Published in J Biol Chem on June 03, 2003
The BCL-2 family reunion. Mol Cell (2010) 7.32
Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol (2010) 6.58
Mitochondrial dynamics and apoptosis. Genes Dev (2008) 6.07
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell (2004) 5.94
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A (2004) 5.34
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell (2011) 4.91
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci (2008) 4.32
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death. J Cell Biol (2007) 3.61
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2008) 3.57
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol (2004) 3.55
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol (2009) 3.49
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J (2011) 2.71
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol (2006) 2.71
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol (2009) 2.65
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Natl Acad Sci U S A (2007) 2.65
A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J (2006) 2.52
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network: new implications for Charcot-Marie-Tooth disease. J Cell Biol (2005) 2.32
Mitochondrial fission proteins regulate programmed cell death in yeast. Genes Dev (2004) 2.30
Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol (2004) 2.28
Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol (2010) 2.27
Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J (2009) 2.11
Energetics, epigenetics, mitochondrial genetics. Mitochondrion (2009) 2.08
An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J (2010) 2.01
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons. J Cell Biol (2009) 1.97
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2005) 1.89
The pathophysiology of mitochondrial disease as modeled in the mouse. Genes Dev (2009) 1.87
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest (2013) 1.83
Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes (2009) 1.81
The molecular mechanism and cellular functions of mitochondrial division. Biochim Biophys Acta (2008) 1.67
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med (2012) 1.67
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease. J Neurochem (2009) 1.67
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell (2008) 1.61
Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J (2010) 1.57
Mitochondrial morphology and cardiovascular disease. Cardiovasc Res (2010) 1.51
Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol (2009) 1.51
Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta (2009) 1.49
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo. Mol Biol Cell (2010) 1.49
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane. Mol Biol Cell (2008) 1.48
Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48
Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch (2007) 1.47
Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int (2013) 1.46
Mitochondrial dynamics in diabetes. Antioxid Redox Signal (2010) 1.46
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol (2012) 1.44
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci (2012) 1.42
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell (2011) 1.39
The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. J Cell Biol (2005) 1.33
Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ (2010) 1.31
Drp1 mediates caspase-independent type III cell death in normal and leukemic cells. Mol Cell Biol (2007) 1.29
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines. Proc Natl Acad Sci U S A (2008) 1.28
Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. J Biol Chem (2007) 1.28
Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia (2009) 1.27
Mitochondrial dysfunction in amyotrophic lateral sclerosis. Biochim Biophys Acta (2009) 1.27
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk and cardiomyocyte fate. Circ Res (2010) 1.24
Mitochondrial division: molecular machinery and physiological functions. Curr Opin Cell Biol (2011) 1.22
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem (2013) 1.19
The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse. EMBO J (2011) 1.19
Muscle oxidative capacity during IL-6-dependent cancer cachexia. Am J Physiol Regul Integr Comp Physiol (2010) 1.19
Mitochondrial dynamics in cardiovascular health and disease. Antioxid Redox Signal (2012) 1.17
Viruses activate a genetically conserved cell death pathway in a unicellular organism. J Cell Biol (2005) 1.15
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission. J Cell Biol (2014) 1.15
miR-484 regulates mitochondrial network through targeting Fis1. Nat Commun (2012) 1.14
Shaping the role of mitochondria in the pathogenesis of Huntington's disease. EMBO J (2012) 1.11
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. Exp Neurol (2009) 1.11
Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells. PLoS One (2009) 1.09
Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci U S A (2011) 1.08
Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol (2010) 1.07
Alzheimer's disease: diverse aspects of mitochondrial malfunctioning. Int J Clin Exp Pathol (2010) 1.07
Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta (2010) 1.07
The role of mitochondria in neurodegenerative diseases. J Neurol (2011) 1.05
Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria. J Inherit Metab Dis (2008) 1.05
Cell signaling and mitochondrial dynamics: Implications for neuronal function and neurodegenerative disease. Neurobiol Dis (2012) 1.05
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol (2012) 1.05
Mitochondrial death pathways in yeast and mammalian cells. Biochim Biophys Acta (2008) 1.04
Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects. Cell Death Differ (2008) 1.04
IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse. Skelet Muscle (2012) 1.02
IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ (2013) 1.02
New insights into mitochondrial structure during cell death. Exp Neurol (2009) 1.01
Mitochondrial dynamics: functional link with apoptosis. Int J Cell Biol (2012) 0.99
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J Alzheimers Dis (2010) 0.98
Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol Biol Cell (2013) 0.98
Mitochondrial morphology in metabolic diseases. Antioxid Redox Signal (2012) 0.98
Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98
Mitochondrial dynamics in heart failure. Congest Heart Fail (2012) 0.98
