Human hepatocyte transplantation: worldwide results.

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med (2010) 7.11

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology (2010) 6.40

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91

Rescue of lethal hepatic failure by hepatized lymph nodes in mice. Gastroenterology (2010) 2.02

Therapeutic liver reconstitution with murine cells isolated long after death. Gastroenterology (2010) 1.78

Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest (2010) 1.66

Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol (2010) 1.52

Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure. PLoS One (2014) 1.50

Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc (2013) 1.44

Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int (2010) 1.33

The mouse lymph node as an ectopic transplantation site for multiple tissues. Nat Biotechnol (2012) 1.27

Macroscale delivery systems for molecular and cellular payloads. Nat Mater (2013) 1.25

Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol (2009) 1.18

Cell delivery: from cell transplantation to organ engineering. Cell Transplant (2010) 1.06

Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model. PLoS One (2008) 1.01

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS One (2010) 0.99

Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Am J Pathol (2010) 0.96

Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit? Transplantation (2009) 0.95

Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells. Int J Biochem Cell Biol (2010) 0.94

Regenerative medicine as applied to general surgery. Ann Surg (2012) 0.92

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res (2013) 0.92

Foetal hepatocyte transplantation in a vascularized AV-Loop transplantation model in the rat. J Cell Mol Med (2008) 0.91

Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes. Hepatology (2013) 0.91

Human pluripotent stem cells for modelling human liver diseases and cell therapy. Curr Gene Ther (2013) 0.90

Placental stem cell correction of murine intermediate maple syrup urine disease. Hepatology (2013) 0.89

Bioengineering in organ transplantation: targeting the liver. Transplant Proc (2011) 0.89

Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice. Hepatology (2009) 0.88

Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats. Int J Mol Med (2014) 0.86

Cellular therapy and bioartificial approaches to liver replacement. Curr Opin Organ Transplant (2012) 0.86

Single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in Gunn rats. PLoS One (2012) 0.86

Spontaneous origin from human embryonic stem cells of liver cells displaying conjoint meso-endodermal phenotype with hepatic functions. J Cell Sci (2012) 0.85

Biosafety in ex vivo gene therapy and conditional ablation of lentivirally transduced hepatocytes in nonhuman primates. Mol Ther (2009) 0.85

SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell Med (2013) 0.84

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease. Stem Cell Res (2014) 0.84

Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes. Stem Cell Reports (2015) 0.84

Monitoring of Liver Cell Transplantation in a Preclinical Swine Model Using Magnetic Resonance Imaging. Cell Med (2010) 0.84

Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury. Int J Mol Sci (2014) 0.84

CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells. Biomed Opt Express (2011) 0.83

Clinical applications of hepatocyte transplantation. World J Gastroenterol (2009) 0.83

Proceedings: moving toward cell-based therapies for liver disease. Stem Cells Transl Med (2015) 0.83

Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World J Gastroenterol (2013) 0.82

Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats. Hepatology (2012) 0.82

Imaging of primary human hepatocytes performed with micron-sized iron oxide particles and clinical magnetic resonance tomography. J Cell Mol Med (2008) 0.82

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients. Curr Protoc Toxicol (2014) 0.81

New directions for cell-based therapies in acute liver failure. J Hepatol (2012) 0.81

A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol (2009) 0.80

How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology? World J Gastroenterol (2012) 0.80

From skin cells to hepatocytes: advances in application of iPS cell technology. J Clin Invest (2010) 0.79

Hepatocyte transplantation program: Lessons learned and future strategies. World J Gastroenterol (2016) 0.78

Rodent animal models for surrogate analysis of cell therapy in acute liver failure. Front Physiol (2012) 0.78

Injury-dependent retention of intraportally administered mesenchymal stromal cells following partial hepatectomy of steatotic liver does not lead to improved liver recovery. PLoS One (2013) 0.78

Liver cell transplantation for the treatment of inborn errors of metabolism. J Inherit Metab Dis (2008) 0.78

