Published in ChemMedChem on March 01, 2006
Mapping the conformational space accessible to catechol-O-methyltransferase. Acta Crystallogr D Biol Crystallogr (2014) 0.84
Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders. Br J Clin Pharmacol (2014) 0.78
Fluorine in pharmaceuticals: looking beyond intuition. Science (2007) 8.98
Interactions with aromatic rings in chemical and biological recognition. Angew Chem Int Ed Engl (2003) 5.63
Aromatic rings in chemical and biological recognition: energetics and structures. Angew Chem Int Ed Engl (2011) 2.48
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest (2002) 2.47
Trace amine-associated receptor 1 modulates dopaminergic activity. J Pharmacol Exp Ther (2007) 1.69
Systematic investigation of halogen bonding in protein-ligand interactions. Angew Chem Int Ed Engl (2011) 1.54
Orthogonal multipolar interactions in structural chemistry and biology. Angew Chem Int Ed Engl (2005) 1.54
Predicting and tuning physicochemical properties in lead optimization: amine basicities. ChemMedChem (2007) 1.48
Spirocyclic oxetanes: synthesis and properties. Angew Chem Int Ed Engl (2008) 1.44
The pleasure and importance of printed journals. Nature (2009) 1.39
Molecular recognition in chemical and biological systems. Angew Chem Int Ed Engl (2015) 1.28
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiol Aging (2006) 1.26
Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophrenia. Neuropharmacology (2011) 1.23
Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand. Angew Chem Int Ed Engl (2005) 1.20
Structural aspects of fullerene chemistry--a journey through fullerene chirality. Chem Rev (2006) 1.17
RO4938581, a novel cognitive enhancer acting at GABAA alpha5 subunit-containing receptors. Psychopharmacology (Berl) (2008) 1.17
Phosphate recognition in structural biology. Angew Chem Int Ed Engl (2007) 1.17
Regio- and stereoselective tether-directed remote functionalization of C60 with derivatives of the Tröger base. Angew Chem Int Ed Engl (2004) 1.15
Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J Neurosci (2002) 1.14
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A (2011) 1.09
Steroids in Molecular Recognition. Chem Rev (1997) 1.09
Efficient synthesis of 5-hydroxymethylcytosine containing DNA. Org Lett (2010) 1.07
Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalised 6,6-dicyanopentafulvene with an intense, low-energy charge-transfer band. Chem Commun (Camb) (2011) 1.06
Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone. PLoS One (2012) 1.06
Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol (2009) 1.05
Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles. Chembiochem (2004) 0.99
Container molecules with portals: Reversibly switchable cycloalkane complexation. Angew Chem Int Ed Engl (2007) 0.99
A two-dimensional polymer prepared by organic synthesis. Nat Chem (2012) 0.98
Modification of supramolecular binding motifs induced by substrate registry: formation of self-assembled macrocycles and chain-like patterns. Chemistry (2009) 0.97
Amphiphilic dendrimers: novel self-assembling vectors for efficient gene delivery. Angew Chem Int Ed Engl (2003) 0.96
Orthogonal dipolar interactions between amide carbonyl groups. Proc Natl Acad Sci U S A (2008) 0.95
Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites. J Org Chem (2008) 0.95
Allenes in molecular materials. Angew Chem Int Ed Engl (2012) 0.95
Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. Chembiochem (2009) 0.94
Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity. Pharmacogenomics J (2002) 0.93
Geometrically precisely defined multinanometer expansion/contraction motions in a resorcin[4]arene cavitand based molecular switch. Angew Chem Int Ed Engl (2005) 0.93
Supramolecular patterned surfaces driven by cooperative assembly of C60 and porphyrins on metal substrates. Angew Chem Int Ed Engl (2004) 0.93
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions. Org Biomol Chem (2004) 0.93
A weak attractive interaction between organic fluorine and an amide group. Angew Chem Int Ed Engl (2004) 0.92
The fluorine-iminium ion gauche effect: proof of principle and application to asymmetric organocatalysis. Angew Chem Int Ed Engl (2009) 0.92
Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions. Angew Chem Int Ed Engl (2009) 0.92
