Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMC 1567696)

Published in Proc Natl Acad Sci U S A on August 01, 2006

Authors

Sabine Seitz1, Christian K Schneider, Joachim Malotka, Xiao Nong, Andrew G Engel, Hartmut Wekerle, Reinhard Hohlfeld, Klaus Dornmair

Author Affiliations

1: Institute for Clinical Neuroimmunology, Ludwig Maximilians University, D-81377 Munich, Germany.

Articles citing this

Melanocyte antigen triggers autoimmunity in human psoriasis. J Exp Med (2015) 2.11

High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med (2013) 1.40

Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes. Br J Cancer (2009) 1.25

Sequence analysis of T-cell repertoires in health and disease. Genome Med (2013) 1.17

Analysis of the paired TCR α- and β-chains of single human T cells. PLoS One (2012) 1.14

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun (2010) 1.10

Amplification of multiple genomic loci from single cells isolated by laser micro-dissection of tissues. BMC Biotechnol (2008) 1.09

Pathogenic CD8 T cells in multiple sclerosis and its experimental models. Front Immunol (2012) 1.01

Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models. Biochim Biophys Acta (2010) 1.00

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides. Nat Med (2012) 0.97

αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm (2015) 0.88

Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis. J Biol Chem (2012) 0.88

Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis. Ann Clin Transl Neurol (2015) 0.86

Inclusion body myositis: laser microdissection reveals differential up-regulation of IFN-γ signaling cascade in attacked versus nonattacked myofibers. Am J Pathol (2011) 0.84

Novel approaches for identifying target antigens of autoreactive human B and T cells. Semin Immunopathol (2009) 0.83

Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes. Diabetes Metab Res Rev (2010) 0.82

CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing. Nat Commun (2016) 0.81

Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions. Clin Exp Immunol (2008) 0.77

Identification and isolation of antigen-specific cytotoxic T lymphocytes with an automated microraft sorting system. Integr Biol (Camb) (2016) 0.75

Stromal and intraepithelial tumor-infiltrating lymphocytes in colorectal carcinoma. Oncol Lett (2017) 0.75

Articles cited by this

A direct estimate of the human alphabeta T cell receptor diversity. Science (1999) 6.85

The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity (2001) 4.72

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85

T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol (2004) 3.85

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med (2000) 3.84

T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today (1995) 3.60

Expression of two T cell receptor alpha chains: dual receptor T cells. Science (1993) 3.54

How T cells 'see' antigen. Nat Immunol (2005) 2.87

Human T-cell receptor variable gene segment families. Immunogenetics (1995) 2.86

Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibers invaded by T cells. Ann Neurol (1984) 2.66

The cognitive paradigm and the immunological homunculus. Immunol Today (1992) 2.33

Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J Immunol (1994) 2.21

Polymyositis mediated by T lymphocytes that express the gamma/delta receptor. N Engl J Med (1991) 2.00

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A (2004) 1.80

Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol (2001) 1.70

Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc Natl Acad Sci U S A (2002) 1.49

Monoclonal antibody analysis of mononuclear cells in myopathies. II: Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol (1984) 1.43

Mechanisms of disease: signaling pathways and immunobiology of inflammatory myopathies. Nat Clin Pract Rheumatol (2006) 1.36

Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. J Clin Invest (1996) 1.24

Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. J Clin Invest (1993) 1.23

Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proc Natl Acad Sci U S A (2003) 1.07

Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma. Eur J Immunol (1993) 1.07

T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells. J Exp Med (1995) 1.04

Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal. Eur J Immunol (1998) 1.02

Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma/delta T cell receptor. J Exp Med (1992) 1.01

Diversity of T cell receptor alpha and beta chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. Eur J Immunol (1992) 0.97

Oligoclonality of CD8+ T cells in multiple sclerosis. Autoimmunity (1996) 0.97

Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity (2005) 0.97

T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med (2003) 0.90

Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year. J Exp Med (2003) 0.89

Clonal biases of peripheral CD8 T cell repertoire directly reflect local inflammation in polymyositis. J Immunol (2001) 0.87

An autoreactive gamma delta TCR derived from a polymyositis lesion. J Immunol (2002) 0.86

Reconstitution of CD8+ T cells by retroviral transfer of the TCR alpha beta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte. J Immunol (2003) 0.84

T-cell heterogeneity in muscle lesions of inclusion body myositis. J Neuroimmunol (1998) 0.82

Immunology: insulin trigger for diabetes. Nature (2005) 0.81

Antigen recognition properties of a Vgamma1.3Vdelta2-T-cell receptor from a rare variant of polymyositis. J Neuroimmunol (2004) 0.80

Paired cloning of the T cell receptor alpha and beta genes from a single T cell without the establishment of a T cell clone. Clin Exp Immunol (2001) 0.79

Understanding the immunopathogenesis of inclusion-body myositis: present and future prospects. Rev Neurol (Paris) (2002) 0.78

Articles by these authors

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med (2010) 13.70

Polymyositis and dermatomyositis. Lancet (2003) 7.24

Recent advances in Cys-loop receptor structure and function. Nature (2006) 4.20

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature (2011) 4.07

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature (2009) 3.33

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain (2009) 2.74

Clinical development of advanced therapy medicinal products in Europe: evidence that regulators must be proactive. Mol Ther (2012) 2.68

Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J Exp Med (2005) 2.54

B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann Neurol (2006) 2.52

T cells become licensed in the lung to enter the central nervous system. Nature (2012) 2.45

Mutations in myotilin cause myofibrillar myopathy. Neurology (2004) 2.41

Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol (2008) 2.40

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J Clin Invest (2006) 2.32

Biosimilars: what clinicians should know. Blood (2012) 2.28

Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet Neurol (2011) 2.19

Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain (2005) 2.17

Correlation of muscle biopsy, clinical course, and outcome in PM and sporadic IBM. Neurology (2007) 2.14

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med (2009) 2.13

Challenges with advanced therapy medicinal products and how to meet them. Nat Rev Drug Discov (2010) 2.09

Neurofascin as a target for autoantibodies in peripheral neuropathies. Neurology (2012) 2.09

Electromyographic findings in 37 patients with adult-onset acid maltase deficiency. Muscle Nerve (2015) 2.07

Biosimilars in rheumatology: the wind of change. Ann Rheum Dis (2013) 2.03

Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann Neurol (2009) 2.03

Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: implications for multiple sclerosis therapy. Brain-derived neurotrophic factor. Brain (2002) 2.02

Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain (2007) 1.94

BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J Exp Med (2005) 1.92

The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med (2004) 1.90

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. J Exp Med (2013) 1.88

Mutations in ZASP define a novel form of muscular dystrophy in humans. Ann Neurol (2005) 1.80

Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc Natl Acad Sci U S A (2004) 1.80

Myofibrillar myopathy: clinical, morphological and genetic studies in 63 patients. Brain (2004) 1.80

B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol (2012) 1.80

Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med (2007) 1.77

Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations. Ann Neurol (2003) 1.77

Biosimilars-why terminology matters. Nat Biotechnol (2011) 1.73

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One (2010) 1.73

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat Med (2008) 1.72

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism. J Neurosci (2002) 1.64

Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells. Brain Pathol (2010) 1.61

Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome. Am J Hum Genet (2002) 1.61

Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med (2007) 1.61

Bridging the efficacy-effectiveness gap: a regulator's perspective on addressing variability of drug response. Nat Rev Drug Discov (2011) 1.58

The risks of risk aversion in drug regulation. Nat Rev Drug Discov (2013) 1.55

Are MuSK antibodies the primary cause of myasthenic symptoms? Neurology (2004) 1.54

Delayed allergic reaction to natalizumab associated with early formation of neutralizing antibodies. Arch Neurol (2007) 1.52

Myasthenic syndrome caused by mutation of the SCN4A sodium channel. Proc Natl Acad Sci U S A (2003) 1.50

Sporadic centronuclear myopathy with muscle pseudohypertrophy, neutropenia, and necklace fibers due to a DNM2 mutation. Neuromuscul Disord (2010) 1.50

Highly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding site. Neurology (2012) 1.49

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci U S A (2004) 1.49

Phenotypic heterogeneity in a large Thai slow-channel congenital myasthenic syndrome kinship. Neuromuscul Disord (2011) 1.41

Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue. Arch Neurol (2009) 1.40

Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating. J Clin Invest (2003) 1.36

De-escalation from natalizumab in multiple sclerosis: recurrence of disease activity despite switching to glatiramer acetate. J Neurol (2011) 1.35

126th International Workshop: congenital myasthenic syndromes, 24-26 September 2004, Naarden, the Netherlands. Neuromuscul Disord (2005) 1.35

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med (2009) 1.34

CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain (2009) 1.33

BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain (2002) 1.33

In support of the European Union biosimilar framework. Nat Biotechnol (2012) 1.33

Sporadic late onset nemaline myopathy. Neurology (2005) 1.32

Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo. Brain (2004) 1.32

Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines. Int Immunol (2004) 1.31

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proc Natl Acad Sci U S A (2009) 1.30

Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. J Immunol (2013) 1.27

Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints. Cytotherapy (2013) 1.27

Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A (2009) 1.27

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol (2011) 1.27

Impact of fingolimod therapy on magnetic resonance imaging outcomes in patients with multiple sclerosis. Arch Neurol (2012) 1.27

Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad Sci U S A (2009) 1.26

Immunobiology of muscle: advances in understanding an immunological microenvironment. Trends Immunol (2005) 1.23

Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating. J Gen Physiol (2002) 1.23

Late-onset tumor necrosis factor receptor-associated periodic syndrome in multiple sclerosis patients carrying the TNFRSF1A R92Q mutation. Arthritis Rheum (2007) 1.19

Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs (2002) 1.16

The human adult subtype ACh receptor channel has high Ca2+ permeability and predisposes to endplate Ca2+ overloading. J Physiol (2006) 1.16

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med (2012) 1.15

The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci U S A (2008) 1.15

Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann Neurol (2003) 1.15

Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action. CNS Drugs (2011) 1.15

Analysis of the paired TCR α- and β-chains of single human T cells. PLoS One (2012) 1.14

Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2007) 1.13