Published in Immunol Rev on August 01, 2006
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med (2008) 6.07
Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol (2009) 4.66
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 2.84
TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov (2010) 2.17
TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med (2007) 2.15
How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol (2010) 2.11
Modeling the repertoire of true tumor-specific MHC I epitopes in a human tumor. PLoS One (2009) 1.29
Role of regulatory T cells during virus infection. Immunol Rev (2013) 1.28
Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol (2008) 1.14
Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells. J Immunol (2008) 1.11
B cell-regulated immune responses in tumor models and cancer patients. Oncoimmunology (2013) 1.10
Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression. J Immunol (2010) 0.97
Increased number and function of FoxP3 regulatory T cells during experimental arthritis. Arthritis Rheum (2008) 0.96
Abnormal Tr1 differentiation in multiple sclerosis. J Neuroimmunol (2007) 0.91
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness. Nat Immunol (2010) 0.90
Dendritic cell-targeted pancreatic beta-cell antigen leads to conversion of self-reactive CD4(+) T cells into regulatory T cells and promotes immunotolerance in NOD mice. Rev Diabet Stud (2010) 0.89
Severe Developmental B Lymphopoietic Defects in Foxp3-Deficient Mice are Refractory to Adoptive Regulatory T Cell Therapy. Front Immunol (2012) 0.85
Cutting edge: TCR revision affects predominantly Foxp3 cells and skews them toward the Th17 lineage. J Immunol (2007) 0.84
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One (2012) 0.81
Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes. PLoS One (2009) 0.81
A mathematical model of immune activation with a unified self-nonself concept. Front Immunol (2013) 0.80
Human osteoclasts are inducible immunosuppressive cells in response to T cell-derived IFN-γ and CD40 ligand in vitro. J Bone Miner Res (2014) 0.78
Narrowing the Gap: Preserving Repertoire Diversity Despite Clonal Selection during the CD4 T Cell Response. Front Immunol (2015) 0.77
Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells. Sci Rep (2015) 0.76
The function of regulatory T cells at the ocular surface: Review. Ocul Surf (2017) 0.75
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91
Origin of regulatory T cells with known specificity for antigen. Nat Immunol (2002) 7.49
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
In vivo instruction of suppressor commitment in naive T cells. J Exp Med (2004) 5.47
DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci U S A (2003) 4.18
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A (2004) 4.12
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity (2006) 3.92
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer (2006) 3.89
Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell (2003) 3.86
Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study. Hepatology (2006) 3.18
Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol (2004) 2.82
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology (2002) 2.64
Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med (2012) 2.62
Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity (2007) 2.51
The requirement for cyclin D function in tumor maintenance. Cancer Cell (2012) 2.49
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 2.43
Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest (2011) 2.36
Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A (2010) 2.30
TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A (2009) 2.13
Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells. Hepatology (2013) 2.12
Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A (2007) 2.02
Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology (2008) 2.00
Identification of a T lineage-committed progenitor in adult blood. Immunity (2007) 2.00
Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol (2003) 1.97
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med (2011) 1.94
A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol (2002) 1.88
Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide-MHC class II chimera. Nat Immunol (2002) 1.81
Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta (2009) 1.75
Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes (2004) 1.73
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes. Nat Immunol (2004) 1.72
Thymic selection revisited: how essential is it? Immunol Rev (2003) 1.71
Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. Immunity (2006) 1.70
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med (2009) 1.69
Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol (2005) 1.66
The transcriptional landscape of αβ T cell differentiation. Nat Immunol (2013) 1.61
A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus. Proc Natl Acad Sci U S A (2006) 1.59
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. PLoS One (2008) 1.55
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci U S A (2002) 1.54
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med (2008) 1.49
Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood (2007) 1.48
In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci U S A (2010) 1.47
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 1.47
PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J Exp Med (2010) 1.47
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med (2005) 1.46
Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res (2010) 1.46
Miniaturized multichannel near infrared endoscope for mouse imaging. Mol Imaging (2003) 1.45
Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A (2002) 1.44
c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood (2006) 1.39
Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212. J Immunol (2009) 1.39
Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med (2003) 1.39
Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol (2002) 1.30
Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A (2008) 1.30
T cell receptor-instructed alphabeta versus gammadelta lineage commitment revealed by single-cell analysis. J Exp Med (2008) 1.30
Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med (2006) 1.29
On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes (2005) 1.29
Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med (2004) 1.28
The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer. Semin Cancer Biol (2006) 1.23
Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene (2002) 1.22
Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem (2009) 1.22
Enhancement of antigen-specific Treg vaccination in vivo. Proc Natl Acad Sci U S A (2010) 1.21
Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med (2011) 1.21
On the brink of becoming a T cell. Curr Opin Immunol (2002) 1.21
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol (2008) 1.20
Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma. EMBO Rep (2003) 1.18
Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol (2013) 1.17
Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res (2013) 1.16
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology (2009) 1.15
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling. Blood (2006) 1.15
Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol (2008) 1.14
Characterization of T cell differentiation in the murine gut. J Exp Med (2002) 1.14
The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med (2013) 1.14
Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One (2008) 1.14
Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur J Immunol (2003) 1.14
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice. Cancer Res (2011) 1.13
De novo production of antigen-specific suppressor cells in vivo. Nat Protoc (2006) 1.12
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med (2012) 1.12
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood (2009) 1.11
Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. PLoS One (2012) 1.07
Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J Exp Med (2006) 1.07
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis. J Clin Invest (2014) 1.07
Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J Biol Chem (2013) 1.06