Published in J Cell Biochem on March 01, 2007
UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53. Mol Biol Cell (2008) 1.26
Updates on HIPK2: a resourceful oncosuppressor for clearing cancer. J Exp Clin Cancer Res (2012) 1.10
Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation. J Biol Chem (2009) 1.08
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS One (2009) 1.08
MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells. Oncotarget (2015) 0.86
Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation. J Pharmacol Exp Ther (2011) 0.86
Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. J Proteome Res (2007) 0.84
Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. Mol Biol Cell (2010) 0.82
Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. PLoS One (2012) 0.77
Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer. BMC Cancer (2014) 0.77
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol (2002) 3.24
Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J Biol Chem (2004) 2.29
SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell (2010) 1.79
A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell (2012) 1.73
Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import. J Immunol (2004) 1.69
Autoregulatory feedback loops terminating the NF-kappaB response. Trends Biochem Sci (2009) 1.46
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell (2006) 1.37
Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J (2006) 1.37
NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem (2007) 1.34
HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle (2007) 1.34
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res (2003) 1.32
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol (2008) 1.29
Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. J Biol Chem (2006) 1.28
Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J (2002) 1.24
Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon. Nucleic Acids Res (2010) 1.20
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res (2003) 1.19
The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J (2002) 1.12
The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex. J Biol Chem (2002) 1.11
Antinuclear antibodies in primary biliary cirrhosis. Semin Liver Dis (2005) 1.10
Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J (2006) 1.10
IL-17 reduces TNF-induced Rantes and VCAM-1 expression. Cytokine (2005) 1.04
HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. J Mol Cell Biol (2012) 1.02
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem (2006) 0.98
Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB. J Biol Chem (2007) 0.95
The NF-kappaB pathway as a potential target for autoimmune disease therapy. Curr Pharm Des (2004) 0.95
Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol (2007) 0.93
Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One (2012) 0.93
Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability. Biochem Biophys Res Commun (2005) 0.92
Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}. J Biol Chem (2005) 0.91
Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem (2006) 0.90
The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res (2012) 0.90
Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis. J Immunol (2002) 0.89
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. Oncogene (2003) 0.89
From top to bottom: the two faces of HIPK2 for regulation of the hypoxic response. Cell Cycle (2009) 0.89
Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Blood (2004) 0.89
The ceramide-enriched trans-Golgi compartments reorganize together with other parts of the Golgi apparatus in response to ATP-depletion. Histochem Cell Biol (2011) 0.89
Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta (2010) 0.87
Lipoteichoic acid selectively induces the ERK signaling pathway in the cornea. Invest Ophthalmol Vis Sci (2002) 0.85
Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways. J Mol Cell Biol (2012) 0.85
A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death. J Cell Biochem (2005) 0.84
Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine. Cell Mol Biol Lett (2007) 0.84
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. Biochem Biophys Res Commun (2008) 0.84
The promoter context determines mutual repression or synergism between NF-kappaB and the glucocorticoid receptor. Biol Chem (2002) 0.84
Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicine. Chemistry (2005) 0.83
Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen. J Cell Biochem (2008) 0.83
Characterization of autoantibodies against components of the nuclear pore complexes: high frequency of anti-p62 nucleoporin antibodies. Ann N Y Acad Sci (2007) 0.83
Viruses as hijackers of PML nuclear bodies. Arch Immunol Ther Exp (Warsz) (2003) 0.83
Posttranslational modifications regulate HIPK2, a driver of proliferative diseases. J Mol Med (Berl) (2013) 0.83
Thrombin selectively induces transcription of genes in human monocytes involved in inflammation and wound healing. Thromb Haemost (2014) 0.82
T cell receptor-induced lipid raft recruitment of the I kappa B kinase complex is necessary and sufficient for NF-kappa B activation occurring in the cytosol. Eur J Immunol (2005) 0.82
Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage. Nucleic Acids Res (2013) 0.81
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS One (2013) 0.80
SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation. Biochim Biophys Acta (2012) 0.79
Inhibition of NF-kappaB activation and expression of inflammatory mediators by polyacetylene spiroketals from Plagius flosculosus. Biochim Biophys Acta (2005) 0.79
Photooxidation technology for correlative light and electron microscopy. Methods Mol Biol (2013) 0.78
Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation. Biol Chem (2009) 0.78
Phenol red reduces ROSC mediated cell cycle arrest and apoptosis in human MCF-7 cells. J Cell Biochem (2006) 0.78
A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein. J Cell Biochem (2007) 0.77
The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. J Mol Biol (2007) 0.77
Of mice and men. EMBO Rep (2004) 0.76
Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells. Ann N Y Acad Sci (2007) 0.76
K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell (2016) 0.75