Destruction of U2, U4, or U6 small nuclear RNA blocks trans splicing in trypanosome cells.

PubWeight™: 1.89‹?› | Rank: Top 3%

🔗 View Article (PMID 1692263)

Published in Cell on May 04, 1990

Authors

C Tschudi1, E Ullu

Author Affiliations

1: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

Articles citing this

trans and cis splicing in trypanosomatids: mechanism, factors, and regulation. Eukaryot Cell (2003) 2.91

Temporal order of RNA-processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly synthesized tubulin transcripts. Mol Cell Biol (1993) 2.12

Short leader sequences may be transferred from small RNAs to pre-mature mRNAs by trans-splicing in Euglena. EMBO J (1991) 1.85

A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA. RNA (2000) 1.79

Trypanosoma brucei spliced-leader RNA methylations are required for trans splicing in vivo. Mol Cell Biol (1992) 1.52

Trans splicing in trypanosomes requires methylation of the 5' end of the spliced leader RNA. Proc Natl Acad Sci U S A (1991) 1.51

Operons and SL2 trans-splicing exist in nematodes outside the genus Caenorhabditis. Proc Natl Acad Sci U S A (1997) 1.47

Requirement of a polypyrimidine tract for trans-splicing in trypanosomes: discriminating the PARP promoter from the immediately adjacent 3' splice acceptor site. EMBO J (1991) 1.44

RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements. Mol Cell Biol (1994) 1.42

Affinity purification of Trypanosoma brucei small nuclear ribonucleoproteins reveals common and specific protein components. Proc Natl Acad Sci U S A (1991) 1.38

The pre-mRNA splicing machinery of trypanosomes: complex or simplified? Eukaryot Cell (2010) 1.30

Gene expression in Leishmania: analysis of essential 5' DNA sequences. Proc Natl Acad Sci U S A (1992) 1.27

Analysis of small nuclear ribonucleoproteins (RNPs) in Trypanosoma brucei: structural organization and protein components of the spliced leader RNP. Mol Cell Biol (1991) 1.25

The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA. RNA (2002) 1.25

Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP. EMBO J (1997) 1.25

Maturation of polycistronic pre-mRNA in Trypanosoma brucei: analysis of trans splicing and poly(A) addition at nascent RNA transcripts from the hsp70 locus. Mol Cell Biol (1991) 1.23

Exportin 1 mediates nuclear export of the kinetoplastid spliced leader RNA. Eukaryot Cell (2003) 1.22

The spliceosomal snRNP core complex of Trypanosoma brucei: cloning and functional analysis reveals seven Sm protein constituents. Proc Natl Acad Sci U S A (2000) 1.22

Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolism. RNA (2009) 1.19

Evidence for the presence of a small U5-like RNA in active trans-spliceosomes of Trypanosoma brucei. EMBO J (1996) 1.14

The U5 RNA of trypanosomes deviates from the canonical U5 RNA: the Leptomonas collosoma U5 RNA and its coding gene. Proc Natl Acad Sci U S A (1997) 1.12

Determinants for cap trimethylation of the U2 small nuclear RNA are not conserved between Trypanosoma brucei and higher eukaryotic organisms. Nucleic Acids Res (2000) 1.12

Domain structure of U2 and U4/U6 small nuclear ribonucleoprotein particles from Trypanosoma brucei: identification of trans-spliceosomal specific RNA-protein interactions. Mol Cell Biol (1992) 1.11

RNA B is the major nucleolar trimethylguanosine-capped small nuclear RNA associated with fibrillarin and pre-rRNAs in Trypanosoma brucei. Mol Cell Biol (1993) 1.11

Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype. Proc Natl Acad Sci U S A (1991) 1.07

In vivo structural analysis of spliced leader RNAs in Trypanosoma brucei and Leptomonas collosoma: a flexible structure that is independent of cap4 methylations. RNA (1995) 1.03

Cell cycle regulation of RPA1 transcript levels in the trypanosomatid Crithidia fasciculata. Nucleic Acids Res (1997) 1.03

