Published in Chembiochem on September 01, 2006
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep (2008) 1.32
Epoxide-opening cascades in the synthesis of polycyclic polyether natural products. Angew Chem Int Ed Engl (2009) 1.13
Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Appl Environ Microbiol (2011) 0.94
Type II thioesterase ScoT, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference for propionate. Appl Environ Microbiol (2008) 0.91
Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. Appl Environ Microbiol (2008) 0.83
Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol (2008) 0.83
Roles of type II thioesterases and their application for secondary metabolite yield improvement. Appl Microbiol Biotechnol (2014) 0.79
Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding. Beilstein J Org Chem (2014) 0.77
DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis. J Ind Microbiol Biotechnol (2016) 0.75
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A (2004) 3.52
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat Biotechnol (2007) 3.45
Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem Biol (2005) 2.61
Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol (2005) 2.57
CENP-C is a structural platform for kinetochore assembly. Curr Biol (2011) 2.52
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol (2004) 2.01
The structure of docking domains in modular polyketide synthases. Chem Biol (2003) 1.98
Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature (2004) 1.70
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ. EMBO J (2007) 1.66
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes. Proc Natl Acad Sci U S A (2006) 1.63
Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chem Biol (2009) 1.57
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J Bacteriol (2005) 1.55
Increasing the efficiency of heterologous promoters in actinomycetes. J Mol Microbiol Biotechnol (2002) 1.46
Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway. Chem Biol (2005) 1.42
omega-Transaminases for the synthesis of non-racemic alpha-chiral primary amines. Trends Biotechnol (2010) 1.35
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. Chem Commun (Camb) (2003) 1.33
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep (2008) 1.32
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chem Biol (2008) 1.32
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. Mol Microbiol (2003) 1.31
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chem Biol (2006) 1.29
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase. Chembiochem (2005) 1.27
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs. PLoS Negl Trop Dis (2008) 1.27
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol (2007) 1.27
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chem Biol (2006) 1.27
Active-site residue, domain and module swaps in modular polyketide synthases. J Ind Microbiol Biotechnol (2003) 1.24
Physiological responses and perceived exertion during international Taekwondo competition. Int J Sports Physiol Perform (2009) 1.21
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. Chem Commun (Camb) (2005) 1.21
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem (2008) 1.19
Recent biocatalytic oxidation-reduction cascades. Curr Opin Chem Biol (2010) 1.17
Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin. Angew Chem Int Ed Engl (2006) 1.16
A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J Biol Chem (2009) 1.16
Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chem Biol (2006) 1.15
The fluorinase from Streptomyces cattleya is also a chlorinase. Angew Chem Int Ed Engl (2006) 1.13
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chem Biol (2004) 1.11
Asymmetric bioreduction of activated alkenes using cloned 12-oxophytodienoate reductase isoenzymes OPR-1 and OPR-3 from Lycopersicon esculentum (tomato): a striking change of stereoselectivity. Angew Chem Int Ed Engl (2007) 1.09
Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity. ACS Chem Biol (2010) 1.09
Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions. Chemistry (2004) 1.08
Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. J Biol Chem (2010) 1.08
Stereocomplementary bioreduction of alpha,beta-unsaturated dicarboxylic acids and dimethyl esters using enoate reductases: enzyme- and substrate-based stereocontrol. Org Lett (2007) 1.05
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol (2002) 1.04
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. BMC Genomics (2008) 1.04
Cell-cycle inhibition by Helicobacter pylori L-asparaginase. PLoS One (2010) 1.04
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest (2013) 1.04
A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin. J Biol Chem (2007) 1.02
A novel mycolactone toxin obtained by biosynthetic engineering. Chembiochem (2007) 1.02
High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chem Biol (2006) 1.02
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proc Natl Acad Sci U S A (2011) 1.02
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem (2008) 1.01
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones. Chem Commun (Camb) (2003) 1.01
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain. Chem Biol (2007) 1.00
Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters. Chem Biol (2010) 0.99
Redox self-sufficient biocatalyst network for the amination of primary alcohols. Angew Chem Int Ed Engl (2012) 0.99
Orchestration of concurrent oxidation and reduction cycles for stereoinversion and deracemisation of sec-alcohols. J Am Chem Soc (2008) 0.99
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. Microbiology (2005) 0.98
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin. J Biotechnol (2004) 0.98
Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem (2008) 0.98
Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. J Am Chem Soc (2004) 0.98
Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. Chembiochem (2004) 0.98
Formal asymmetric biocatalytic reductive amination. Angew Chem Int Ed Engl (2008) 0.98
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Org Biomol Chem (2003) 0.97
A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster. Chembiochem (2011) 0.97
Biocatalytic organic synthesis of optically pure (S)-scoulerine and berbine and benzylisoquinoline alkaloids. J Org Chem (2011) 0.97
Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. J Biol Chem (2011) 0.97
Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. Biochemistry (2002) 0.96
Insights into the stereospecificity of ketoreduction in a modular polyketide synthase. Org Biomol Chem (2011) 0.96
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. Org Biomol Chem (2005) 0.95
Mycolactone gene expression is controlled by strong SigA-like promoters with utility in studies of Mycobacterium ulcerans and buruli ulcer. PLoS Negl Trop Dis (2009) 0.95