Published in Nat Biotechnol on March 18, 2007
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350. J Bacteriol (2008) 4.59
Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep (2009) 3.74
Natural products version 2.0: connecting genes to molecules. J Am Chem Soc (2010) 3.06
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell (2014) 2.59
ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res (2008) 2.34
Modern natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod (2010) 1.90
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat Biotechnol (2009) 1.68
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
Combination therapies for combating antimicrobial resistance. Curr Opin Microbiol (2011) 1.37
Taxonomy, Physiology, and Natural Products of Actinobacteria. Microbiol Mol Biol Rev (2015) 1.36
Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol (2010) 1.34
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae. DNA Res (2010) 1.32
ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Res (2012) 1.31
Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters. J Ind Microbiol Biotechnol (2010) 1.28
Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chem Biol (2008) 1.25
Strategies for mining fungal natural products. J Ind Microbiol Biotechnol (2013) 1.21
Exploration and mining of the bacterial terpenome. Acc Chem Res (2011) 1.21
High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A (2014) 1.20
Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria. Microbiol Mol Biol Rev (2012) 1.19
A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea. Proc Natl Acad Sci U S A (2008) 1.15
Triggers and cues that activate antibiotic production by actinomycetes. J Ind Microbiol Biotechnol (2013) 1.14
Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms). J Ind Microbiol Biotechnol (2011) 1.12
Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase. J Bacteriol (2008) 1.09
Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production. Microb Cell Fact (2009) 1.09
Strain improvement in actinomycetes in the postgenomic era. J Ind Microbiol Biotechnol (2011) 1.07
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product. J Am Chem Soc (2010) 1.04
Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes. J Bacteriol (2013) 1.04
Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery. J Ind Microbiol Biotechnol (2011) 1.04
Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59. Mar Drugs (2012) 1.02
Molecular evolution of hydrogen peroxide degrading enzymes. Arch Biochem Biophys (2012) 1.02
Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008. BMC Genomics (2012) 1.00
Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements. J Ind Microbiol Biotechnol (2013) 1.00
Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974. Antimicrob Agents Chemother (2009) 0.99
Secondary metabolite gene expression and interplay of bacterial functions in a tropical freshwater cyanobacterial bloom. ISME J (2014) 0.99
Interspecies modulation of bacterial development through iron competition and siderophore piracy. Mol Microbiol (2012) 0.97
Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides. J Ind Microbiol Biotechnol (2013) 0.96
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. BMC Genomics (2014) 0.95
Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination. Sci Rep (2011) 0.95
Antibiotics from microbes: converging to kill. Curr Opin Microbiol (2009) 0.95
Endophytic actinobacteria of medicinal plants: diversity and bioactivity. Antonie Van Leeuwenhoek (2015) 0.95
Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays. Microb Cell Fact (2007) 0.94
Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway. Mar Drugs (2008) 0.92
Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl Environ Microbiol (2008) 0.91
Inactivation of the lipopeptide antibiotic daptomycin by hydrolytic mechanisms. Antimicrob Agents Chemother (2011) 0.91
Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles. PLoS One (2010) 0.91
Regulation of the synthesis of the angucyclinone antibiotic alpomycin in Streptomyces ambofaciens by the autoregulator receptor AlpZ and its specific ligand. J Bacteriol (2008) 0.90
Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch. BMC Genomics (2013) 0.90
Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain. Microb Cell Fact (2012) 0.90
Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes. J Ind Microbiol Biotechnol (2015) 0.90
Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity. Front Microbiol (2015) 0.90
Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains. BMC Genomics (2013) 0.89
Knockout of the erythromycin biosynthetic cluster gene, eryBI, blocks isoflavone glucoside bioconversion during erythromycin fermentations in Aeromicrobium erythreum but not in Saccharopolyspora erythraea. Appl Environ Microbiol (2008) 0.89
Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Appl Environ Microbiol (2011) 0.89
Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach. BMC Genomics (2013) 0.88
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc (2017) 0.86
Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor. J Bacteriol (2008) 0.86
PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis. Microb Cell Fact (2009) 0.86
Investigation of the Amycolatopsis sp. strain ATCC 39116 vanillin dehydrogenase and its impact on the biotechnical production of vanillin. Appl Environ Microbiol (2012) 0.86
