Published in J Med Chem on August 24, 2006
Antiparasitic compounds that target DNA. Biochimie (2008) 2.00
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob Agents Chemother (2007) 1.44
Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology (2013) 1.07
In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi. Antimicrob Agents Chemother (2008) 1.03
Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. J Med Chem (2010) 1.00
DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site. J Mol Biol (2010) 0.96
Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. Bioorg Med Chem (2010) 0.89
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents. Eur J Med Chem (2008) 0.89
Efficacy of two novel 2,2'-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin. Drug Des Devel Ther (2012) 0.88
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorg Med Chem (2010) 0.84
In vivo investigations of selected diamidine compounds against Trypanosoma evansi using a mouse model. Antimicrob Agents Chemother (2009) 0.84
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum. Bioorg Med Chem (2009) 0.81
Neglected disease - african sleeping sickness: recent synthetic and modeling advances. Sci Pharm (2011) 0.80
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorg Med Chem (2013) 0.80
Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models. J Med Chem (2015) 0.78
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors. Bioorg Med Chem (2015) 0.78
Synthesis of N-substituted aryl amidines by strong base activation of amines. Tetrahedron Lett (2015) 0.77
Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens. Antimicrob Agents Chemother (2015) 0.76
Discovery of triazine mimetics as potent antileishmanial agents. ACS Med Chem Lett (2013) 0.75
Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes. Chem Sci (2016) 0.75
Spiroindolones, a potent compound class for the treatment of malaria. Science (2010) 5.94
Identification of an antimalarial synthetic trioxolane drug development candidate. Nature (2004) 4.57
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem (2004) 4.33
Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov (2004) 3.90
Kinetoplastids: related protozoan pathogens, different diseases. J Clin Invest (2008) 3.59
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc Natl Acad Sci U S A (2011) 3.23
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci U S A (2010) 2.57
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2. J Cell Sci (2008) 2.36
ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton. Mol Biol Cell (2009) 2.10
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis (2010) 2.08
Antiparasitic compounds that target DNA. Biochimie (2008) 2.00
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryot Cell (2003) 1.94
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure. J Am Chem Soc (2005) 1.87
Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem (2010) 1.84
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrob Agents Chemother (2009) 1.73
Hemichannel and junctional properties of connexin 50. Biophys J (2002) 1.69
Plasma miRNAs Effectively Distinguish Patients With Pancreatic Cancer From Controls: A Multicenter Study. Ann Surg (2016) 1.66
Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity. Curr Med Chem Anticancer Agents (2005) 1.66
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Negl Trop Dis (2011) 1.66
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol (2006) 1.64
Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res (2002) 1.61
Biosensor-surface plasmon resonance: quantitative analysis of small molecule-nucleic acid interactions. Methods (2007) 1.58
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrob Agents Chemother (2006) 1.57
Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Mar Drugs (2010) 1.52
Therapeutic monitoring of serum digoxin for patients with heart failure using a rapid LC-MS/MS method. Clin Biochem (2009) 1.50
Synthesis and antiprotozoal activity of aza-analogues of furamidine. J Med Chem (2003) 1.49
Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop Dis (2009) 1.48
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrob Agents Chemother (2006) 1.48
Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo. Antimicrob Agents Chemother (2013) 1.47
Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother (2010) 1.45
Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PLoS One (2012) 1.45
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum. J Antimicrob Chemother (2006) 1.44
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem (2006) 1.44
DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives. J Am Chem Soc (2004) 1.44
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob Agents Chemother (2007) 1.44
Identification of an HLA-A*0201-restrictive CTL epitope from MUC4 for applicable vaccine therapy. Immunopharmacol Immunotoxicol (2009) 1.42
Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs (2010) 1.42
Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol (2008) 1.42
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure. J Am Chem Soc (2005) 1.40
Molecular basis of pH and Ca2+ regulation of aquaporin water permeability. J Gen Physiol (2004) 1.40
Pharmacokinetics and clinical utility of sodium bromide (NaBr) as an estimator of extracellular fluid volume in horses. J Vet Intern Med (2003) 1.38
Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species. Bioorg Med Chem (2002) 1.37
Imidazolopiperazines: hit to lead optimization of new antimalarial agents. J Med Chem (2011) 1.36
Soluble amyloid beta-oligomers affect dielectric membrane properties by bilayer insertion and domain formation: implications for cell toxicity. Biophys J (2008) 1.36
Discovery of dual function acridones as a new antimalarial chemotype. Nature (2009) 1.36
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes. J Med Chem (2005) 1.35
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrob Agents Chemother (2007) 1.35
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis. J Nat Prod (2004) 1.33
Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. J Biol Chem (2002) 1.33
Micro-domains of AQP0 in lens equatorial fibers. Exp Eye Res (2002) 1.32
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Surface sialic acids taken from the host allow trypanosome survival in tsetse fly vectors. J Exp Med (2004) 1.31
Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. Cancer Sci (2010) 1.31
CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. Drug Metab Dispos (2006) 1.30
Characterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major. Infect Immun (2004) 1.29
Bottlenecks and the maintenance of minor genotypes during the life cycle of Trypanosoma brucei. PLoS Pathog (2010) 1.28
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrob Agents Chemother (2011) 1.26
Antiparasitic agents: new drugs on the horizon. Curr Opin Pharmacol (2012) 1.25
Global metabolic responses of mice to Trypanosoma brucei brucei infection. Proc Natl Acad Sci U S A (2008) 1.24
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J Med Chem (2012) 1.22
Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections. J Infect Dis (2005) 1.22
Using a 3-O-sulfated heparin octasaccharide to inhibit the entry of herpes simplex virus type 1. Biochemistry (2008) 1.21
Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment. Antimicrob Agents Chemother (2010) 1.20
Determination of the substrate specificities of N-acetyl-d-glucosaminyltransferase. Biochemistry (2006) 1.18
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
Transformation of plasmid DNA into E. coli using the heat shock method. J Vis Exp (2007) 1.17
Polycyclic aromatic hydrocarbons (PAHs) in urban soils of the megacity Shanghai: occurrence, source apportionment and potential human health risk. Sci Total Environ (2013) 1.17
Predicting drug responsiveness in human cancers using genetically engineered mice. Clin Cancer Res (2013) 1.16
Structure-activity study of pentamidine analogues as antiprotozoal agents. J Med Chem (2009) 1.16
Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell (2010) 1.15
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle. J Am Chem Soc (2003) 1.15
Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes. Ecology (2009) 1.15
Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate. Acta Trop (2007) 1.15
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. J Med Chem (2005) 1.15
Side population in the pancreatic cancer cell lines SW1990 and CFPAC-1 is enriched with cancer stem-like cells. Oncol Rep (2010) 1.13
Comparative thermodynamics for monomer and dimer sequence-dependent binding of a heterocyclic dication in the DNA minor groove. J Mol Biol (2002) 1.12
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents. Chembiochem (2003) 1.12
In vivo versus in vitro airway surface liquid nicotine levels following cigarette smoke exposure. J Anal Toxicol (2008) 1.11
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution. Cancer Res (2002) 1.11
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. Bioorg Med Chem Lett (2003) 1.11