Published in J Biol Chem on March 05, 2010
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene (2012) 2.82
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J (2011) 2.74
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J (2012) 2.45
The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol (2010) 1.91
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer (2014) 1.83
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood (2011) 1.79
Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones (2010) 1.69
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res (2011) 1.40
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo) (2012) 1.37
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). J Biol Chem (2011) 1.24
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS One (2013) 1.16
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner. PLoS One (2011) 1.15
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. Clin Cancer Res (2013) 1.10
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress. Mitochondrion (2010) 1.07
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. J Immunol (2011) 1.07
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol (2015) 1.06
Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis (2010) 1.02
Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78. Clin Cancer Res (2013) 0.99
The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78. PLoS One (2013) 0.98
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports (2014) 0.96
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. EMBO J (2014) 0.96
The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells. Biomed Res Int (2013) 0.95
Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface. J Biol Chem (2015) 0.93
Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics. PLoS Pathog (2016) 0.91
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis. FEBS Lett (2012) 0.91
A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death. PLoS One (2012) 0.90
Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity. Front Oncol (2015) 0.90
Protein disulfide isomerase in thrombosis and vascular inflammation. J Thromb Haemost (2013) 0.89
Protein Disulfide Isomerase Superfamily in Disease and the Regulation of Apoptosis. Endoplasmic Reticulum Stress Dis (2014) 0.89
An intronic variant in the GRP78, a stress-associated gene, improves prediction for liver cirrhosis in persistent HBV carriers. PLoS One (2011) 0.88
Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer (2015) 0.88
Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia. PLoS One (2013) 0.88
Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. Exp Cell Res (2014) 0.87
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores. J Biol Chem (2010) 0.87
GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients. Ann Oncol (2011) 0.87
Identification of potential tumor differentiation factor (TDF) receptor from steroid-responsive and steroid-resistant breast cancer cells. J Biol Chem (2011) 0.86
Secretion of novel SEL1L endogenous variants is promoted by ER stress/UPR via endosomes and shed vesicles in human cancer cells. PLoS One (2011) 0.86
Extracellular heat shock proteins: a new location, a new function. Shock (2013) 0.85
The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. J Biol Chem (2012) 0.84
Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis. Oncogene (2015) 0.83
The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M. BMC Cancer (2015) 0.83
A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store. PLoS One (2015) 0.82
Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PLoS One (2015) 0.82
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer. Cancers (Basel) (2014) 0.82
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. J Biol Chem (2015) 0.82
Heat shock 70-kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling. J Biol Chem (2014) 0.81
Endoplasmic reticulum chaperones and oxidoreductases: critical regulators of tumor cell survival and immunorecognition. Front Oncol (2014) 0.80
Involvement of membrane GRP78 in trophoblastic cell fusion. PLoS One (2012) 0.80
Regulating extracellular proteostasis capacity through the unfolded protein response. Prion (2015) 0.80
Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease. J Biol Chem (2013) 0.79
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ (2014) 0.79
Discovery of a novel target for the dysglycemic chromogranin A fragment pancreastatin: interaction with the chaperone GRP78 to influence metabolism. PLoS One (2014) 0.79
Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells. PLoS One (2013) 0.79
GRP78 at the Centre of the Stage in Cancer and Neuroprotection. Front Neurosci (2017) 0.78
The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells. Mol Cell Biochem (2015) 0.78
Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther (2016) 0.77
Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Front Oncol (2015) 0.77
JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction. PLoS One (2014) 0.77
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics. Front Oncol (2015) 0.76
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes. Proc Natl Acad Sci U S A (2016) 0.76
A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles. Viruses (2016) 0.75
Endoplasmic reticulum stress in beta cells and autoimmune diabetes. Curr Opin Immunol (2016) 0.75
Cell surface GRP78 as a biomarker and target for suppressing glioma cells. Sci Rep (2016) 0.75
Identification of novel amelogenin-binding proteins by proteomics analysis. PLoS One (2013) 0.75
Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers. J Nucl Med (2016) 0.75
Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy. Cell Stress Chaperones (2016) 0.75
Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death. Cell Death Differ (2017) 0.75
ROS-independent Nrf2 activation in prostate cancer. Oncotarget (2017) 0.75
HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget (2017) 0.75
HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum. Gene (2017) 0.75
An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell (1986) 10.38
GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res (2007) 4.73
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods (2005) 3.40
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem (2006) 3.31
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. J Biol Chem (2002) 3.02
The ER function BiP is a master regulator of ER function. Mt Sinai J Med (2004) 3.01
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell (2004) 2.99
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res (2007) 2.82
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell (2009) 2.80
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ (2008) 2.53
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. Cancer Res (2006) 2.15
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy. Cancer Biol Ther (2006) 2.09
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. J Biol Chem (2006) 2.01
GRP78: a multifunctional receptor on the cell surface. Antioxid Redox Signal (2009) 1.99
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal (2009) 1.98
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78. Cancer Res (2005) 1.94
Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2. Arch Virol (2004) 1.85
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol (2007) 1.64
GRP78, a coreceptor for coxsackievirus A9, interacts with major histocompatibility complex class I molecules which mediate virus internalization. J Virol (2002) 1.58
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One (2009) 1.58
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res (2008) 1.58
Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum. Cancer Res (2006) 1.55
Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry (2006) 1.48
Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene (2009) 1.47
Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Cancer Res (2000) 1.44
A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest (2008) 1.42
Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. Mol Cell Biol (2008) 1.42
Localization of GRP78 to mitochondria under the unfolded protein response. Biochem J (2006) 1.29
A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. Cell Signal (2004) 1.26
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol Cancer Ther (2009) 1.25
Cell surface expression of calnexin, a molecular chaperone in the endoplasmic reticulum. J Biol Chem (2000) 1.14
In vivo interrogation of the molecular display of atherosclerotic lesion surfaces. Am J Pathol (2003) 1.13
The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. J Immunol (2005) 1.10
Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78. Cancer Res (2007) 1.08
Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1. Cancer Res (2009) 1.05
The Par-4-GRP78 TRAIL, more twists and turns. Cancer Biol Ther (2009) 0.94
GRP78 as a marker of pre-eclampsia: an exploratory study. Mol Hum Reprod (2009) 0.83
Nucleosome dynamics define transcriptional enhancers. Nat Genet (2010) 5.94
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science (2008) 3.83
Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med (2006) 3.70
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem (2006) 3.31
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev (2010) 2.93
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res (2007) 2.82
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res (2008) 2.81
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol (2006) 2.78
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J (2011) 2.74
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res (2007) 2.26
The evolution of sex: a perspective from the fungal kingdom. Microbiol Mol Biol Rev (2010) 2.24
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell (2009) 2.15
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy. Cancer Biol Ther (2006) 2.09
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium. Proc Natl Acad Sci U S A (2008) 2.07
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal (2009) 1.98
GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res (2006) 1.96
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem (2003) 1.92
The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol (2010) 1.91
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood (2011) 1.79
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol (2007) 1.74
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Clin Cancer Res (2006) 1.73
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. Bioessays (2005) 1.69
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes (2009) 1.67
Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer (2002) 1.63
Identification of Hendra virus G glycoprotein residues that are critical for receptor binding. J Virol (2007) 1.61
Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One (2009) 1.58
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res (2008) 1.58
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment. Cancer Res (2005) 1.55