Draft Genome Sequence of Saccharopolyspora rectivirgula. Genome Announc (2014) 0.85
Genome-based studies of marine microorganisms to maximize the diversity of natural products discovery for medical treatments. Evid Based Complement Alternat Med (2011) 0.85
Identification of SACE_7040, a member of TetR family related to the morphological differentiation of Saccharopolyspora erythraea. Curr Microbiol (2011) 0.85
Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. Appl Environ Microbiol (2008) 0.83
A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor. Proc Natl Acad Sci U S A (2011) 0.83
Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. FEMS Microbiol Lett (2012) 0.83
Lessons learned from the transformation of natural product discovery to a genome-driven endeavor. J Ind Microbiol Biotechnol (2013) 0.83
Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol (2012) 0.83
Antibiotic production from the ground up. Nat Biotechnol (2007) 0.82
Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer. ACS Cent Sci (2016) 0.82
Natural products: Beyond grind and find. Nat Chem (2009) 0.82
Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products in Streptomyces. Proc Natl Acad Sci U S A (2015) 0.82
SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea. Microb Cell Fact (2013) 0.80
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics (2012) 0.80
Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17. Antimicrob Agents Chemother (2014) 0.80
Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects. J Antibiot (Tokyo) (2016) 0.80
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. J Ind Microbiol Biotechnol (2011) 0.79
SACE_0012, a TetR-family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea. Curr Microbiol (2013) 0.79
MbtH homology codes to identify gifted microbes for genome mining. J Ind Microbiol Biotechnol (2013) 0.79
Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp. Appl Environ Microbiol (2015) 0.78
Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome. Mol Cell Proteomics (2014) 0.78
A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus. Appl Environ Microbiol (2015) 0.78
Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. Antimicrob Agents Chemother (2012) 0.78
Natural products and synthetic biology. ACS Synth Biol (2014) 0.77
Differential roles of the hemerythrin-like proteins of Mycobacterium smegmatis in hydrogen peroxide and erythromycin susceptibility. Sci Rep (2015) 0.76
Genomic Changes Associated with the Loss of Nocardia brasiliensis Virulence in Mice after 200 In Vitro Passages. Infect Immun (2016) 0.76
Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations. Antimicrob Agents Chemother (2015) 0.76
rRNA (rrn) operon-engineered Bacillus subtilis as a feasible test organism for antibiotic discovery. Antimicrob Agents Chemother (2013) 0.76
Genome Sequence of Saccharopolyspora erythraea D, a Hyperproducer of Erythromycin. Genome Announc (2013) 0.76
Multiplexed Integrating Plasmids for Engineering of the Erythromycin Gene Cluster for Expression in Streptomyces spp. and Combinatorial Biosynthesis. Appl Environ Microbiol (2015) 0.76
Gifted microbes for genome mining and natural product discovery. J Ind Microbiol Biotechnol (2016) 0.76
The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli. J Vis Exp (2013) 0.75
Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis. FEMS Microbiol Lett (2015) 0.75
Strain improvement and optimization studies for enhanced production of erythromycin in bagasse based medium using Saccharopolyspora erythraea MTCC 1103. 3 Biotech (2013) 0.75
Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections. Clin Microbiol Rev (2017) 0.75
Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea. Microb Cell Fact (2014) 0.75
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4. Appl Environ Microbiol (2010) 0.75
Tools for metabolic engineering in Streptomyces. Bioengineered (2014) 0.75
An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain. Appl Microbiol Biotechnol (2011) 0.75
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Nat Genet (2009) 8.30
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther (2006) 4.09
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A (2004) 3.52
Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases. Chem Biol (2005) 2.61
Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol (2005) 2.57
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. Nat Genet (2007) 2.35
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet (2007) 2.07
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol (2004) 2.01
The structure of docking domains in modular polyketide synthases. Chem Biol (2003) 1.98
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nat Genet (2008) 1.95
Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation. Am J Hum Genet (2006) 1.85
Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs. J Hypertens (2002) 1.67
Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans. J Bacteriol (2005) 1.55
Increasing the efficiency of heterologous promoters in actinomycetes. J Mol Microbiol Biotechnol (2002) 1.46
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans. Chem Commun (Camb) (2003) 1.33
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep (2008) 1.32
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chem Biol (2008) 1.32
