Biol Chem (2011) 0.79
Mechanism of protein-z-mediated inhibition of coagulation factor xa by z-protein-dependent inhibitor: a molecular dynamic approach. ISRN Hematol (2012) 0.77
Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. J Thromb Haemost (2013) 0.77
Inhibitory properties of the P1 Tyr variant of antithrombin. Biochemistry (2010) 0.75
Factor XI antisense oligonucleotide for prevention of venous thrombosis. N Engl J Med (2014) 4.58
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med (2006) 2.54
Factor XI contributes to thrombin generation in the absence of factor XII. Blood (2009) 2.31
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood (2008) 1.89
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood (2010) 1.83
Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood (2014) 1.81
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol (2009) 1.64
Structure and function of factor XI. Blood (2010) 1.37
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates. Arterioscler Thromb Vasc Biol (2013) 1.30
Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood (2011) 1.22
The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. J Biol Chem (2002) 1.13
Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI. J Biol Chem (2004) 1.10
Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein. J Biol Chem (2001) 1.07
The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex. J Biol Chem (2004) 1.05
The intrinsic pathway of coagulation is essential for thrombus stability in mice. Blood Cells Mol Dis (2006) 1.02
Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation. J Biol Chem (2008) 1.02
Factor XI and XII as antithrombotic targets. Curr Opin Hematol (2011) 1.02
Role of Factor XII in hemostasis and thrombosis: clinical implications. Expert Rev Cardiovasc Ther (2007) 1.00
Activation of factor XI by products of prothrombin activation. Blood (2011) 0.99
Factor V Leiden protects against blood loss and transfusion after cardiac surgery. Circulation (2003) 0.97
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa. J Med Chem (2013) 0.97
Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. Biochemistry (2009) 0.96
Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX. J Biol Chem (2005) 0.95
Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis. J Infect Dis (2008) 0.95
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets. Mol Pharmacol (2013) 0.93
Update on the physiology and pathology of factor IX activation by factor XIa. Expert Rev Hematol (2008) 0.93
Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. J Leukoc Biol (2011) 0.93
A sequential mechanism for exosite-mediated factor IX activation by factor XIa. J Biol Chem (2012) 0.93
Cloning and characterization of the human factor XI gene promoter: transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha ) is required for hepatocyte-specific expression of factor XI. J Biol Chem (2002) 0.92
The dimeric structure of factor XI and zymogen activation. Blood (2013) 0.92
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood (2012) 0.91
Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain. Blood (2004) 0.91
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site. J Med Chem (2013) 0.90
Molecular cloning and biochemical characterization of rabbit factor XI. Biochem J (2002) 0.89
Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice. Transl Stroke Res (2012) 0.88
Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI. J Biol Chem (2004) 0.85
Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis. J Immunol (2013) 0.83
Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis. Infect Immun (2011) 0.81
The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Blood (2005) 0.80
Factor XI protein in human pancreas and kidney. Thromb Haemost (2008) 0.80
A classification system for cross-reactive material-negative factor XI deficiency. Blood (2005) 0.80
Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma. Haematologica (2007) 0.79
Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II. J Biol Chem (2010) 0.79
Immediate recovery of acquired von Willebrand syndrome after left ventricular assist device explantation: implications for heart transplantation. ASAIO J (2014) 0.79
Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa. Biochemistry (2008) 0.79
Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2. Int Immunopharmacol (2002) 0.78
Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation. Anesthesiology (2003) 0.77
Factor XI antisense oligonucleotide for venous thrombosis. N Engl J Med (2015) 0.77
Single-chain factor XII: a new form of activated factor XII. Curr Opin Hematol (2017) 0.75
Acquired factor XI deficiency in a child with membranoproliferative glomerulonephritis. Pediatr Blood Cancer (2011) 0.75
Evidence against a protein in plasma that is a product of a factor XI mRNA splice variant missing exons 6 and 7. Blood (2010) 0.75
The rebirth of the contact pathway: a new therapeutic target. Curr Opin Hematol (2020) 0.75
Defective binding of factor XI-N248 to activated human platelets. Blood (2007) 0.75