| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
ER chaperones in mammalian development and human diseases.
|
FEBS Lett
|
2007
|
4.40
|
|
2
|
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.
|
J Biol Chem
|
2003
|
3.89
|
|
3
|
Stress induction of GRP78/BiP and its role in cancer.
|
Curr Mol Med
|
2006
|
3.70
|
|
4
|
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.
|
J Biol Chem
|
2006
|
3.31
|
|
5
|
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
|
Cancer Res
|
2007
|
2.82
|
|
6
|
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.
|
Cancer Res
|
2008
|
2.81
|
|
7
|
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.
|
Mol Cell Biol
|
2006
|
2.78
|
|
8
|
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting.
|
Biochem J
|
2011
|
2.74
|
|
9
|
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis.
|
Cancer Res
|
2007
|
2.26
|
|
10
|
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.
|
Cancer Biol Ther
|
2006
|
2.09
|
|
11
|
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
|
Proc Natl Acad Sci U S A
|
2008
|
2.07
|
|
12
|
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.
|
Antioxid Redox Signal
|
2009
|
1.98
|
|
13
|
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer.
|
Cancer Res
|
2006
|
1.96
|
|
14
|
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements.
|
J Biol Chem
|
2003
|
1.92
|
|
15
|
The critical role of GRP78 in physiologic and pathologic stress.
|
Curr Opin Cell Biol
|
2010
|
1.91
|
|
16
|
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
|
Blood
|
2011
|
1.79
|
|
17
|
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP.
|
J Biol Chem
|
2010
|
1.77
|
|
18
|
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.
|
Hum Pathol
|
2007
|
1.74
|
|
19
|
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.
|
Clin Cancer Res
|
2006
|
1.73
|
|
20
|
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.
|
Diabetes
|
2009
|
1.67
|
|
21
|
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP.
|
PLoS One
|
2009
|
1.58
|
|
22
|
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.
|
Mol Cancer Res
|
2008
|
1.58
|
|
23
|
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
|
Cancer Res
|
2005
|
1.55
|
|
24
|
Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting.
|
PLoS Genet
|
2006
|
1.48
|
|
25
|
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.
|
Proc Natl Acad Sci U S A
|
2008
|
1.47
|
|
26
|
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.
|
Mol Cell Biol
|
2005
|
1.46
|
|
27
|
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis.
|
Cancer Res
|
2011
|
1.40
|
|
28
|
ATF6 modulates SREBP2-mediated lipogenesis.
|
EMBO J
|
2004
|
1.36
|
|
29
|
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.
|
J Biol Chem
|
2003
|
1.36
|
|
30
|
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
|
J Clin Invest
|
2010
|
1.34
|
|
31
|
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.
|
Cell Rep
|
2013
|
1.34
|
|
32
|
Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation.
|
Biochem J
|
2002
|
1.33
|
|
33
|
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis.
|
Mol Cancer Ther
|
2009
|
1.25
|
|
34
|
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).
|
J Biol Chem
|
2011
|
1.24
|
|
35
|
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
|
Hepatology
|
2011
|
1.23
|
|
36
|
Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy.
|
PLoS One
|
2008
|
1.20
|
|
37
|
Endoplasmic reticulum stress.
|
Ann N Y Acad Sci
|
2007
|
1.18
|
|
38
|
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.
|
PLoS One
|
2013
|
1.16
|
|
39
|
Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.
|
J Cell Biochem
|
2004
|
1.16
|
|
40
|
Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.
|
Hepatology
|
2014
|
1.15
|
|
41
|
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.
|
J Exp Med
|
2012
|
1.14
|
|
42
|
Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation.
|
J Biol Chem
|
2005
|
1.12
|
|
43
|
Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo.
|
Nat Med
|
2004
|
1.11
|
|
44
|
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.
|
Clin Cancer Res
|
2013
|
1.10
|
|
45
|
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.
|
Mitochondrion
|
2010
|
1.07
|
|
46
|
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.
|
PLoS One
|
2011
|
1.07
|
|
47
|
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
|
Hum Gene Ther
|
2004
|
1.07
|
|
48
|
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
|
PLoS One
|
2010
|
1.05
|
|
49
|
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.
|
J Cell Physiol
|
2015
|
1.04
|
|
50
|
Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.
|
Am J Pathol
|
2010
|
1.02
|
|
51
|
GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.
|
Int J Cancer
|
2011
|
1.01
|
|
52
|
In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.
|
J Biol Chem
|
2006
|
1.00
|
|
53
|
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.
|
PLoS One
|
2012
|
0.97
|
|
54
|
Enantioselective synthesis of the lomaiviticin aglycon full carbon skeleton reveals remarkable remote substituent effects during the dimerization event.
|
Chemistry
|
2010
|
0.96
|
|
55
|
Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages.
|
Cancer Res
|
2002
|
0.94
|
|
56
|
Pronounced steric effects of substituents in the nazarov cyclization of aryl dienyl ketones.
|
Angew Chem Int Ed Engl
|
2008
|
0.94
|
|
57
|
GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling.
|
J Cell Physiol
|
2012
|
0.90
|
|
58
|
CDP and AP-2 mediated repression mechanism of the replication-dependent hamster histone H3.2 promoter.
|
J Cell Biochem
|
2002
|
0.89
|
|
59
|
GRP78 plays an essential role in adipogenesis and postnatal growth in mice.
|
FASEB J
|
2012
|
0.89
|
|
60
|
AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.
|
Int J Cancer
|
2013
|
0.89
|
|
61
|
The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.
|
Gynecol Oncol
|
2012
|
0.89
|
|
62
|
Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.
|
Cancer Res
|
2006
|
0.88
|
|
63
|
Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.
|
Stem Cells Dev
|
2013
|
0.84
|
|
64
|
Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8αβ+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis.
|
J Immunol
|
2012
|
0.83
|
|
65
|
Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes.
|
J Endocrinol
|
2011
|
0.82
|
|
66
|
Measurement and modification of the expression level of the chaperone protein and signaling regulator GRP78/BiP in mammalian cells.
|
Methods Enzymol
|
2011
|
0.80
|
|
67
|
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
|
Nature
|
2016
|
0.78
|
|
68
|
Impaired eyeblink conditioning in 78 kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice.
|
Behav Neurosci
|
2011
|
0.78
|
|
69
|
Enhanced photodynamic therapy efficacy with inducible suicide gene therapy controlled by the grp promoter.
|
Cancer Res
|
2002
|
0.76
|
|
70
|
Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial.
|
Mol Nutr Food Res
|
2011
|
0.76
|