Published in Toxicol Sci on January 12, 2006
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol (2007) 5.04
Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metab Rev (2010) 1.52
Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance. Comb Chem High Throughput Screen (2010) 1.18
In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats. Drug Metab Dispos (2010) 0.98
Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. Front Pharmacol (2014) 0.93
Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport. Toxicol In Vitro (2009) 0.87
A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Aust N Z J Psychiatry (2011) 0.84
Plasma bile acid concentrations in patients with human immunodeficiency virus infection receiving protease inhibitor therapy: possible implications for hepatotoxicity. Pharmacotherapy (2010) 0.82
Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters. Acta Pharmacol Sin (2014) 0.78
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Arch Toxicol (2016) 0.77
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. Arch Toxicol (2016) 0.75
Fasiglifam (TAK-875) alters bile acid homeostasis in rats and dogs: a potential cause of drug induced liver injury. Toxicol Sci (2017) 0.75
Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology (2008) 3.99
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells. Stem Cells (2007) 3.39
Human hepatocyte transplantation: worldwide results. Transplantation (2006) 3.02
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Stem cell characteristics of amniotic epithelial cells. Stem Cells (2005) 2.66
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions. Pharm Res (2012) 2.18
Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril (2002) 2.10
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res (2010) 2.06
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nat Chem Biol (2011) 1.82
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem (2003) 1.69
A whole-organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods (2011) 1.60
Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States. Chem Res Toxicol (2011) 1.54
Calcium precursors for the production of CaO sorbents for multicycle CO2 capture. Environ Sci Technol (2010) 1.52
Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels. Tissue Eng Part A (2010) 1.50
Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics (2003) 1.49
Amnion-derived pluripotent/multipotent stem cells. Stem Cell Rev (2006) 1.48
A comprehensive listing of bioactivation pathways of organic functional groups. Curr Drug Metab (2005) 1.47
Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol (2007) 1.46
Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines. Ann Surg Oncol (2011) 1.41
Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol (2010) 1.41
Laparoscopic treatment for small intestinal bleeding: a report of 77 cases. J Laparoendosc Adv Surg Tech A (2010) 1.38
Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Res (2014) 1.34
The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry (2010) 1.32
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant (2012) 1.31
Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2011) 1.30
Chinese patent medicine liu wei di huang wan combined with antihypertensive drugs, a new integrative medicine therapy, for the treatment of essential hypertension: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med (2012) 1.29
Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol (2007) 1.29
Laparoscopic versus open right hemicolectomy with curative intent for colon carcinoma. World J Gastroenterol (2005) 1.28
Demystifying brain penetration in central nervous system drug discovery. Miniperspective. J Med Chem (2012) 1.28
Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol Res (2009) 1.25
Biotransformation reactions of five-membered aromatic heterocyclic rings. Chem Res Toxicol (2002) 1.22
Development of a new permeability assay using low-efflux MDCKII cells. J Pharm Sci (2011) 1.21
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J Med Chem (2012) 1.19
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos (2004) 1.19
Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res (2011) 1.18
Human hepatocyte transplantation. Methods Mol Biol (2010) 1.17
Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation. Cell Transplant (2011) 1.16
Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol Pharmacol (2005) 1.14
A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev (2013) 1.13
Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1. Cell Transplant (2005) 1.12
Physicochemical determinants of human renal clearance. J Med Chem (2009) 1.11
Oncological superiority of extralevator abdominoperineal resection over conventional abdominoperineal resection: a meta-analysis. Int J Colorectal Dis (2014) 1.10
ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes (2012) 1.08
The role of bias in crystallization conditions in automated microseeding. Acta Crystallogr D Biol Crystallogr (2008) 1.08
Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats. Toxicol Sci (2003) 1.08
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. Environ Health Perspect (2010) 1.07
Brain-derived neurotrophic factor: a novel human ovarian follicular protein. J Clin Endocrinol Metab (2002) 1.07
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor. J Pharmacol Exp Ther (2007) 1.07
Direct proof of the tree-level scattering amplitude recursion relation in Yang-mills theory. Phys Rev Lett (2005) 1.06
Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity. Chem Res Toxicol (2006) 1.06
Identification of stem cell marker-positive cells by immunofluorescence in term human amnion. J Reprod Immunol (2007) 1.06
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance(). Medchemcomm (2012) 1.05
MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation. Mol Endocrinol (2011) 1.05
Metabonomics identifies serum metabolite markers of colorectal cancer. J Proteome Res (2013) 1.05
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos (2012) 1.04
Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes. Drug Metab Dispos (2002) 1.04
Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci (2010) 1.03
Isolation of amniotic epithelial stem cells. Curr Protoc Stem Cell Biol (2010) 1.03
Wide distribution among halophilic archaea of a novel polyhydroxyalkanoate synthase subtype with homology to bacterial type III synthases. Appl Environ Microbiol (2010) 1.02
Side population cells derived from adult human liver generate hepatocyte-like cells in vitro. Dig Dis Sci (2005) 1.02
Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study. Brain Res (2011) 1.02
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells. Med Sci Monit (2012) 1.01
A fluorescent rosamine compound selectively stains pluripotent stem cells. Angew Chem Int Ed Engl (2010) 1.01
miR-320a suppresses colorectal cancer progression by targeting Rac1. Carcinogenesis (2013) 1.01
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. J Med Chem (2012) 1.01
A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells (2013) 1.01
Hepatic differentiation of amniotic epithelial cells. Hepatology (2011) 0.99
The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice. Drug Metab Dispos (2009) 0.99
P2Y1 receptor antagonists as novel antithrombotic agents. Bioorg Med Chem Lett (2008) 0.99
Banxia baizhu tianma decoction for essential hypertension: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med (2012) 0.98
Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol (2003) 0.97
Is yangxue qingnao granule combined with antihypertensive drugs, a new integrative medicine therapy, more effective than antihypertensive therapy alone in treating essential hypertension? Evid Based Complement Alternat Med (2013) 0.97
Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors. Am J Pathol (2005) 0.97
Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement. Drug Metab Dispos (2012) 0.96
Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia. PLoS One (2013) 0.96
Laparoscopic gastric resection approaches for gastrointestinal stromal tumors of stomach. Surg Laparosc Endosc Percutan Tech (2011) 0.96
A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I. Eur J Biochem (2003) 0.96
Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Mol Ther (2009) 0.96
Simultaneous laparoscopy-assisted low anterior resection and distal gastrectomy for synchronous carcinoma of rectum and stomach. World J Gastroenterol (2008) 0.96
Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci (2009) 0.96
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicol Appl Pharmacol (2008) 0.96
P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. Int J Oncol (2010) 0.95
The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. PLoS One (2013) 0.95
Tianma gouteng yin as adjunctive treatment for essential hypertension: a systematic review of randomized controlled trials. Evid Based Complement Alternat Med (2013) 0.95
Production of hepatocyte-like cells from human amnion. Methods Mol Biol (2009) 0.95
Immunocytochemical evidence for the presence and location of the neurotrophin-Trk receptor family in adult human preovulatory ovarian follicles. Am J Obstet Gynecol (2006) 0.95
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem Res Toxicol (2008) 0.95
Effect of chlorpyrifos on soil microbial populations and enzyme activities. J Environ Sci (China) (2006) 0.95
Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes. Toxicol Sci (2005) 0.94