Published in Chem Rev on August 01, 2006
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Formation, structure, and EPR detection of a high spin Fe(IV)-oxo species derived from either an Fe(III)-oxo or Fe(III)-OH complex. J Am Chem Soc (2010) 1.44
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Nontargeted biomonitoring of halogenated organic compounds in two ecotypes of bottlenose dolphins (Tursiops truncatus) from the Southern California Bight. Environ Sci Technol (2015) 0.81
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A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angew Chem Int Ed Engl (2014) 0.79
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The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids. Synlett (2012) 0.78
Paramagnetic nuclear magnetic resonance relaxation and molecular mechanics studies of the chloroperoxidase-indole complex: insights into the mechanism of chloroperoxidase-catalyzed regioselective oxidation of indole. Biochemistry (2013) 0.78
Vanadium-Catalyzed C(sp(3))-H Fluorination Reactions. Org Chem Front (2014) 0.78
Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase. J Am Chem Soc (2016) 0.78
Dioxygen activation by nonheme iron enzymes with the 2-His-1-carboxylate facial triad that generate high-valent oxoiron oxidants. J Biol Inorg Chem (2017) 0.77
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Identification and Spectroscopic Characterization of Nonheme Iron(III) Hypochlorite Intermediates. Angew Chem Weinheim Bergstr Ger (2015) 0.75
A high-throughput assay for arylamine halogenation based on a peroxidase-mediated quinone-amine coupling with applications in the screening of enzymatic halogenations. Chemistry (2014) 0.75
Insights into enzymatic halogenation from computational studies. Front Chem (2014) 0.75
Halogenase-Inspired Oxidative Chlorination Using Flavin Photocatalysis. Angew Chem Int Ed Engl (2016) 0.75
A metagenomic-based survey of microbial (de)halogenation potential in a German forest soil. Sci Rep (2016) 0.75
Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J Mol Biol (2016) 0.75
The past, present, and future of the Yang reaction. Org Biomol Chem (2016) 0.75
Regioselectivity of substrate hydroxylation versus halogenation by a nonheme iron(IV)-oxo complex: possibility of rearrangement pathways. J Biol Inorg Chem (2012) 0.75
VTST/MT studies of the catalytic mechanism of C-H activation by transition metal complexes with [Cu2(μ-O2)], [Fe2(μ-O2)] and Fe(IV)-O cores based on DFT potential energy surfaces. J Biol Inorg Chem (2017) 0.75
Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling. ACS Catal (2017) 0.75
Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp(3))-H Bonds. J Am Chem Soc (2017) 0.75
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev (2006) 7.69
Antibiotics for emerging pathogens. Science (2009) 7.39
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Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiol Mol Biol Rev (2002) 5.12
Protein posttranslational modifications: the chemistry of proteome diversifications. Angew Chem Int Ed Engl (2005) 4.10
Non-heme Fe(IV)-oxo intermediates. Acc Chem Res (2007) 3.55
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. Nat Chem Biol (2007) 3.33
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis. Nature (2005) 2.91
New antibiotics from bacterial natural products. Nat Biotechnol (2006) 2.72
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A (2006) 2.63
BluB cannibalizes flavin to form the lower ligand of vitamin B12. Nature (2007) 2.53
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. Nature (2006) 2.52
How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol (2006) 2.45
Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase. Nature (2008) 2.39
Automated genome mining for natural products. BMC Bioinformatics (2009) 2.29
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry (2006) 2.22
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A (2007) 2.22
SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase. Proc Natl Acad Sci U S A (2005) 2.12
Halogenation strategies in natural product biosynthesis. Chem Biol (2008) 2.08
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
Vancomycin assembly: nature's way. Angew Chem Int Ed Engl (2003) 1.99
Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. ACS Chem Biol (2007) 1.94
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol (2002) 1.90
A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.89
Labeling proteins with small molecules by site-specific posttranslational modification. J Am Chem Soc (2004) 1.84
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains. Nat Struct Biol (2002) 1.82
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.82
Site-specific protein labeling by Sfp phosphopantetheinyl transferase. Nat Protoc (2006) 1.82
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.80
Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. Chem Biol (2002) 1.75
A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines. Nature (2007) 1.74
Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. Biochemistry (2007) 1.69
Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry (2009) 1.69
Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nat Chem Biol (2007) 1.68
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature (2008) 1.66
Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB. Proc Natl Acad Sci U S A (2011) 1.66
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chem Biol (2004) 1.61
The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria. Science (2010) 1.59
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.58
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc Natl Acad Sci U S A (2002) 1.57
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep (2008) 1.56
An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol (2012) 1.56
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol (2012) 1.55
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis. J Am Chem Soc (2006) 1.53
In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci U S A (2004) 1.52
Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. J Am Chem Soc (2010) 1.51
CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci U S A (2003) 1.50
Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chem Biol (2002) 1.49
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (2002) 1.49
Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan. Biochemistry (2009) 1.48
Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2. Proc Natl Acad Sci U S A (2009) 1.47
In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc (2005) 1.47
Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. Biochemistry (2004) 1.45
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proc Natl Acad Sci U S A (2003) 1.45
Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. Chembiochem (2004) 1.45
Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. J Am Chem Soc (2006) 1.45
Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line. J Am Chem Soc (2006) 1.44
Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase. Chem Biol (2004) 1.44
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. Chem Biol (2002) 1.44
GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin. Biochemistry (2006) 1.42
Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics. Proc Natl Acad Sci U S A (2010) 1.42
Maturation of an Escherichia coli ribosomal peptide antibiotic by ATP-consuming N-P bond formation in microcin C7. J Am Chem Soc (2008) 1.41
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin. J Am Chem Soc (2008) 1.41
Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. Chem Biol (2002) 1.41
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Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces. J Am Chem Soc (2007) 1.40
Structural insights into nonribosomal peptide enzymatic assembly lines. Nat Prod Rep (2009) 1.40
Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides. Chembiochem (2010) 1.40
The future of aminoglycosides: the end or renaissance? Chembiochem (2010) 1.39
Biomimetic synthesis and optimization of cyclic peptide antibiotics. Nature (2002) 1.39
Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid. J Am Chem Soc (2006) 1.39
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In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. Biochemistry (2006) 1.32
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Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. J Am Chem Soc (2009) 1.28
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Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. Biochemistry (2006) 1.28
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Chem Biol (2006) 1.25
Anthranilate-activating modules from fungal nonribosomal peptide assembly lines. Biochemistry (2010) 1.25