Spliced leader RNA of trypanosomes: in vivo mutational analysis reveals extensive and distinct requirements for trans splicing and cap4 formation. EMBO J (1996) 1.03

Spliced-leader RNA silencing: a novel stress-induced mechanism in Trypanosoma brucei. EMBO Rep (2007) 1.02

The trans-spliceosomal U2 snRNP protein 40K of Trypanosoma brucei: cloning and analysis of functional domains reveals homology to a mammalian snRNP protein. EMBO J (1993) 0.97

Sequence elements in both the intergenic space and the 3' untranslated region of the Crithidia fasciculata KAP3 gene are required for cell cycle regulation of KAP3 mRNA. Eukaryot Cell (2003) 0.96

Establishment of an in vitro trans-splicing system in Trypanosoma brucei that requires endogenous spliced leader RNA. Nucleic Acids Res (2010) 0.93

Analysis of spliceosomal proteins in Trypanosomatids reveals novel functions in mRNA processing. J Biol Chem (2010) 0.92

Trypanosome spliced-leader-associated RNA (SLA1) localization and implications for spliced-leader RNA biogenesis. Eukaryot Cell (2008) 0.91

Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate. J Cell Sci (2012) 0.90

More surprises from Kinetoplastida. Proc Natl Acad Sci U S A (1999) 0.90

trans splicing of polycistronic Caenorhabditis elegans pre-mRNAs: analysis of the SL2 RNA. Mol Cell Biol (2000) 0.89

Characterization of a novel trypanosomatid small nucleolar RNA. Nucleic Acids Res (1998) 0.86

Two splicing factors carrying serine-arginine motifs, TSR1 and TSR1IP, regulate splicing, mRNA stability, and rRNA processing in Trypanosoma brucei. RNA Biol (2014) 0.83

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei. Cell Res (2013) 0.82

Structure-function analysis of the trypanosomatid spliced leader RNA. Nucleic Acids Res (1998) 0.80

A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila. Genes Dev (2015) 0.79

snRNA-specific role of SMN in trypanosome snRNP biogenesis in vivo. RNA Biol (2011) 0.79

The role played by alternative splicing in antigenic variability in human endo-parasites. Parasit Vectors (2014) 0.78

The spliceosomal PRP19 complex of trypanosomes. Mol Microbiol (2015) 0.76

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes. BMC Genomics (2016) 0.75

Articles by these authors

Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc Natl Acad Sci U S A (1998) 5.28

Alu sequences are processed 7SL RNA genes. Nature (1984) 4.67

Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an alu sequence. Cell (1982) 3.74

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. Genes Dev (1994) 3.21

Upstream sequences modulate the internal promoter of the human 7SL RNA gene. Nature (1985) 2.97

RNA interference in Trypanosoma brucei: cloning of small interfering RNAs provides evidence for retroposon-derived 24-26-nucleotide RNAs. RNA (2001) 2.61

Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA. RNA (2000) 2.33

Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J (1984) 2.05

Polygene transcripts are precursors to calmodulin mRNAs in trypanosomes. EMBO J (1988) 1.98

A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA. RNA (2000) 1.79

MFR, a putative receptor mediating the fusion of macrophages. Mol Cell Biol (1998) 1.64

The U2 RNA analogue of Trypanosoma brucei gambiense: implications for a splicing mechanism in trypanosomes. Nucleic Acids Res (1986) 1.57

Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in trypanosomes. Mol Cell Biol (1994) 1.44

Import of proteins into the trypanosome nucleus and their distribution at karyokinesis. J Cell Sci (2000) 1.40

Transcription of the Trypanosoma brucei spliced leader RNA gene is dependent only on the presence of upstream regulatory elements. Mol Biochem Parasitol (1997) 1.40

Identification of dynamic sequences in the central domain of 7SL RNA. Nucleic Acids Res (1986) 1.38

DNA sequences complementary to human 7 SK RNA show structural similarities to the short mobile elements of the mammalian genome. J Mol Biol (1984) 1.37

In vivo epitope tagging of Trypanosoma brucei genes using a one step PCR-based strategy. Mol Biochem Parasitol (2001) 1.37

