Published in Biochem J on January 01, 2007
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Mol Cell Biol (2008) 1.43
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol (2008) 1.29
The ubiquitin ligase Siah2 and the hypoxia response. Mol Cancer Res (2009) 1.29
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res (2007) 1.22
Inhibition of Siah ubiquitin ligase function. Oncogene (2008) 1.20
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem (2009) 1.08
BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression. Br J Cancer (2009) 1.05
Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PLoS One (2010) 0.96
von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas. Clin Cancer Res (2010) 0.95
The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes. Endocrinology (2012) 0.92
EGLN3 inhibition of NF-κB is mediated by prolyl hydroxylase-independent inhibition of IκB kinase γ ubiquitination. Mol Cell Biol (2013) 0.83
Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet (2014) 0.83
Seven in absentia homolog 2 (Siah2) protein is a regulator of NF-E2-related factor 2 (Nrf2). J Biol Chem (2013) 0.81
Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein. Hypoxia (Auckl) (2013) 0.79
Molecular mechanisms of action and therapeutic uses of pharmacological inhibitors of HIF-prolyl 4-hydroxylases for treatment of ischemic diseases. Antioxid Redox Signal (2013) 0.78
Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity. PLoS One (2014) 0.76
Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish. Sci Rep (2016) 0.75
Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism. Hypoxia (Auckl) (2014) 0.75
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Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (2001) 23.83
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell (2001) 19.75
A conserved family of prolyl-4-hydroxylases that modify HIF. Science (2001) 11.50
Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J (2003) 6.44
Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet (2004) 5.47
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem (2004) 5.05
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell (2001) 4.62
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci U S A (2002) 4.03
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem (2003) 3.88
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell (2004) 3.77
PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell (1997) 2.50
Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell (1997) 2.43
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol (2002) 2.32
Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes Dev (1998) 2.24
p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J (1998) 1.99
Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J (2002) 1.44
Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem Biophys Res Commun (2003) 1.40
Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev (2001) 1.30
Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex. J Biol Chem (2005) 1.23
Determination and comparison of specific activity of the HIF-prolyl hydroxylases. FEBS Lett (2004) 1.23
SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene (2000) 1.15
MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding. J Biol Chem (2001) 1.01
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J Biol Chem (2005) 0.96
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. FEBS Lett (2004) 0.94
An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity. Cancer Lett (2005) 0.88
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell (2004) 3.77
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature (2002) 3.02
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J (2004) 2.50
The cullin protein family. Genome Biol (2011) 2.43
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell (2004) 2.43
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther (2004) 2.25
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
Identification of mutations in CUL7 in 3-M syndrome. Nat Genet (2005) 2.10
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J (2002) 2.07
Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell (2007) 2.03
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail. Proc Natl Acad Sci U S A (2008) 1.92
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem (2002) 1.92
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. Proc Natl Acad Sci U S A (2002) 1.89
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species. EMBO J (2007) 1.86
Emerging roles of ATF2 and the dynamic AP1 network in cancer. Nat Rev Cancer (2010) 1.76
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol (2003) 1.75
A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. J Proteome Res (2008) 1.74
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell (2008) 1.73
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72
Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem (2003) 1.62
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J Biol Chem (2007) 1.61
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. Mol Cell (2010) 1.61
RACK1 mediates activation of JNK by protein kinase C [corrected]. Mol Cell (2005) 1.59
Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. Cell Cycle (2011) 1.59
The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. J Biol Chem (2001) 1.59
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Proc Natl Acad Sci U S A (2007) 1.58
ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis. Oncogene (2003) 1.57
The novel human DNA helicase hFBH1 is an F-box protein. J Biol Chem (2002) 1.53
