Published in J Cell Physiol on November 01, 2006
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One (2008) 2.47
New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03
Local translation of extranuclear lamin B promotes axon maintenance. Cell (2012) 1.79
The molecular mechanism and cellular functions of mitochondrial division. Biochim Biophys Acta (2008) 1.67
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol (2009) 1.61
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem (2010) 1.56
Mitochondrial morphology and cardiovascular disease. Cardiovasc Res (2010) 1.51
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci (2010) 1.47
The intracellular redox state is a core determinant of mitochondrial fusion. EMBO Rep (2012) 1.40
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol (2013) 1.38
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. Chem Biol (2010) 1.30
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci (2012) 1.30
Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22
Mitochondrial dynamics in cardiovascular health and disease. Antioxid Redox Signal (2012) 1.17
Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J (2009) 1.15
The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading. J Physiol (2015) 1.12
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. Aging Cell (2014) 1.11
75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes. Arthritis Rheum (2012) 1.09
Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J Biol Chem (2012) 1.08
Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Hum Mol Genet (2011) 1.06
Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy (2011) 1.06
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem (2013) 1.04
Mitochondrial death pathways in yeast and mammalian cells. Biochim Biophys Acta (2008) 1.04
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ (2008) 1.04
C. elegans ATAD-3 is essential for mitochondrial activity and development. PLoS One (2009) 0.98
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev (2014) 0.98
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J Biol Chem (2010) 0.96
Mitochondrial dynamics and motility inside living vascular endothelial cells: role of bioenergetics. Ann Biomed Eng (2012) 0.92
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One (2013) 0.92
Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis. Cell Rep (2013) 0.91
Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction. J Biol Chem (2013) 0.86
Air pollution particulate matter alters antimycobacterial respiratory epithelium innate immunity. Infect Immun (2015) 0.84
The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection. Front Immunol (2014) 0.84
Influence of age on rat bone-marrow mesenchymal stem cells potential. Sci Rep (2015) 0.83
Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. Endocrinol Metab (Seoul) (2013) 0.83
miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor. Exp Mol Med (2014) 0.82
Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed hepatoma cell growth. Mol Cells (2013) 0.82
Reversal of phenotypes of cellular senescence by pan-mTOR inhibition. Aging (Albany NY) (2016) 0.80
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats. Oncotarget (2015) 0.78
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. PLoS One (2016) 0.77
Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress. Oxid Med Cell Longev (2016) 0.77
The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res (2016) 0.77
Do we age because we have mitochondria? Protoplasma (2013) 0.77
Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells. PLoS One (2014) 0.77
Mitochondrial elongation in the macular RPE of aging monkeys, evidence of metabolic stress. Graefes Arch Clin Exp Ophthalmol (2016) 0.76
The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxid Med Cell Longev (2016) 0.76
Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology (2014) 0.76
ER fatalities-The role of ER-mitochondrial contact sites in yeast life and death decisions. Mech Ageing Dev (2016) 0.75
Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis. J Biol Chem (2016) 0.75
Resveratrol modulates mitochondria dynamics in replicative senescent yeast cells. PLoS One (2014) 0.75
Proteomic profiling of mitochondria: what does it tell us about the ageing brain? Aging (Albany NY) (2016) 0.75
Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle. J Physiol (2016) 0.75
Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD. Int J Biochem Cell Biol (2016) 0.75
Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function. Oncotarget (2016) 0.75
T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor. Cell Death Differ (2016) 0.75
Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxid Med Cell Longev (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell (2002) 4.48
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem (2003) 3.84
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77
SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J (2009) 3.61
Identification and functional expression of the mitochondrial pyruvate carrier. Science (2012) 3.15
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell (2010) 2.96
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol (2006) 2.71
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol (2009) 2.65
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One (2008) 2.47
Organization and dynamics of human mitochondrial DNA. J Cell Sci (2004) 2.45
Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev Cell (2009) 2.33
Separate fusion of outer and inner mitochondrial membranes. EMBO Rep (2005) 1.93
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol (2002) 1.90
Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem (2003) 1.86
Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J Biol Chem (2004) 1.84
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J (2004) 1.77
Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science (2009) 1.75
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem (2011) 1.74
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J (2002) 1.71
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab (2013) 1.57
Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene (2005) 1.57