Cotranscriptional cap 4 formation on the Trypanosoma brucei spliced leader RNA. J Biol Chem (2000) 1.29

Identification and isolation of a major cell surface glycoprotein of Pneumocystis carinii. Infect Immun (1989) 1.28

Evolutionary conservation of the human 7 S RNA sequences. J Mol Biol (1982) 1.22

Exonic sequences in the 5' untranslated region of alpha-tubulin mRNA modulate trans splicing in Trypanosoma brucei. Mol Cell Biol (1998) 1.17

Construction of a recombinant bacterial plasmid containing DNA sequences for a mouse embryonic globin chain. Nucleic Acids Res (1979) 1.17

The 7SL RNA homologue of Trypanosoma brucei is closely related to mammalian 7SL RNA. Mol Biochem Parasitol (1992) 1.15

Cloning and characterization of cDNA copies of the 7S RNAs of HeLa cells. Nucleic Acids Res (1982) 1.14

The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Res (1988) 1.14

Determinants for cap trimethylation of the U2 small nuclear RNA are not conserved between Trypanosoma brucei and higher eukaryotic organisms. Nucleic Acids Res (2000) 1.12

Structure of the Trypanosoma brucei U6 snRNA gene promoter. Mol Biochem Parasitol (1997) 1.05

Accurate transcription of the Trypanosoma brucei U2 small nuclear RNA gene in a homologous extract. J Biol Chem (1995) 1.04

In vivo structural analysis of spliced leader RNAs in Trypanosoma brucei and Leptomonas collosoma: a flexible structure that is independent of cap4 methylations. RNA (1995) 1.03

Trypanosome capping enzymes display a novel two-domain structure. Mol Cell Biol (1998) 1.02

Identification of a tRNA-like molecule that copurifies with the 7SL RNA of Trypanosoma brucei. Mol Biochem Parasitol (1993) 1.01

Physical and transcriptional analysis of the Trypanosoma brucei genome reveals a typical eukaryotic arrangement with close interspersionof RNA polymerase II- and III-transcribed genes. Nucleic Acids Res (1998) 0.96

Conserved sequences in the U2 snRNA-encoding genes of Kinetoplastida do not include the putative branchpoint recognition region. Gene (1990) 0.96

Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Mol Biochem Parasitol (2001) 0.90

Differences in glucose transport between blood stream and procyclic forms of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol (1991) 0.90

Organization of DNA and RNA from rat Pneumocystis carinii. J Protozool (1989) 0.84

Control of gene expression during the terminal differentiation of erythroid cells. Curr Top Dev Biol (1975) 0.82

Isolation and characterization of the messenger RNAs for mouse embryonic globin chains. Eur J Biochem (1978) 0.79

Unusual diversity in alpha-amanitin sensitivity of RNA polymerases in trichomonads. Mol Biochem Parasitol (2001) 0.79

Trypanosomatid protozoa provide paradigms of eukaryotic biology. Infect Agents Dis (1994) 0.79

Disappearance of a 32000 D chromatin polypeptide during early erythroid differentiation of Friend leukemia cells. Exp Cell Res (1978) 0.77

Nuclear RNA sequences coding for alpha and beta globins in erythroid cells: evidence for multiple intermediate molecules. Blood (1979) 0.77

Polyribosomal structures inactive for protein synthesis present in erythroid cells during terminal stages of differentiation. Cell Differ (1975) 0.75

Terminal stages of erythroid differentiation: persistent production of globin messenger RNA is necessary to sustain globin synthesis. Blood (1978) 0.75

Terminal erythroid differentiation of yolk sac erythroid cells. A 35,000 dalton non-histone protein is selectively maintained in condensed chromatin. Basic Appl Histochem (1982) 0.75

Mouse foetal development: translational inactivation of globin genes during the terminal differentiation of yolk sac erythroid cells. Ann Immunol (Paris) (1977) 0.75

Mouse satellite DNA isolated by Ag+ -- CsSO4 density gradients contains G+C rich, slow reassociating sequences. Biochem Exp Biol (1977) 0.75