Death receptors and melanoma resistance to apoptosis. Oncogene (2003) 1.51
Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity. Proc Natl Acad Sci U S A (2004) 1.46
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep (2009) 1.44
Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J (2002) 1.44
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
p53-Mdm2--the affair that never ends. Carcinogenesis (2002) 1.40
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell (2005) 1.39
An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis. J Clin Invest (2002) 1.35
Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Res (2003) 1.31
The ubiquitin ligase Siah2 and the hypoxia response. Mol Cancer Res (2009) 1.29
Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol (2005) 1.28
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. Org Biomol Chem (2004) 1.27
RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth. Mol Cell Biol (2006) 1.27
ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle (2008) 1.27
Regulation of p53 localization and activity by Ubc13. Mol Cell Biol (2006) 1.26
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proc Natl Acad Sci U S A (2008) 1.26
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function. J Biol Chem (2008) 1.24
FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface. Mol Cell Biol (2003) 1.20
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J Proteome Res (2008) 1.20
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans. Genes Dev (2004) 1.20
Proximity-induced activation of human Cdc34 through heterologous dimerization. Proc Natl Acad Sci U S A (2005) 1.19
Ubiquitin chains in the ladder of MAPK signaling. Sci STKE (2005) 1.17
Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains. Mol Cell Biol (2007) 1.15
Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends Biochem Sci (2006) 1.15
The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans. J Cell Biol (2004) 1.14
Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation. Nat Cell Biol (2006) 1.12
ATF2 on the double - activating transcription factor and DNA damage response protein. Pigment Cell Res (2007) 1.12
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J Biol Chem (2006) 1.11
Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J Biol Chem (2004) 1.11
Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. Oncogene (2004) 1.10
Understanding signaling cascades in melanoma. Photochem Photobiol (2007) 1.10
Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint. Immunity (2006) 1.08
Emerging roles of E3 ubiquitin ligases in autophagy. Trends Biochem Sci (2013) 1.07
Functional specialization in proline biosynthesis of melanoma. PLoS One (2012) 1.06
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J Biol Chem (2004) 1.05
Inhibition of melanoma growth and metastasis by ATF2-derived peptides. Cancer Res (2004) 1.05
The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. PLoS One (2008) 1.05
Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah. J Biol Chem (2004) 1.04
Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem (2001) 1.04
Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis. J Biol Chem (2005) 1.02
Selective recruitment of an E2~ubiquitin complex by an E3 ubiquitin ligase. J Biol Chem (2012) 1.02
SUMO in cancer--wrestlers wanted. Cancer Biol Ther (2002) 1.01
Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med (2010) 0.99
Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer. Cancer Res (2007) 0.98
Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation. Cell Cycle (2006) 0.98
BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma. Pigment Cell Melanoma Res (2009) 0.98
Mdm2: A regulator of cell growth and death. Adv Cancer Res (2003) 0.97
Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy. Cancer Res (2012) 0.97
Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension (2006) 0.97
c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J Biol Chem (2003) 0.96
c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. J Biol Chem (2009) 0.94
Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc. Oncogene (2002) 0.93
Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137. Proc Natl Acad Sci U S A (2004) 0.93
Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis (2006) 0.93
Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor. Mol Cell Biol (2007) 0.92
Mono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1. J Biol Chem (2011) 0.92
JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol (2005) 0.92
In vitro cleavage of Nedd8 from cullin 1 by COP9 signalosome and deneddylase 1. Methods Enzymol (2005) 0.92
The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination. J Biol Chem (2010) 0.91
The cullin7 E3 ubiquitin ligase: a novel player in growth control. Cell Cycle (2008) 0.90
GST function in drug and stress response. Drug Resist Updat (1999) 0.90
Fbx8 makes Arf6 refractory to function via ubiquitination. Mol Biol Cell (2007) 0.90
Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. Genetics (2010) 0.89
Autophosphorylation properties of inactive and active JNK2. Cell Cycle (2007) 0.89
IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model. Cancer Res (2008) 0.88
Requirements for PKC-augmented JNK activation by MKK4/7. Int J Biochem Cell Biol (2007) 0.88
JAMP optimizes ERAD to protect cells from unfolded proteins. Mol Biol Cell (2008) 0.88
Laparoscopic accessory splenectomy: the value of perioperative localization studies. Surg Endosc (2009) 0.87
Siah: new players in the cellular response to hypoxia. Cell Cycle (2004) 0.87