Published in Cell Microbiol on July 31, 2006
Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. J Infect Dis (2008) 2.40
Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. Proc Natl Acad Sci U S A (2011) 2.13
A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins. PLoS Biol (2012) 2.08
Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS Pathog (2009) 2.02
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A (2011) 2.02
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii. PLoS Pathog (2007) 1.95
Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cell Microbiol (2010) 1.94
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses. Cell Host Microbe (2010) 1.90
Rhoptries: an arsenal of secreted virulence factors. Curr Opin Microbiol (2007) 1.65
Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol (2011) 1.53
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. EMBO J (2009) 1.50
Host cell manipulation by the human pathogen Toxoplasma gondii. Cell Mol Life Sci (2008) 1.49
A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuole. Traffic (2009) 1.46
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog (2012) 1.41
Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS (2009) 1.36
The Toxoplasma gondii dense granule protein GRA7 is phosphorylated upon invasion and forms an unexpected association with the rhoptry proteins ROP2 and ROP4. Infect Immun (2008) 1.31
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance. PLoS One (2012) 1.15
A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence. J Biol Chem (2011) 1.11
Intervacuolar transport and unique topology of GRA14, a novel dense granule protein in Toxoplasma gondii. Infect Immun (2008) 1.08
An overexpression screen of Toxoplasma gondii Rab-GTPases reveals distinct transport routes to the micronemes. PLoS Pathog (2013) 1.05
Protein kinases of Toxoplasma gondii: functions and drug targets. Parasitol Res (2013) 0.93
Toxoplasma rhoptries: unique secretory organelles and source of promising vaccine proteins for immunoprevention of toxoplasmosis. J Biomed Biotechnol (2008) 0.90
Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8. Int J Parasitol (2010) 0.89
Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. PLoS One (2012) 0.83
Apicoplast targeting of a Toxoplasma gondii transmembrane protein requires a cytosolic tyrosine-based motif. Traffic (2012) 0.81
Continuum approaches to understanding ion and peptide interactions with the membrane. J Membr Biol (2014) 0.80
The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells. PLoS Pathog (2016) 0.78
Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii. Korean J Parasitol (2016) 0.76
Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide. Science (2011) 2.32
Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS Pathog (2009) 2.02
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii. PLoS Pathog (2007) 1.95
The rhoptry neck protein RON4 re-localizes at the moving junction during Toxoplasma gondii invasion. Cell Microbiol (2005) 1.93
The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites. PLoS Pathog (2011) 1.84
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity. Structure (2009) 1.82
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Curr Biol (2009) 1.77
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling. Proteomics (2006) 1.64
The moving junction of apicomplexan parasites: a key structure for invasion. Cell Microbiol (2011) 1.54
Synergistic role of micronemal proteins in Toxoplasma gondii virulence. J Exp Med (2005) 1.48
Structural and functional insights into the malaria parasite moving junction complex. PLoS Pathog (2012) 1.44
Reliability of antimalarial sensitivity tests depends on drug mechanisms of action. J Clin Microbiol (2010) 1.43
The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO J (2002) 1.29
A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics (2008) 1.27
Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated. J Mol Biol (2005) 1.27
Heme binding contributes to antimalarial activity of bis-quaternary ammoniums. Antimicrob Agents Chemother (2003) 1.17
Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines. J Med Chem (2007) 1.14
Molecular signals in the trafficking of Toxoplasma gondii protein MIC3 to the micronemes. Eukaryot Cell (2008) 1.14
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PLoS One (2012) 1.09
The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell Microbiol (2013) 1.08
Apicomplexan cytoskeleton and motors: key regulators in morphogenesis, cell division, transport and motility. Int J Parasitol (2008) 1.06
Synthesis and antimalarial activity of trioxaquine derivatives. Chemistry (2004) 1.06
Characterization, biosynthesis and fate of ROP7, a ROP2 related rhoptry protein of Toxoplasma gondii. Mol Biochem Parasitol (2005) 1.05
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99
Targeting the Lipid Metabolic Pathways for the Treatment of Malaria. Drug Dev Res (2010) 0.98
Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target. PLoS One (2009) 0.98
Toxoplasma gondii Hsp20 is a stripe-arranged chaperone-like protein associated with the outer leaflet of the inner membrane complex. Biol Cell (2008) 0.98
Toxoplasma gondii has two lineages of histones 2b (H2B) with different expression profiles. Mol Biochem Parasitol (2006) 0.95
Mono- and bis-thiazolium salts have potent antimalarial activity. J Med Chem (2005) 0.92
Characterization of a non-mitochondrial type I phosphatidylserine decarboxylase in Plasmodium falciparum. Mol Microbiol (2004) 0.91
Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice. J Infect Dis (2006) 0.91
GRA12, a Toxoplasma dense granule protein associated with the intravacuolar membranous nanotubular network. Int J Parasitol (2008) 0.90
Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae. Antimicrob Agents Chemother (2004) 0.90
Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives. Bioorg Med Chem Lett (2006) 0.88
CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives. Malar J (2010) 0.88
Malaria Sporozoites Traverse Host Cells within Transient Vacuoles. Cell Host Microbe (2015) 0.87
Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy (2013) 0.87
Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic (2011) 0.87
Enhanced antimalarial activity of novel synthetic aculeatin derivatives. J Med Chem (2008) 0.87
Exploiting the therapeutic potential of Plasmodium falciparum solute transporters. Trends Parasitol (2010) 0.86
Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep. Vet Res (2010) 0.85
CRIMALDDI: platform technologies and novel anti-malarial drug targets. Malar J (2013) 0.85
Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol. Biochem J (2008) 0.85
Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases. Biochem J (2009) 0.85
Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res (2008) 0.84
Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. PLoS One (2012) 0.83
Food vacuole proteome of the malarial parasite Plasmodium falciparum. Proteomics Clin Appl (2008) 0.83
Malagashanine potentiates chloroquine antimalarial activity in drug resistant Plasmodium malaria by modifying both its efflux and influx. Mol Biochem Parasitol (2005) 0.83
Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates. Angew Chem Int Ed Engl (2014) 0.83
Choline analogues in malaria chemotherapy. Curr Pharm Des (2012) 0.83
Mic1-3KO tachyzoite a live attenuated vaccine candidate against toxoplasmosis derived from a type I strain shows features of type II strain. Exp Parasitol (2009) 0.83
Potential of beta-galactosidase-expressing Toxoplasma gondii for in situ localization and observation of rare stages of the parasite life cycle. Parasitol Res (2002) 0.83
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids. Malar J (2013) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues. ChemMedChem (2011) 0.80
Identification and characterization of Toxoplasma SIP, a conserved apicomplexan cytoskeleton protein involved in maintaining the shape, motility and virulence of the parasite. Cell Microbiol (2014) 0.80
Virulence factors of Toxoplasma gondii. Microbes Infect (2012) 0.80
Synthesis and antimalarial activity of new atovaquone derivatives. Eur J Med Chem (2009) 0.79
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials. Bioorg Med Chem Lett (2010) 0.79
Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies. Biochem J (2003) 0.79
Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies. Org Biomol Chem (2005) 0.79
Antiplasmodial properties of acyl-lysyl oligomers in culture and animal models of malaria. Antimicrob Agents Chemother (2011) 0.78
Synthesis and evaluation of bis-thiazolium salts as potential antimalarial drugs. ChemMedChem (2010) 0.78
Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides. J Org Chem (2013) 0.78
Design, synthesis and evaluation of new tricyclic endoperoxides as potential antiplasmodial agents. Org Biomol Chem (2014) 0.77
Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex. J Comput Aided Mol Des (2015) 0.77
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active. Biochem J (2013) 0.77
Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum. FEBS J (2013) 0.76
Forming spirocyclohexadienone-oxocarbenium cation species in the biomimetic synthesis of amomols. J Org Chem (2011) 0.76
Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs. Antimicrob Agents Chemother (2014) 0.76
Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs. ChemMedChem (2014) 0.76
Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs. ChemMedChem (2010) 0.75
Evaluation of bis-alkylamidoxime O-alkylsulfonates as orally available antimalarials. ChemMedChem (2012) 0.75
Antimalarial and anticancer activities of artemisinin-quinoline hybrid-dimers and pharmacokinetic properties in mice. Eur J Pharm Sci (2012) 0.75
Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives. Org Biomol Chem (2015) 0.75
Synthesis and antiplasmodial activity of streptocyanine/peroxide and streptocyanine/4-aminoquinoline hybrid dyes. Org Biomol Chem (2011) 0.75
Automated monitoring of phosphatidylcholine biosyntheses in Plasmodium falciparum by electrospray ionization mass spectrometry through stable isotope labeling experiments. Anal Chem (2004) 0.75
Corrigendum: Composite Aromatic Boxes for Enzymatic Transformations of Quaternary Ammonium Substrates. Angew Chem Int Ed Engl (2015) 0.75
Montpellier Infectious Diseases (MID), 2nd annual meeting (2012). Infect Genet Evol (2013) 0.75
Crucial role of the peroxyketal function for antimalarial activity in the G-factor series. Bioorg Med Chem Lett (2004) 0.75
Antimalarial bicyclic peroxides belonging to the G-factor family: mechanistic aspects of their formation and iron (II) induced reduction. Curr Top Med Chem (2014) 0.75
Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents. Bioorg Med Chem Lett (2008) 0.75
Synthesis and antimalarial properties of streptocyanine dyes. ChemMedChem (2009) 0.75
Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation. Bioorg Med Chem Lett (2010) 0.75
[Malaria: towards a new treatment!]. Med Sci (Paris) (2005) 0.75