Discovery of the membrane receptor for mitochondrial fission GTPase Drp1. Small GTPases (2011) 0.97
Hyperglycemia alters mitochondrial fission and fusion proteins in mice subjected to cerebral ischemia and reperfusion. Transl Stroke Res (2012) 0.97
CED-9 and mitochondrial homeostasis in C. elegans muscle. J Cell Sci (2008) 0.97
WD40 protein Mda1 is purified with Dnm1 and forms a dividing ring for mitochondria before Dnm1 in Cyanidioschyzon merolae. Proc Natl Acad Sci U S A (2007) 0.96
Targeting of hFis1 to peroxisomes is mediated by Pex19p. J Biol Chem (2008) 0.95
Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies. Drugs Aging (2010) 0.95
Mitochondrial quality control pathways as determinants of metabolic health. Bioessays (2015) 0.95
Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates. Cell Mol Life Sci (2012) 0.93
The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Exp Cell Res (2008) 0.93
In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts. Biochim Biophys Acta (2013) 0.92
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Mol Neurobiol (2010) 0.92
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J (2009) 3.61
Identification and functional expression of the mitochondrial pyruvate carrier. Science (2012) 3.15
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell (2010) 2.96
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis. Mol Cell Biol (2006) 2.71
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J Cell Biol (2009) 2.65
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell (2011) 2.52
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One (2008) 2.47
Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev Cell (2009) 2.33
Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol (2006) 1.96
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol (2002) 1.90
Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem (2003) 1.86
Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1. J Biol Chem (2004) 1.84
Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science (2009) 1.75
Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J (2002) 1.71
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell Metab (2013) 1.57
An anti-apoptotic viral protein that recruits Bax to mitochondria. J Biol Chem (2004) 1.49
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48
Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A. Exp Neurol (2009) 1.47
Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene (2004) 1.41
The apoptotic protein tBid promotes leakage by altering membrane curvature. J Biol Chem (2002) 1.40
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem (2005) 1.37
Mitochondrial dynamics and cancer. Semin Cancer Biol (2008) 1.29
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells. J Biol Chem (2008) 1.25
Direct evidence for membrane pore formation by the apoptotic protein Bax. Biochem Biophys Res Commun (2002) 1.20
Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission. Biochim Biophys Acta (2011) 1.19
Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. Int J Biochem Cell Biol (2009) 1.17
Role of Bcl-2 family members in caspase-independent apoptosis during Chlamydia infection. Infect Immun (2002) 1.15
Newcomers in the process of mitochondrial permeabilization. J Cell Sci (2005) 1.15
SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability. Biochim Biophys Acta (2008) 1.14
Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics (2012) 1.09
Mitochondrial dynamics and apoptosis: a painful separation. Dev Cell (2008) 1.08
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage. Biol Direct (2009) 1.07
Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis. Cold Spring Harb Perspect Biol (2013) 1.03
Temporal dissection of Bax-induced events leading to fission of the single mitochondrion in Trypanosoma brucei. EMBO Rep (2004) 1.02
Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem (2013) 1.02
Mitochondrial dynamics: to be in good shape to survive. Curr Mol Med (2008) 1.01
Bax does not directly participate in the Ca(2+)-induced permeability transition of isolated mitochondria. J Biol Chem (2004) 0.99
Mitochondrial fission and apoptosis: an ongoing trial. Biochim Biophys Acta (2006) 0.97
Bid induces cytochrome c-impermeable Bax channels in liposomes. Biochem J (2002) 0.96
Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. Brain (2010) 0.95
Transbilayer lipid diffusion promoted by Bax: implications for apoptosis. Biochemistry (2003) 0.94
Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane. C R Biol (2005) 0.90
Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. FASEB J (2011) 0.89
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer. Biochem J (2005) 0.89
TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis. Apoptosis (2013) 0.89
Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett (2002) 0.86
Purification and proteomic analysis of the mouse liver mitochondrial inner membrane. Methods Mol Biol (2008) 0.86
Membrane perturbations induced by the apoptotic Bax protein. Biochem J (2002) 0.84
The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. FEBS Lett (2005) 0.81
Fatty acids enhance membrane permeabilization by pro-apoptotic Bax. Biochem J (2004) 0.81
SLP-2 negatively modulates mitochondrial sodium-calcium exchange. Cell Calcium (2009) 0.81
Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium. Cancer Biol Ther (2012) 0.80
A retention factor keeps death at bay. Nat Cell Biol (2003) 0.80
Building the mitochondrial proteome. Expert Rev Proteomics (2005) 0.80
Preprotein transport machineries of yeast mitochondrial outer membrane are not required for Bax-induced release of intermembrane space proteins. J Mol Biol (2007) 0.80
Apoptosis: bombarding the mitochondria. Essays Biochem (2003) 0.80
Life without the mitochondrial calcium uniporter. Nat Cell Biol (2013) 0.79
TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak. Apoptosis (2014) 0.79
Mechanisms of mitochondrial outer membrane permeabilization. Novartis Found Symp (2007) 0.79
Autophagy: evolutionary and pathophysiological insights. Biochim Biophys Acta (2009) 0.78
Targeting the retinoblastoma protein by MC007L, gene product of the molluscum contagiosum virus: detection of a novel virus-cell interaction by a member of the poxviruses. J Virol (2008) 0.76
Granzyme a, a stealth killer in the mitochondrion. Cell (2008) 0.75
[Mitochondrial dynamics: from geometry to function]. Med Sci (Paris) (2010) 0.75
Mitochondrial dynamics: quantifying mitochondrial fusion in vitro. BMC Biol (2010) 0.75
[Changes in the outer mitochondrial membranes during apoptosis]. J Soc Biol (2005) 0.75