Liver transplantation in glycogen storage disease type I. Orphanet J Rare Dis (2014) 0.78

New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases. Curr Transplant Rep (2015) 0.77

Hepatocyte transplantation. J Clin Exp Hepatol (2011) 0.77

Treatment of acute liver failure in mice by hepatocyte xenotransplantation. Cell Transplant (2010) 0.77

Embryonic and induced pluripotent stem cells as a model for liver disease. Crit Rev Biomed Eng (2009) 0.77

Experimental hepatocyte xenotransplantation--a comprehensive review of the literature. Xenotransplantation (2015) 0.77

Biomaterials as carrier, barrier and reactor for cell-based regenerative medicine. Protein Cell (2015) 0.76

Hepatic differentiation of murine disease-specific induced pluripotent stem cells allows disease modelling in vitro. Stem Cells Int (2011) 0.76

Consideration of a Safe Protocol for Hepatocyte Transplantation Using Infantile Pigs. Cell Med (2012) 0.75

Immunological aspects of liver cell transplantation. World J Transplant (2016) 0.75

Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture. Sci Rep (2017) 0.75

Hepatocyte Transplantation in Special Populations: Clinical Use in Children. Methods Mol Biol (2017) 0.75

Living donor liver transplantation for neonatal hemochromatosis using non-anatomically resected segments II and III: a case report. J Med Case Rep (2010) 0.75

Microporous membrane-based liver tissue engineering for the reconstruction of three-dimensional functional liver tissues in vitro. Biomatter (2013) 0.75

Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition. Sci Rep (2016) 0.75

Stem cell-based therapy for α₁-antitrypsin deficiency. Stem Cell Res Ther (2012) 0.75

Transdifferentiation of human male germline stem cells to hepatocytes in vivo via the transplantation under renal capsules. Oncotarget (2017) 0.75

Improvement of Infusion Process in Cell Transplantation: Effect of Shear Stress on Hepatocyte Viability Under Horizontal and Vertical Syringe Orientation. Cell Med (2014) 0.75

Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation. Curr Transplant Rep (2017) 0.75

Effects of octenidine HCl on liver tissue: could it be an alternative scolicidal for Hidatid disease? World J Surg (2007) 0.75

Proposal of a novel evaluation index for the effects of shear stress and exposure time on hepatocyte damage. J Artif Organs (2015) 0.75

The Optimization of Short-Term Hepatocyte Preservation Before Transplantation. Transplant Direct (2017) 0.75

Biological and clinical insights offered by chemically induced liver progenitors (CLiPs). Stem Cell Investig (2017) 0.75

Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99

Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells (2007) 3.39

Stem cell characteristics of amniotic epithelial cells. Stem Cells (2005) 2.66

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06

A whole-organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods (2011) 1.60

Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels. Tissue Eng Part A (2010) 1.50

Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics (2003) 1.49

Amnion-derived pluripotent/multipotent stem cells. Stem Cell Rev (2006) 1.48

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol (2007) 1.46

Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol (2010) 1.41

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry (2010) 1.32

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant (2012) 1.31

Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2011) 1.30

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol (2007) 1.29

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos (2004) 1.19

Human hepatocyte transplantation. Methods Mol Biol (2010) 1.17

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation. Cell Transplant (2011) 1.16

Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol Pharmacol (2005) 1.14

Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1. Cell Transplant (2005) 1.12

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol Sci (2003) 1.08

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes (2012) 1.08

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. J Pharmacol Exp Ther (2007) 1.07

Identification of stem cell marker-positive cells by immunofluorescence in term human amnion. J Reprod Immunol (2007) 1.06

MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation. Mol Endocrinol (2011) 1.05

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes. Drug Metab Dispos (2002) 1.04

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci (2010) 1.03

Isolation of amniotic epithelial stem cells. Curr Protoc Stem Cell Biol (2010) 1.03

Side population cells derived from adult human liver generate hepatocyte-like cells in vitro. Dig Dis Sci (2005) 1.02

