PubRank

M Lienhard Schmitz

Author PubWeight™ 60.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 2002 3.24
2 Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem 2004 2.38
3 Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem 2004 2.29
4 SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell 2010 1.79
5 A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell 2012 1.73
6 Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J Immunol 2004 1.69
7 Autoregulatory feedback loops terminating the NF-kappaB response. Trends Biochem Sci 2009 1.46
8 Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell 2006 1.37
9 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J 2006 1.37
10 NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem 2007 1.34
11 HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle 2007 1.34
12 HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 2003 1.32
13 An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 2008 1.29
14 Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. J Biol Chem 2006 1.28
15 Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J 2002 1.24
16 Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon. Nucleic Acids Res 2010 1.20
17 PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res 2003 1.19
18 The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J 2002 1.12
19 The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex. J Biol Chem 2002 1.11
20 Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J 2006 1.10
21 Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation. J Immunol 2003 1.06
22 IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine 2005 1.04
23 HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. J Mol Cell Biol 2012 1.02
24 The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem 2006 0.98
25 The NF-kappaB pathway as a potential target for autoimmune disease therapy. Curr Pharm Des 2004 0.95
26 Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB. J Biol Chem 2007 0.95
27 Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One 2012 0.93
28 Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol 2007 0.93
29 Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells. J Cell Biochem 2007 0.92
30 Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability. Biochem Biophys Res Commun 2005 0.92
31 Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}. J Biol Chem 2005 0.91
32 Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem 2006 0.90
33 The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res 2012 0.90
34 Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Blood 2004 0.89
35 Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis. J Immunol 2002 0.89
36 From top to bottom: the two faces of HIPK2 for regulation of the hypoxic response. Cell Cycle 2009 0.89
37 Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene 2003 0.89
38 Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta 2010 0.87
39 Lipoteichoic acid selectively induces the ERK signaling pathway in the cornea. Invest Ophthalmol Vis Sci 2002 0.85
40 Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. J Mol Cell Biol 2012 0.85
41 The promoter context determines mutual repression or synergism between NF-kappaB and the glucocorticoid receptor. Biol Chem 2002 0.84
42 NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. Biochem Biophys Res Commun 2008 0.84
43 Viruses as hijackers of PML nuclear bodies. Arch Immunol Ther Exp (Warsz) 2003 0.83
44 Posttranslational modifications regulate HIPK2, a driver of proliferative diseases. J Mol Med (Berl) 2013 0.83
45 Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine. Chemistry 2005 0.83
46 Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing. Thromb Haemost 2014 0.82
47 T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol. Eur J Immunol 2005 0.82
48 Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage. Nucleic Acids Res 2013 0.81
49 Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS One 2013 0.80
50 Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus. Biochim Biophys Acta 2005 0.79
51 SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation. Biochim Biophys Acta 2012 0.79
52 Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation. Biol Chem 2009 0.78
53 The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. J Mol Biol 2007 0.77
54 Of mice and men. EMBO Rep 2004 0.76
55 K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell 2016 0.75