Non-human primate fetal kidney transcriptome analysis indicates mammalian target of rapamycin (mTOR) is a central nutrient-responsive pathway.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 2151384)

Published in J Physiol on December 21, 2006

Authors

Mark J Nijland1, Natalia E Schlabritz-Loutsevitch, Gene B Hubbard, Peter W Nathanielsz, Laura A Cox

Author Affiliations

1: Department of Obstetrics and Gynecology and Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, TX, USA.

Articles citing this

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest (2009) 3.10

Why primate models matter. Am J Primatol (2014) 2.05

Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol (2007) 1.49

Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. J Physiol (2010) 1.35

Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS One (2011) 1.13

Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products. Endocrinology (2009) 1.11

Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention. J Neurosci Methods (2010) 1.03

Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Am J Obstet Gynecol (2008) 0.92

Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance. J Endocrinol (2013) 0.90

A high protein diet during pregnancy affects hepatic gene expression of energy sensing pathways along ontogenesis in a porcine model. PLoS One (2011) 0.87

Baboons as a model to study genetics and epigenetics of human disease. ILAR J (2013) 0.87

Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring. Am J Physiol Regul Integr Comp Physiol (2010) 0.86

Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on {beta}1- and {beta}2-adrenergic receptors in the fetal baboon liver. Reprod Sci (2010) 0.83

Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity. J Obes (2012) 0.83

A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model. BMC Genomics (2012) 0.79

A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome. J Physiol (2012) 0.79

Effects of maternal nutrient restriction, intrauterine growth restriction, and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro. J Med Primatol (2013) 0.79

Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep. J Nutr Biochem (2010) 0.78

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation. Am J Physiol Renal Physiol (2015) 0.77

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development. FASEB J (2014) 0.77

Baboon fetal arterial endothelial cells are more responsive to challenge by tumor necrosis factor α (TNF-α) than baboon fetal umbilical vein endothelial cells. Atherosclerosis (2010) 0.76

Walking speed as an aging biomarker in baboons (Papio hamadryas). J Med Primatol (2015) 0.76

Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan. Front Genet (2016) 0.75

Increased aggressive and affiliative display behavior in intrauterine growth restricted baboons. J Med Primatol (2015) 0.75

Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol (2017) 0.75

Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype. J Med Primatol (2017) 0.75

Articles cited by this

The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05

MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol (2003) 20.83

The biology of vascular endothelial growth factor. Endocr Rev (1997) 13.70

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem (1992) 4.92

Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr (2005) 4.57

Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol (2004) 2.90

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J Endocrinol (2004) 2.20

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis. J Clin Invest (1997) 1.79

Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci STKE (2006) 1.79

Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am J Pathol (2003) 1.63

Mechanisms in protein O-glycan biosynthesis and clinical and molecular aspects of protein O-glycan biosynthesis defects: a review. Clin Chem (2006) 1.46

Development of a system for individual feeding of baboons maintained in an outdoor group social environment. J Med Primatol (2004) 1.41

Effect of 30 per cent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression. J Physiol (2006) 1.29

The role of imprinted genes in fetal growth. Biol Neonate (2002) 1.19

Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. Physiol Genomics (2004) 1.17

Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes. Am J Physiol (1997) 1.12

Glucocorticoid down-regulation of rat glucocorticoid receptor does not involve differential promoter regulation. J Endocrinol (2004) 0.90

Articles by these authors

Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol (2004) 2.90

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci (2003) 2.67

Poor nutrition during pregnancy and lactation negatively affects neurodevelopment of the offspring: evidence from a translational primate model. Am J Clin Nutr (2013) 2.44

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci (2009) 2.08

Why primate models matter. Am J Primatol (2014) 2.05

Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci (2005) 1.85

Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatr Res (2002) 1.82

Spontaneous heart disease in the adult chimpanzee (Pan troglodytes). J Med Primatol (2008) 1.72

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol (2008) 1.68

The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. Pediatr Res (2007) 1.61

Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons. J Med Primatol (2009) 1.55

Up-regulation of the fetal baboon hypothalamo-pituitary-adrenal axis in intrauterine growth restriction: coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation. Endocrinology (2013) 1.51

Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays. Clin Vaccine Immunol (2006) 1.50

Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Proc Natl Acad Sci U S A (2009) 1.45

A live attenuated vaccine for Lassa fever made by reassortment of Lassa and Mopeia viruses. J Virol (2005) 1.42

The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC Med (2005) 1.41

Development of a system for individual feeding of baboons maintained in an outdoor group social environment. J Med Primatol (2004) 1.41

Maternal nutrient restriction affects properties of skeletal muscle in offspring. J Physiol (2006) 1.40

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome (2010) 1.40

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? PLoS One (2011) 1.39

Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proc Natl Acad Sci U S A (2011) 1.39

Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors. Exp Biol Med (Maywood) (2009) 1.39

Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. J Physiol (2010) 1.35

Spontaneous neoplasia in the baboon (Papio spp.). J Med Primatol (2007) 1.34

Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequences. Am J Physiol Regul Integr Comp Physiol (2009) 1.30

Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension (2012) 1.28

Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region. Infect Immun (2005) 1.28

Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology (2009) 1.27

Prenatal origins of adult disease. Curr Opin Obstet Gynecol (2008) 1.26

Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle. Am J Physiol Endocrinol Metab (2009) 1.24

Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle. Biol Reprod (2004) 1.23

Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy, and increased liver weight in the fetal sheep. Biol Reprod (2003) 1.20

Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms. BMC Physiol (2011) 1.19

Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol (2002) 1.19

A review of spontaneous neoplasia in baboons (Papio spp.). J Med Primatol (2005) 1.13

A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity. Vaccine (2007) 1.13

Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products. Endocrinology (2009) 1.11

A novel Brucella isolate in association with two cases of stillbirth in non-human primates - first report. J Med Primatol (2009) 1.07

Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB J (2010) 1.05

Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention. J Neurosci Methods (2010) 1.03

Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the rat. Pediatr Res (2008) 1.02

Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep. Inflamm Bowel Dis (2010) 1.01

Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats. Pharm Res (2004) 1.01

Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring. Biol Reprod (2011) 1.01

Emergence of insulin resistance in juvenile baboon offspring of mothers exposed to moderate maternal nutrient reduction. Am J Physiol Regul Integr Comp Physiol (2011) 1.00

Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. J Pharm Sci (2004) 0.99

The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. Reprod Sci (2008) 0.99

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. J Gerontol A Biol Sci Med Sci (2011) 0.99

Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. Prostaglandins Leukot Essent Fatty Acids (2012) 0.99

Spontaneous pathology of the common marmoset (Callithrix jacchus) and tamarins (Saguinus oedipus, Saguinus mystax). J Med Primatol (2009) 0.98

Mortality in captive baboons with seizures: a new model for SUDEP? Epilepsia (2009) 0.98

Prenatal dexamethasone leads to both endothelial dysfunction and vasodilatory compensation in sheep. J Physiol (2003) 0.98

Sex-dependent cognitive performance in baboon offspring following maternal caloric restriction in pregnancy and lactation. Reprod Sci (2012) 0.98

The influence of maternal early to mid-gestation nutrient restriction on long chain polyunsaturated fatty acids in fetal sheep. Lipids (2008) 0.97

Developmental changes in cerebral autoregulatory capacity in the fetal sheep parietal cortex. J Physiol (2002) 0.97

The frequency of lymphocytic and reflux esophagitis in non-human primates. Int J Clin Exp Pathol (2008) 0.97

Natural Chagas disease in four baboons. J Med Primatol (2008) 0.97

Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep. Am J Physiol Regul Integr Comp Physiol (2002) 0.97

Maternal obesity induces fibrosis in fetal myocardium of sheep. Am J Physiol Endocrinol Metab (2010) 0.96

Natural pathology of the Baboon (Papio spp.). J Med Primatol (2011) 0.96

Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol Reprod (2004) 0.96

Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Comp Biochem Physiol Part D Genomics Proteomics (2010) 0.96

Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res (2003) 0.96

Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab Dispos (2005) 0.95

Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J (2013) 0.95

Molecular pathways mediating differential responses to lipopolysaccharide between human and baboon arterial endothelial cells. Clin Exp Pharmacol Physiol (2009) 0.95

Trypanosoma cruzi in non-human primates with a history of stillbirths: a retrospective study (Papio hamadryas spp.) and case report (Macaca fascicularis). J Med Primatol (2008) 0.95

Localization of genes that control LDL size fractions in baboons. Atherosclerosis (2003) 0.95

The baboon model (Papio hamadryas) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome. J Med Primatol (2008) 0.94

The columnar-lined mucosa in the distal esophagus. A preliminary study in baboons. In Vivo (2009) 0.94

Maternal nutrient restriction alters gene expression in the ovine fetal heart. J Physiol (2004) 0.93

Sexually dimorphic effects of maternal nutrient reduction on expression of genes regulating cortisol metabolism in fetal baboon adipose and liver tissues. Diabetes (2012) 0.93

Reductions in serum IGF-1 during aging impair health span. Aging Cell (2013) 0.93

Effects of three courses of maternally administered dexamethasone at 0.7, 0.75, and 0.8 of gestation on prenatal and postnatal growth in sheep. Pediatrics (2004) 0.93

A case report of hepatocellular carcinoma and focal nodular hyperplasia with a myelolipoma in two chimpanzees and a review of spontaneous hepatobiliary tumors in non-human primates. J Med Primatol (2004) 0.93

Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons. Am J Physiol Heart Circ Physiol (2007) 0.93

A genomewide linkage scan for quantitative trait loci influencing the craniofacial complex in baboons (Papio hamadryas spp.). Genetics (2008) 0.92

Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms?--a pathological point of view. Age (Dordr) (2006) 0.92

Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr) (2010) 0.92

Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. J Nutr Biochem (2007) 0.92

The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. Pediatr Res (2003) 0.92

Pathology of spontaneous air sacculitis in 37 baboons and seven chimpanzees and a brief review of the literature. J Med Primatol (2012) 0.91

Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies. Nutr Rev (2013) 0.91

Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One (2007) 0.91

Maternal obesity, lipotoxicity and cardiovascular diseases in offspring. J Mol Cell Cardiol (2012) 0.91

Determinants of variation in serum paraoxonase enzyme activity in baboons. J Lipid Res (2005) 0.91

Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep. Obstet Gynecol (2009) 0.91

Enhanced transforming growth factor-beta signaling and fibrogenesis in ovine fetal skeletal muscle of obese dams at late gestation. Am J Physiol Endocrinol Metab (2010) 0.91

Spontaneous ovarian tumors in twelve baboons: a review of ovarian neoplasms in non-human primates. J Med Primatol (2003) 0.91

Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function in aged female offspring. Am J Physiol Regul Integr Comp Physiol (2012) 0.90

Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development. Reprod Biol Endocrinol (2010) 0.90

Dose-response effects of betamethasone on maturation of the fetal sheep lung. Am J Obstet Gynecol (2009) 0.90