Hepatic differentiation of amniotic epithelial cells. Hepatology (2011) 0.99

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone. Toxicol Sci (2006) 0.99

Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors. Am J Pathol (2005) 0.97

Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Mol Ther (2009) 0.96

A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I. Eur J Biochem (2003) 0.96

Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicol Appl Pharmacol (2008) 0.96

Production of hepatocyte-like cells from human amnion. Methods Mol Biol (2009) 0.95

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes. Toxicol Sci (2005) 0.94

Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochim Biophys Acta (2009) 0.94

Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes. Drug Metab Dispos (2010) 0.93

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res (2013) 0.92

Isolation of amniotic mesenchymal stem cells. Curr Protoc Stem Cell Biol (2010) 0.92

The second extracellular loop dictates Occludin-mediated HCV entry. Virology (2010) 0.92

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Mol Pharmacol (2005) 0.92

Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos (2002) 0.91

In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant (2003) 0.89

Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures. Clin Cancer Res (2005) 0.89

Placental stem cell correction of murine intermediate maple syrup urine disease. Hepatology (2013) 0.89

Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice. Mol Genet Metab (2013) 0.88

Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact (2008) 0.87

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes. Drug Metab Dispos (2012) 0.85

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s. Drug Metab Dispos (2013) 0.85

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. Drug Metab Dispos (2005) 0.84

Clinical hepatocyte transplantation: practical limits and possible solutions. Eur Surg Res (2015) 0.84

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases. Mol Endocrinol (2012) 0.84

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes. Pharmacogenet Genomics (2006) 0.84

FoxO1 links hepatic insulin action to endoplasmic reticulum stress. Endocrinology (2010) 0.84

To be or not to be: generation of hepatocytes from cells outside the liver. Gastroenterology (2008) 0.84

Naive rat amnion-derived cell transplantation improved left ventricular function and reduced myocardial scar of postinfarcted heart. Cell Transplant (2009) 0.83

Mice with chimeric livers are an improved model for human lipoprotein metabolism. PLoS One (2013) 0.83

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. Clin Immunol (2010) 0.83

ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes. Pediatr Res (2010) 0.83

Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition. Drug Metab Dispos (2009) 0.82

Hypothermic storage of human hepatocytes for transplantation. Cell Transplant (2014) 0.81

Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites. Chem Res Toxicol (2007) 0.81

Rapid and sensitive assessment of human hepatocyte functions. Cell Transplant (2014) 0.81

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer. Drug Metab Dispos (2013) 0.81

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. Biochem Pharmacol (2007) 0.81

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients. Curr Protoc Toxicol (2014) 0.81

Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B. Clin Exp Pharmacol Physiol (2007) 0.80

Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis. Hepatology (2011) 0.80

Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Res (2007) 0.80

Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats. Drug Metab Dispos (2004) 0.79

Potential barriers to human hepatocyte transplantation in MUP-uPAtg(⁺/⁺)Rag2⁻/⁻γC⁻/⁻ mice. Cell Transplant (2013) 0.79

Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicol Sci (2009) 0.79

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS. J Pharm Biomed Anal (2012) 0.79

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Mol Pharmacol (2012) 0.79

Bigger may not be better when it comes to hepatocytes. Liver Transpl (2006) 0.79

Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metab Dispos (2009) 0.78

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals. ALTEX (2009) 0.78

Why do most human liver cytosol preparations lack xanthine oxidase activity? Drug Metab Dispos (2014) 0.77

Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Pharm Res (2005) 0.77

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J Biol Chem (2014) 0.77

Embryonic and induced pluripotent stem cells as a model for liver disease. Crit Rev Biomed Eng (2009) 0.77

Effects of green tea compounds on irinotecan metabolism. Drug Metab Dispos (2006) 0.76

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions. Cell Transplant (2013) 0.76

Regulation of the human cathepsin E gene by the constitutive androstane receptor. Arch Biochem Biophys (2007) 0.76

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol (2012) 0.75