Published in Structure on January 14, 2009
Protein kinases: evolution of dynamic regulatory proteins. Trends Biochem Sci (2010) 3.61
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe (2010) 2.57
Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol (2012) 2.18
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A (2011) 2.02
Pseudokinases-remnants of evolution or key allosteric regulators? Curr Opin Struct Biol (2010) 1.76
The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell (2009) 1.62
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. PLoS Biol (2009) 1.47
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18. PLoS Pathog (2012) 1.34
@TOME-2: a new pipeline for comparative modeling of protein-ligand complexes. Nucleic Acids Res (2009) 1.26
A conserved non-canonical motif in the pseudoactive site of the ROP5 pseudokinase domain mediates its effect on Toxoplasma virulence. J Biol Chem (2011) 1.11
Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum. PLoS Pathog (2009) 1.04
Pseudokinases: functional insights gleaned from structure. Structure (2009) 0.99
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase. J Biol Chem (2011) 0.99
Processing and secretion of ROP13: A unique Toxoplasma effector protein. Int J Parasitol (2010) 0.98
Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors. BMC Evol Biol (2013) 0.98
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii. Cell Microbiol (2012) 0.96
Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis. Eukaryot Cell (2009) 0.95
Protein kinases of Toxoplasma gondii: functions and drug targets. Parasitol Res (2013) 0.93
The secreted kinase ROP18 defends Toxoplasma's border. Bioessays (2011) 0.91
Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol (2011) 0.91
Association of host mitochondria with the parasitophorous vacuole during Toxoplasma infection is not dependent on rhoptry proteins ROP2/8. Int J Parasitol (2010) 0.89
Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem (2013) 0.87
The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases. J Biol Chem (2014) 0.85
Receptor tyrosine kinases with intracellular pseudokinase domains. Biochem Soc Trans (2013) 0.84
Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. PLoS One (2012) 0.83
Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach. PLoS One (2011) 0.83
A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle. Antimicrob Agents Chemother (2011) 0.82
Genomics, evolution, and crystal structure of a new family of bacterial spore kinases. Proteins (2010) 0.81
Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles. Eukaryot Cell (2015) 0.78
Nucleotide-binding mechanisms in pseudokinases. Biosci Rep (2015) 0.77
Electrophoretic Patterns of Toxoplasma gondii Excreted/Secreted Antigens and Their Role in Induction of the Humoral Immune Response. Jundishapur J Microbiol (2014) 0.77
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. PLoS One (2014) 0.77
STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure (2016) 0.75
Isolation and Proteomic Analysis of Rhoptry-Enriched Fractions from Cryptosporidium parvum. Iran J Public Health (2015) 0.75
Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division. PLoS Pathog (2017) 0.75
A landscape of driver mutations in melanoma. Cell (2012) 12.61
Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide. Science (2011) 2.32
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain. Structure (2003) 2.15
Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS Pathog (2009) 2.02
A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus. J Cell Sci (2006) 2.02
Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cells. Mol Biol Cell (2003) 1.98
ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii. PLoS Pathog (2007) 1.95
Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Cell Host Microbe (2008) 1.92
The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites. PLoS Pathog (2011) 1.84
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Curr Biol (2009) 1.77
Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. EMBO J (2010) 1.72
Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol (2012) 1.67
The ROP2 family of Toxoplasma gondii rhoptry proteins: proteomic and genomic characterization and molecular modeling. Proteomics (2006) 1.64
Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. Proc Natl Acad Sci U S A (2007) 1.60
The moving junction of apicomplexan parasites: a key structure for invasion. Cell Microbiol (2011) 1.54
Synergistic role of micronemal proteins in Toxoplasma gondii virulence. J Exp Med (2005) 1.48
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol (2013) 1.46
Structural and functional insights into the malaria parasite moving junction complex. PLoS Pathog (2012) 1.44
Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membrane. Cell Microbiol (2006) 1.44
Reliability of antimalarial sensitivity tests depends on drug mechanisms of action. J Clin Microbiol (2010) 1.43
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr D Biol Crystallogr (2011) 1.41
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A (2007) 1.34
The Toxoplasma gondii protein MIC3 requires pro-peptide cleavage and dimerization to function as adhesin. EMBO J (2002) 1.29
Inhibition of basal FGF receptor signaling by dimeric Grb2. Cell (2012) 1.28
Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins. Mol Biol Cell (2002) 1.28
GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin. Cell Signal (2007) 1.23
Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN. J Virol (2008) 1.23
Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proc Natl Acad Sci U S A (2014) 1.20
Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites. PLoS Pathog (2011) 1.19
Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells. EMBO J (2010) 1.18
Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. Eukaryot Cell (2010) 1.16
Molecular signals in the trafficking of Toxoplasma gondii protein MIC3 to the micronemes. Eukaryot Cell (2008) 1.14
Microcin E492 antibacterial activity: evidence for a TonB-dependent inner membrane permeabilization on Escherichia coli. Mol Microbiol (2003) 1.11
Roles of glycosylphosphatidylinositols of Toxoplasma gondii. Induction of tumor necrosis factor-alpha production in macrophages. J Biol Chem (2003) 1.11
A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos. Mol Microbiol (2011) 1.10
The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell Microbiol (2013) 1.08
Apicomplexan cytoskeleton and motors: key regulators in morphogenesis, cell division, transport and motility. Int J Parasitol (2008) 1.06
Characterization, biosynthesis and fate of ROP7, a ROP2 related rhoptry protein of Toxoplasma gondii. Mol Biochem Parasitol (2005) 1.05
Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins. J Biol Chem (2004) 1.03
Noise in cellular signaling pathways: causes and effects. Trends Biochem Sci (2012) 1.02
The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion. Cell Host Microbe (2013) 0.99
Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog (2011) 0.99
Antibacterial peptide pleurocidin forms ion channels in planar lipid bilayers. Biochim Biophys Acta (2002) 0.98
Toxoplasma gondii Hsp20 is a stripe-arranged chaperone-like protein associated with the outer leaflet of the inner membrane complex. Biol Cell (2008) 0.98
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother (2006) 0.96
Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses. Virol J (2009) 0.96
Intracellular pathway of Onconase that enables its delivery to the cytosol. J Cell Sci (2007) 0.95
FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J (2014) 0.93
Unique features of the folding landscape of a repeat protein revealed by pressure perturbation. Biophys J (2010) 0.93
Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems. J Am Chem Soc (2012) 0.93
Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells. Infect Immun (2005) 0.92
Direct interaction between the Rice yellow mottle virus (RYMV) VPg and the central domain of the rice eIF(iso)4G1 factor correlates with rice susceptibility and RYMV virulence. Mol Plant Microbe Interact (2010) 0.92
Subcellular localization and post-secretory targeting of TgPI, a serine proteinase inhibitor from Toxoplasma gondii. Mol Biochem Parasitol (2002) 0.91
Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice. J Infect Dis (2006) 0.91
Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole. Int J Parasitol (2007) 0.90
GRA12, a Toxoplasma dense granule protein associated with the intravacuolar membranous nanotubular network. Int J Parasitol (2008) 0.90
The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages. Mol Biochem Parasitol (2010) 0.89
Structural basis for the interaction between focal adhesion kinase and CD4. J Mol Biol (2007) 0.89
Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling. Methods Enzymol (2011) 0.88
Interaction of Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) with erythrocyte ankyrin R is required for its attachment to the erythrocyte membrane. Biochim Biophys Acta (2013) 0.88
Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii. Int J Parasitol (2002) 0.88
Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. J Mol Biol (2008) 0.88
Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS-like protein of Vibrio cholerae. J Mol Biol (2003) 0.88
Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase. Structure (2011) 0.87
Malaria Sporozoites Traverse Host Cells within Transient Vacuoles. Cell Host Microbe (2015) 0.87
Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy (2013) 0.87
Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic (2011) 0.87
How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs. Biochem J (2014) 0.86
PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest (2015) 0.86
Lipidomic analysis of Toxoplasma gondii tachyzoites rhoptries: further insights into the role of cholesterol. Biochem J (2008) 0.85
Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases. Biochem J (2009) 0.85
Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep. Vet Res (2010) 0.85
Monoclonal antibodies specific for the two types of wall-forming bodies of Eimeria tenella macrogametes (Coccidia, Apicomplexa). Parasitol Res (2002) 0.84
Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J Lipid Res (2008) 0.84
Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole. Traffic (2008) 0.84
Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. PLoS One (2012) 0.83
Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates. Angew Chem Int Ed Engl (2014) 0.83
Mic1-3KO tachyzoite a live attenuated vaccine candidate against toxoplasmosis derived from a type I strain shows features of type II strain. Exp Parasitol (2009) 0.83
Food vacuole proteome of the malarial parasite Plasmodium falciparum. Proteomics Clin Appl (2008) 0.83
Solution structure of the tandem acyl carrier protein domains from a polyunsaturated fatty acid synthase reveals beads-on-a-string configuration. PLoS One (2013) 0.82
First evidence of the pore-forming properties of a keratin from skin mucus of rainbow trout (Oncorhynchus mykiss, formerly Salmo gairdneri). Biochem J (2008) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
A specific protein disorder catalyzer of HIV-1 Nef. Bioorg Med Chem (2011) 0.81
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X. Biochem J (2010) 0.81