Published in Sci STKE on August 01, 2006
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol (2008) 2.76
Assessing the potential of glucokinase activators in diabetes therapy. Nat Rev Drug Discov (2009) 2.60
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
A two-way street: reciprocal regulation of metabolism and signalling. Nat Rev Mol Cell Biol (2012) 2.35
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity. Proc Natl Acad Sci U S A (2010) 1.86
Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity (Silver Spring) (2008) 1.71
Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. J Biol Chem (2012) 1.63
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest (2012) 1.35
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Mol Cell (2014) 1.28
O-GlcNAc cycling: implications for neurodegenerative disorders. Int J Biochem Cell Biol (2009) 1.22
Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons. PLoS Biol (2008) 1.21
Central carbon metabolism in the progression of mammary carcinoma. Breast Cancer Res Treat (2007) 1.16
Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway. J Physiol (2006) 1.15
Down-regulation of honey bee IRS gene biases behavior toward food rich in protein. PLoS Genet (2010) 1.14
Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver. J Cell Commun Signal (2007) 1.13
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest (2013) 1.11
PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A (2007) 1.09
Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance. Am J Physiol Endocrinol Metab (2009) 1.08
Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3). J Cell Biochem (2010) 1.07
Carbon and nitrogen nutrient balance signaling in plants. Plant Signal Behav (2009) 1.01
Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. J Endocrinol (2009) 1.00
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem (2015) 0.97
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One (2010) 0.97
Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. Gastroenterology (2013) 0.97
A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome. J Cell Sci (2011) 0.96
TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity. PLoS One (2012) 0.94
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chem Biol (2010) 0.94
Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. J Biol Chem (2010) 0.94
Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. Cell Rep (2015) 0.91
The OSU1/QUA2/TSD2-encoded putative methyltransferase is a critical modulator of carbon and nitrogen nutrient balance response in Arabidopsis. PLoS One (2008) 0.91
Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Dis Model Mech (2013) 0.91
Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer. Cancer (2010) 0.88
Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci (2013) 0.87
Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT). PLoS One (2012) 0.84
Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction. Elife (2015) 0.83
TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway. Diabetes (2013) 0.83
miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity. Sci Rep (2016) 0.82
Effect of walking exercise on abdominal fat, insulin resistance and serum cytokines in obese women. J Exerc Nutrition Biochem (2014) 0.81
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. Mol Endocrinol (2009) 0.81
Glucose metabolism gene variants modulate the risk of pancreatic cancer. Cancer Prev Res (Phila) (2011) 0.81
Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles. Mol Cell Biol (2012) 0.80
Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin? Curr Breast Cancer Rep (2011) 0.79
O-GlcNAc Modification: Friend or Foe in Diabetic Cardiovascular Disease. Korean Diabetes J (2010) 0.79
Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep. J Nutr Biochem (2010) 0.78
Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity-An Overview. Foods (2013) 0.76
Roles of physical activity and cardiorespiratory fitness on sex difference in insulin resistance in late elementary years. J Exerc Nutrition Biochem (2014) 0.76
Metformin- A Promising Agent for Chemoprevention in BRCA1 Carriers. Hereditary Genet (2012) 0.75
The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver. Prev Nutr Food Sci (2015) 0.75
High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster. Oxid Med Cell Longev (2016) 0.75
Obesity, Diabetes and Cancer: A Mechanistic Perspective. Int J Diabetol Vasc Dis Res (2015) 0.75
Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model. BMC Complement Altern Med (2015) 0.75
Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet-Induced Insulin Resistance. Diabetes (2016) 0.75
Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage. Int J Rheumatol (2016) 0.75
Early detection of metabolic and energy disorders by thermal time series stochastic complexity analysis. Braz J Med Biol Res (2014) 0.75
Achieving global perfect homeostasis through transporter regulation. PLoS Comput Biol (2017) 0.75
Identification, expression and variation of the GNPDA2 gene, and its association with body weight and fatness traits in chicken. PeerJ (2016) 0.75