AMP-activated protein kinase as a drug target.

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care (2009) 6.17

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest (2010) 5.39

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85

An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell (2008) 3.07

The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab (2009) 2.92

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell (2013) 2.66

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem (2007) 2.54

The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab (2009) 2.39

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res (2009) 2.38

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res (2009) 2.36

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15

AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol (2008) 2.08

AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem (2008) 2.02

Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med (2011) 1.93

Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res (2010) 1.76

From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74

Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res (2008) 1.73

Molecular mechanism of action of metformin: old or new insights? Diabetologia (2013) 1.71

Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. Hypertension (2009) 1.61

Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification. Cell Cycle (2012) 1.57

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. Biochem Biophys Res Commun (2010) 1.50

The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice. J Lipid Res (2009) 1.48

Turning enzymes ON with small molecules. Nat Chem Biol (2010) 1.47

The fat side of prostate cancer. Biochim Biophys Acta (2013) 1.46

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. J Lipid Res (2008) 1.38

PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects. Cell Cycle (2009) 1.38

Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics (2012) 1.38

Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes (2009) 1.31

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. PLoS One (2013) 1.29

Metabolic alterations and targeted therapies in prostate cancer. J Pathol (2010) 1.28

Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle. Diabetes (2011) 1.24

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK. Biochem Biophys Res Commun (2012) 1.19

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med (2014) 1.19

Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice. Hypertension (2010) 1.18

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice. Br J Pharmacol (2011) 1.16

Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin. Stem Cells (2009) 1.14

Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life (2009) 1.14

AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. Bone (2010) 1.11

Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 1.10

Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator. Mol Syst Biol (2009) 1.08

Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer (2011) 1.07

AMPK exerts dual regulatory effects on the PI3K pathway. J Mol Signal (2010) 1.05

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.05

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Res (2014) 1.04

Metformin and survival in pancreatic cancer: a retrospective cohort study. Pancreas (2013) 1.03

Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol (2008) 1.01

Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome. PLoS One (2008) 1.01

Radiosensitization of pancreatic cancer cells by metformin through the AMPK pathway. Radiat Res (2014) 0.99

Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. Rev Diabet Stud (2009) 0.98

Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem (2010) 0.98

Targeting the mitochondria to augment myocardial protection. Curr Opin Pharmacol (2008) 0.97

AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells. PLoS One (2012) 0.96

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun (2009) 0.95

Time-dependent profiling of metabolites from Snf1 mutant and wild type yeast cells. Anal Chem (2008) 0.94

High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes (2009) 0.94

Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance. Mol Cancer Ther (2014) 0.92

Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway. Endocrinology (2008) 0.92

AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK. Mol Endocrinol (2010) 0.92

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. Breast Cancer Res Treat (2011) 0.91

Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis. Proc Am Thorac Soc (2008) 0.91

Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae. Eukaryot Cell (2011) 0.91

Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo. PLoS One (2012) 0.90

Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest (2007) 0.90

ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis. Cancer Lett (2012) 0.89

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis. ACS Med Chem Lett (2010) 0.89

Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol (2014) 0.89

The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression. EMBO J (2009) 0.88

Bitter melon juice activates cellular energy sensor AMP-activated protein kinase causing apoptotic death of human pancreatic carcinoma cells. Carcinogenesis (2013) 0.88

Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats. Croat Med J (2013) 0.87

Targeting the LKB1 tumor suppressor. Curr Drug Targets (2014) 0.87

Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells. J Biol Chem (2012) 0.86

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochem (2010) 0.86

A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation. PLoS One (2009) 0.85

The metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow trout. PLoS One (2011) 0.85

Chemoproteomic analysis of intertissue and interspecies isoform diversity of AMP-activated protein kinase (AMPK). J Biol Chem (2013) 0.85

ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC Complement Altern Med (2011) 0.84

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor. J Carcinog (2013) 0.83

The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetol Metab Syndr (2013) 0.83

Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction. Oncotarget (2015) 0.83

Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice. Diabetes (2013) 0.83

Dietary energy balance modulates ovarian cancer progression and metastasis. Oncotarget (2014) 0.83

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix. J Biol Chem (2009) 0.83

Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications. Prostaglandins Other Lipid Mediat (2011) 0.83

Metabolic shifts during aging and pathology. Compr Physiol (2015) 0.82

AMPK as a potential anticancer target - friend or foe? Curr Pharm Des (2014) 0.82

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators. ACS Med Chem Lett (2013) 0.82

AMPK activators: mechanisms of action and physiological activities. Exp Mol Med (2016) 0.82

Cardiovascular impact of drugs used in the treatment of diabetes. Ther Adv Chronic Dis (2014) 0.82

Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence. Plant Physiol (2016) 0.82

Classification of protein kinases on the basis of both kinase and non-kinase regions. PLoS One (2010) 0.82

Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae. Eukaryot Cell (2009) 0.82

Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One (2013) 0.81

β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages. J Clin Biochem Nutr (2012) 0.81

New mechanisms of metformin action: Focusing on mitochondria and the gut. J Diabetes Investig (2015) 0.80

Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy. Int J Breast Cancer (2013) 0.80