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. Hepatology (2010) 1.56
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50
An anti-apoptotic viral protein that recruits Bax to mitochondria. J Biol Chem (2004) 1.49
Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A. Exp Neurol (2009) 1.47
Oxidative stress caused by mitochondrial calcium overload. Ann N Y Acad Sci (2010) 1.46
Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene (2004) 1.41
The apoptotic protein tBid promotes leakage by altering membrane curvature. J Biol Chem (2002) 1.40
[Mitochondrial morphology and dynamics: actors, mechanisms and functions]. Med Sci (Paris) (2010) 1.39
TGF beta1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells. Oncogene (2005) 1.38
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem (2005) 1.37
The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep (2010) 1.36
Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. Biol Cell (2008) 1.33
Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J Biol Chem (2003) 1.31
Mitochondrial dynamics and cancer. Semin Cancer Biol (2008) 1.29
Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mech Ageing Dev (2008) 1.29
Involvement of p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1beta-induced matrix metalloproteinase-9 expression in rat brain astrocytes. J Neurochem (2004) 1.29
A comparative analysis of the cell biology of senescence and aging. Cell Mol Life Sci (2009) 1.26
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Direct evidence for membrane pore formation by the apoptotic protein Bax. Biochem Biophys Res Commun (2002) 1.20
Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta (2011) 1.19
Wnt/Snail signaling regulates cytochrome C oxidase and glucose metabolism. Cancer Res (2012) 1.19
Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. Int J Biochem Cell Biol (2009) 1.17
Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Infect Immun (2002) 1.15
Newcomers in the process of mitochondrial permeabilization. J Cell Sci (2005) 1.15
Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis. Ann N Y Acad Sci (2005) 1.15
SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability. Biochim Biophys Acta (2008) 1.14
Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics. Semin Cell Dev Biol (2009) 1.13
Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes. J Neuroinflammation (2012) 1.11
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res (2009) 1.11
In-vitro and in-vivo anti-inflammatory effect of oxyresveratrol from Morus alba L. J Pharm Pharmacol (2003) 1.09
Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics (2012) 1.09
Mitochondrial dynamics and apoptosis: a painful separation. Dev Cell (2008) 1.08
Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells. J Biol Chem (2009) 1.07
Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy (2011) 1.06
Oxidation-reduction respiratory chains and ATP synthase complex are localized in detergent-resistant lipid rafts. Proteomics (2006) 1.06
Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1. Cell Signal (2004) 1.04
Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis. Cold Spring Harb Perspect Biol (2013) 1.03
Outer membrane protein A of Acinetobacter baumannii induces differentiation of CD4+ T cells toward a Th1 polarizing phenotype through the activation of dendritic cells. Biochem Pharmacol (2007) 1.03
Temporal dissection of Bax-induced events leading to fission of the single mitochondrion in Trypanosoma brucei. EMBO Rep (2004) 1.02
Mitochondrial dynamics: to be in good shape to survive. Curr Mol Med (2008) 1.01
Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell (2008) 1.00
Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production. J Cell Biochem (2008) 1.00
Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. J Biol Chem (2004) 0.99
TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1-Forkhead box M1 regulation loop. Hepatology (2008) 0.98
Organization, dynamics and transmission of mitochondrial DNA: focus on vertebrate nucleoids. Biochim Biophys Acta (2006) 0.98
Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. J Biol Chem (2005) 0.98
Mitochondrial fission and apoptosis: an ongoing trial. Biochim Biophys Acta (2006) 0.97
Anti-obesity and hypolipidemic effects of black soybean anthocyanins. J Med Food (2007) 0.97
Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells. Free Radic Biol Med (2009) 0.97
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J Biol Chem (2010) 0.96
Bid induces cytochrome c-impermeable Bax channels in liposomes. Biochem J (2002) 0.96
Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. Exp Cell Res (2011) 0.95
Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. Brain (2010) 0.95
Direct activation of TGF-beta1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude mice. J Cell Biochem (2006) 0.95
Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane. Expert Rev Proteomics (2010) 0.94
TIS21/BTG2/PC3 is expressed through PKC-delta pathway and inhibits binding of cyclin B1-Cdc2 and its activity, independent of p53 expression. Exp Cell Res (2004) 0.94
Transbilayer lipid diffusion promoted by Bax: implications for apoptosis. Biochemistry (2003) 0.94
Common mutations in Cuban cystic fibrosis patients. J Cyst Fibros (2008) 0.94
Implications of time-series gene expression profiles of replicative senescence. Aging Cell (2013) 0.92
Complex II defect via down-regulation of iron-sulfur subunit induces mitochondrial dysfunction and cell cycle delay in iron chelation-induced senescence-associated growth arrest. J Biol Chem (2003) 0.92
BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Cell Signal (2006) 0.92
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells. Cell Signal (2013) 0.90
Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. C R Biol (2005) 0.90
Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress. Biochim Biophys Acta (2005) 0.90
Melatonin combats molecular terrorism at the mitochondrial level. Interdiscip Toxicol (2008) 0.90
Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. FASEB J (2011) 0.89
TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis. Apoptosis (2013) 0.89
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer. Biochem J (2005) 0.89