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. J Mol Biol (2007) 0.91
Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor. Biol Psychiatry (2003) 0.90
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions. Angew Chem Int Ed Engl (2003) 0.90
Molecular pair analysis: C-H...F interactions in the crystal structure of fluorobenzene? And related matters. Chemistry (2006) 0.90
Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain. PLoS One (2013) 0.90
Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 A resolution. Acta Crystallogr D Biol Crystallogr (2005) 0.89
Directed rotations of single porphyrin molecules controlled by localized force spectroscopy. ACS Nano (2012) 0.89
The search for tricyanomethane (cyanoform). Chemistry (2010) 0.89
Designing fluorinated cinchona alkaloids for enantioselective catalysis: controlling internal rotation by a fluorine-ammonium ion gauche effect (φ(NCCF)). Chemistry (2012) 0.89
Inhibitors of the herbicidal target IspD: allosteric site binding. Angew Chem Int Ed Engl (2011) 0.88
The state of the art of chemical biology. Chembiochem (2009) 0.88
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem (2010) 0.88
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV. Angew Chem Int Ed Engl (2006) 0.87
Molecular torsion balances: evidence for favorable orthogonal dipolar interactions between organic fluorine and amide groups. Angew Chem Int Ed Engl (2007) 0.87
Property tuning in charge-transfer chromophores by systematic modulation of the spacer between donor and acceptor. Chemistry (2007) 0.87
Efficient stacking on protein amide fragments. ChemMedChem (2013) 0.87
Supramolecular [60]fullerene chemistry on surfaces. Chem Soc Rev (2006) 0.87
Conjugated oligoenynes based on the diethynylethene unit. Chem Rev (2005) 0.87
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters. Chemistry (2012) 0.87
Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice. Behav Pharmacol (2008) 0.86
Structure elucidation of hexabromocyclododecanes--a class of compounds with a complex stereochemistry. Chemosphere (2005) 0.85
Theoretical and X-ray crystallographic evidence of a fluorine-imine gauche effect: an addendum to Dunathan's stereoelectronic hypothesis. Chemistry (2011) 0.85
Calculation of binding free energies of inhibitors to plasmepsin II. J Comput Chem (2011) 0.85
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water. Chemistry (2011) 0.85
Triply fused Zn(II)-porphyrin oligomers: synthesis, properties, and supramolecular interactions with single-walled carbon nanotubes (SWNTs). Chemistry (2006) 0.84
Halogen bonding of (iodoethynyl)benzene derivatives in solution. Org Lett (2014) 0.84
A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values. ChemMedChem (2006) 0.84
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. Angew Chem Int Ed Engl (2006) 0.84
Reactions of the HCN-tetramer with aldehydes. Chem Biodivers (2007) 0.84
A multistep single-crystal-to-single-crystal bromodiacetylene dimerization. Nat Chem (2013) 0.83
Practical, highly active, and enantioselective ferrocenyl-imidazoline palladacycle catalysts (FIPs) for the aza-Claisen rearrangement of N-para-methoxyphenyl trifluoroacetimidates. Angew Chem Int Ed Engl (2006) 0.83
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. ChemMedChem (2007) 0.83
Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem (2010) 0.83
Shape-persistent chiral alleno-acetylenic macrocycles and cyclophanes by acetylenic scaffolding with 1,3-diethynylallenes. Angew Chem Int Ed Engl (2005) 0.83
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum. ChemMedChem (2010) 0.83
Soluble poly(diacetylene)s using the perfluorophenyl-phenyl motif as a supramolecular synthon. J Am Chem Soc (2008) 0.83
A supramolecular multiposition rotary device. Angew Chem Int Ed Engl (2007) 0.83
Nanoscale engineering of molecular porphyrin wires on insulating surfaces. Small (2008) 0.83
Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew Chem Int Ed Engl (2009) 0.83
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors. Acta Crystallogr D Biol Crystallogr (2012) 0.83
Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. ChemMedChem (2008) 0.83
Perfluorophenyl-phenyl interactions in the crystallization and topochemical polymerization of triacetylene monomers. Chemistry (2009) 0.83