Subcapsular renal haematoma after holmium:yttrium-aluminum-garnet laser ureterolithotripsy. BJU Int (2011) 1.55
Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting. PLoS Genet (2006) 1.48
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses. Proc Natl Acad Sci U S A (2008) 1.47
Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol (2005) 1.46
A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res (2011) 1.40
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nat Cell Biol (2011) 1.36
ATF6 modulates SREBP2-mediated lipogenesis. EMBO J (2004) 1.36
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J Biol Chem (2003) 1.36
Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. Cancer Res (2009) 1.36
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. J Clin Invest (2010) 1.34
LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet (2010) 1.34
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep (2013) 1.34
SHORT HYPOCOTYL UNDER BLUE1 associates with MINISEED3 and HAIKU2 promoters in vivo to regulate Arabidopsis seed development. Plant Cell (2009) 1.31
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis. Mol Cancer Ther (2009) 1.25
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). J Biol Chem (2011) 1.24
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology (2011) 1.23
Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One (2008) 1.20
Endoplasmic reticulum stress. Ann N Y Acad Sci (2007) 1.18
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS One (2013) 1.16
Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6. J Cell Biochem (2004) 1.16
Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth. Am J Pathol (2010) 1.15
Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology (2014) 1.15
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer (2010) 1.14
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis. J Exp Med (2012) 1.14
Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads. BMC Genomics (2014) 1.12
Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem (2005) 1.12
Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo. Nat Med (2004) 1.11
Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. Clin Cancer Res (2013) 1.10
Arabidopsis SHORT HYPOCOTYL UNDER BLUE1 contains SPX and EXS domains and acts in cryptochrome signaling. Plant Cell (2006) 1.09
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. Blood (2008) 1.09
Transcriptional and hormonal signaling control of Arabidopsis seed development. Curr Opin Plant Biol (2010) 1.08
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress. Mitochondrion (2010) 1.07
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors. Hum Gene Ther (2004) 1.07
The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLoS One (2011) 1.07
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One (2010) 1.05
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol (2015) 1.04
Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma. Mol Cancer Ther (2010) 1.02
Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair. Mol Cell Biol (2008) 1.02
Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol (2010) 1.02
GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int J Cancer (2011) 1.01
In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4. J Biol Chem (2006) 1.00
Basic-zipper-type transcription factor FlbB controls asexual development in Aspergillus nidulans. Eukaryot Cell (2007) 1.00
RFI2, a RING-domain zinc finger protein, negatively regulates CONSTANS expression and photoperiodic flowering. Plant J (2006) 0.98
Activation of alpha 7 nicotinic acetylcholine receptor protects mice from radiation-induced intestinal injury and mortality. Radiat Res (2014) 0.98
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling. PLoS One (2012) 0.97
HYPERSENSITIVE TO RED AND BLUE 1, a ZZ-type zinc finger protein, regulates phytochrome B-mediated red and cryptochrome-mediated blue light responses. Plant Cell (2005) 0.97
Enantioselective synthesis of the lomaiviticin aglycon full carbon skeleton reveals remarkable remote substituent effects during the dimerization event. Chemistry (2010) 0.96
Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol (2010) 0.96
A WRKY transcription factor recruits the SYG1-like protein SHB1 to activate gene expression and seed cavity enlargement. PLoS Genet (2013) 0.94
Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages. Cancer Res (2002) 0.94
Pronounced steric effects of substituents in the nazarov cyclization of aryl dienyl ketones. Angew Chem Int Ed Engl (2008) 0.94
Light-regulated stomatal aperture in Arabidopsis. Mol Plant (2012) 0.93
Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers. Cancer Res (2012) 0.93
Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2. Cancer Res (2012) 0.93
The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans. PLoS One (2012) 0.93
HYPOSENSITIVE TO LIGHT, an alpha/beta fold protein, acts downstream of ELONGATED HYPOCOTYL 5 to regulate seedling de-etiolation. Mol Plant (2010) 0.92
Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer. Mol Cancer Res (2007) 0.92
Effect of initial fluid resuscitation on subsequent treatment in uncontrolled hemorrhagic shock in rats. Shock (2004) 0.92
PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies. J Nucl Med (2013) 0.92
GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol (2012) 0.90
Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring. Mol Pharm (2012) 0.90
The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target. PLoS One (2013) 0.90