Published in Nat Rev Cancer on August 01, 2009
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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
Autophagy and metabolism. Science (2010) 8.10
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
Targeting metabolic transformation for cancer therapy. Nat Rev Cancer (2010) 5.90
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell (2013) 4.58
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature (2012) 3.85
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 3.62
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature (2010) 3.54
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
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Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23
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Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
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Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. Nat Neurosci (2014) 2.22
An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature (2016) 2.18
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
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Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev (2014) 1.59
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Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s). Genes Cancer (2010) 1.53
AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow. Cell Stem Cell (2015) 1.51
SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK). Cancer Biol Ther (2010) 1.49
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine (2015) 1.49
Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab (2014) 1.48
Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism. J Am Soc Nephrol (2015) 1.44
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biol Ther (2011) 1.43
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Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals: the role of SIRT1. Eur J Cancer Prev (2016) 1.39
Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics (2012) 1.38
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet (2010) 1.34
AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer. Cancer Res (2012) 1.31
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
Dietary and metabolic control of stem cell function in physiology and cancer. Cell Stem Cell (2014) 1.29
Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. Obstet Gynecol (2012) 1.29
Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein. Cell Rep (2014) 1.28
AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther (2013) 1.28
Metabolic alterations and targeted therapies in prostate cancer. J Pathol (2010) 1.28
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech (2010) 1.27
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A (2012) 1.26
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Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature (2012) 1.21
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell (2014) 1.21
Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist (2013) 1.20
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med (2014) 1.19
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2014) 1.17
BNip3 regulates mitochondrial function and lipid metabolism in the liver. Mol Cell Biol (2012) 1.17
AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell (2010) 1.16
LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol (2016) 1.15
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A (2014) 1.14
Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet. Hypertension (2012) 1.14
T cell metabolic fitness in antitumor immunity. Trends Immunol (2015) 1.12
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest (2013) 1.11
mTOR and metabolic pathways in T cell quiescence and functional activation. Semin Immunol (2013) 1.11
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Multifocal epithelial tumors and field cancerization: stroma as a primary determinant. J Clin Invest (2014) 1.10
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 1.10
Differential effects of AMPK agonists on cell growth and metabolism. Oncogene (2014) 1.09
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol (2015) 1.08
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol (2013) 1.08
Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells. BMC Cancer (2013) 1.07
Metabolic host responses to infection by intracellular bacterial pathogens. Front Cell Infect Microbiol (2013) 1.06
New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK. Clin Cancer Res (2010) 1.06
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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med (2007) 24.19
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med (2004) 13.57
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem (2009) 12.73
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 12.35
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature (2006) 12.13
Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer (2008) 11.50
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82
DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet (2001) 10.77
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature (2009) 10.59
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol (2009) 10.18
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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol (2009) 9.63
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol (2003) 9.14
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care (2006) 7.99
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
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The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab (2005) 7.15
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature (2005) 7.14
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res (2006) 6.99
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88
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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell (2005) 6.71
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab (2008) 6.60
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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10
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The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell (2004) 4.91
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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J (2007) 4.48
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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem (2007) 4.22
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell (2003) 4.13
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell (2004) 3.87
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
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Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell (2007) 3.49
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature (2003) 3.47
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol (2000) 3.28
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LKB1/STRAD promotes axon initiation during neuronal polarization. Cell (2007) 3.25
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
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Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science (2001) 2.99
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab (2009) 2.92
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell (2003) 2.88
Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun (2001) 2.86
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development (2000) 2.84
Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis. N Engl J Med (2008) 2.70
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PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat Cell Biol (2001) 2.69
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66
Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat Cell Biol (2007) 2.55
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell (2001) 2.53
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell (2013) 4.58
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab (2011) 3.98
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32
A hormone-dependent module regulating energy balance. Cell (2011) 2.30
mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A (2009) 2.08
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2012) 1.87
mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab (2013) 1.86
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy (2011) 1.85
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov (2013) 1.27
Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem (2009) 1.27
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One (2009) 1.25
Raptor is phosphorylated by cdc2 during mitosis. PLoS One (2010) 1.17
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem (2005) 1.15
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α. Proc Natl Acad Sci U S A (2014) 1.14
LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem (2010) 1.12
Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab (2012) 0.98
Genomics: Drugs, diabetes and cancer. Nature (2011) 0.94
Cancer metabolism: Tumour friend or foe. Nature (2012) 0.86
Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biol Rep (2012) 0.85
Cancer metabolism in breadth and depth. Nat Biotechnol (2013) 0.82
Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice. J Proteome Res (2015) 0.81
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Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2015) 0.75