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. Mol Microbiol (2003) 1.31
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase. Chem Biol (2006) 1.29
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol (2007) 1.27
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase. Chembiochem (2005) 1.27
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs. PLoS Negl Trop Dis (2008) 1.27
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chem Biol (2006) 1.27
Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly. Am J Hum Genet (2007) 1.26
Pacidamycin biosynthesis: identification and heterologous expression of the first uridyl peptide antibiotic gene cluster. Chembiochem (2010) 1.26
Active-site residue, domain and module swaps in modular polyketide synthases. J Ind Microbiol Biotechnol (2003) 1.24
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry. Chem Commun (Camb) (2005) 1.21
Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem (2008) 1.19
Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis. Chem Biol (2006) 1.15
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chem Biol (2004) 1.11
Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity. ACS Chem Biol (2010) 1.09
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol (2002) 1.04
Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones. BMC Genomics (2008) 1.04
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest (2013) 1.04
A novel mycolactone toxin obtained by biosynthetic engineering. Chembiochem (2007) 1.02
High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase. Chem Biol (2006) 1.02
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proc Natl Acad Sci U S A (2011) 1.02
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. Chembiochem (2008) 1.01
Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters. Chem Biol (2010) 0.99
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. Microbiology (2005) 0.98
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin. J Biotechnol (2004) 0.98
Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. Chembiochem (2008) 0.98
Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. Chembiochem (2004) 0.98
Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase. Org Biomol Chem (2003) 0.97
A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster. Chembiochem (2011) 0.97
Insights into the stereospecificity of ketoreduction in a modular polyketide synthase. Org Biomol Chem (2011) 0.96
Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase. Biochemistry (2002) 0.96
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine. Org Biomol Chem (2005) 0.95
Actinomycete integrative and conjugative pMEA-like elements of Amycolatopsis and Saccharopolyspora decoded. Plasmid (2008) 0.95
In vitro reconstruction of tetronate RK-682 biosynthesis. Nat Chem Biol (2009) 0.95
Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation. Chembiochem (2011) 0.94
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Mol Microbiol (2004) 0.94
Synthetic chain terminators off-load intermediates from a type I polyketide synthase. Chembiochem (2010) 0.93
In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines. Chem Commun (Camb) (2011) 0.93
Engineering of the spinosyn PKS: directing starter unit incorporation. J Nat Prod (2006) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Chain initiation on type I modular polyketide synthases revealed by limited proteolysis and ion-trap mass spectrometry. FEBS J (2005) 0.90
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun (Camb) (2003) 0.89
A polylinker approach to reductive loop swaps in modular polyketide synthases. Chembiochem (2008) 0.89
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci (2011) 0.88
Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases. Chembiochem (2008) 0.88
Skipping in a hybrid polyketide synthase. Evidence for ACP-to-ACP chain transfer. Chem Biol (2002) 0.88
Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angew Chem Int Ed Engl (2005) 0.88
Recent advances in the field of bioactive tetronates. Nat Prod Rep (2014) 0.88
Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked. Angew Chem Int Ed Engl (2005) 0.87
Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin. Chembiochem (2006) 0.87
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties. Org Biomol Chem (2008) 0.87
Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Org Biomol Chem (2003) 0.86
Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. J Biol Chem (2010) 0.86
Rapamycin biosynthesis: Elucidation of gene product function. Org Biomol Chem (2006) 0.86
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin. Microbiology (2006) 0.86
Improved catalytic activity of a purified multienzyme from a modular polyketide synthase after coexpression with Streptomyces chaperonins in Escherichia coli. Chembiochem (2008) 0.86
A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea. J Mol Microbiol Biotechnol (2004) 0.86
Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. Mol Microbiol (2002) 0.85
New rapamycin derivatives by precursor-directed biosynthesis. Chembiochem (2004) 0.85
Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus. Angew Chem Int Ed Engl (2004) 0.85
Insights into lasalocid A ring formation by chemical chain termination in vivo. Angew Chem Int Ed Engl (2011) 0.85
The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry. FEBS J (2009) 0.85