Published in Mol Cell on May 01, 2001
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70
Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro. J Virol (2002) 4.06
The many faces and functions of β-catenin. EMBO J (2012) 3.85
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The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
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Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors. Genome Res (2010) 2.41
Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem J (2003) 2.26
Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus. Plant Cell (2002) 2.21
Arabidopsis SGT1b is required for defense signaling conferred by several downy mildew resistance genes. Plant Cell (2002) 2.18
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The links between axin and carcinogenesis. J Clin Pathol (2005) 2.07
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res (2010) 2.05
T-cell factors: turn-ons and turn-offs. EMBO J (2002) 2.00
Functional interaction between peroxisome proliferator-activated receptor gamma and beta-catenin. Mol Cell Biol (2006) 1.95
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IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell (2003) 1.86
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Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1. Proc Natl Acad Sci U S A (2002) 1.83
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
Nitric oxide-GAPDH-Siah: a novel cell death cascade. Cell Mol Neurobiol (2006) 1.75
Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75
The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73
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Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell (2003) 1.62
iTRAQ based quantitative proteomics approach validated the role of calcyclin binding protein (CacyBP) in promoting colorectal cancer metastasis. Mol Cell Proteomics (2013) 1.61
Down-regulation of beta-catenin by activated p53. Mol Cell Biol (2001) 1.60
Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. Cell Cycle (2011) 1.59
The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J (2002) 1.57
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A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia (2004) 1.54
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Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J (2002) 1.44
A binding motif for Siah ubiquitin ligase. Proc Natl Acad Sci U S A (2003) 1.43
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proc Natl Acad Sci U S A (2008) 1.42
The molecular programme of tumour reversion: the steps beyond malignant transformation. Nat Rev Cancer (2009) 1.39
Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A (2003) 1.38
The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. J Biol Chem (2010) 1.38
Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol (2002) 1.34
Identification and characterization of components of a putative petunia S-locus F-box-containing E3 ligase complex involved in S-RNase-based self-incompatibility. Plant Cell (2006) 1.33
Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol Cell Biol (2003) 1.33
Siah-1 binds and regulates the function of Numb. Proc Natl Acad Sci U S A (2001) 1.33
RAR1 and HSP90 form a complex with Rac/Rop GTPase and function in innate-immune responses in rice. Plant Cell (2007) 1.30
The ubiquitin ligase Siah2 and the hypoxia response. Mol Cancer Res (2009) 1.29
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem Res (2007) 1.22
Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth. J Natl Cancer Inst (2008) 1.22
Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol Cell Biol (2002) 1.20
PCAF acetylates {beta}-catenin and improves its stability. Mol Biol Cell (2008) 1.18
The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol (2002) 1.18
Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. J Biol Chem (2009) 1.18
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18
Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling. BMC Genomics (2014) 1.16
The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell (2010) 1.15
Generation and analysis of Siah2 mutant mice. Mol Cell Biol (2003) 1.15
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol (2010) 1.14
TBLR1 regulates the expression of nuclear hormone receptor co-repressors. BMC Cell Biol (2006) 1.14
Ubiquitination and degradation of the inhibitors of NF-kappaB. Cold Spring Harb Perspect Biol (2010) 1.13
Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis. Pigment Cell Melanoma Res (2009) 1.12
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J Biol Chem (2006) 1.11
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol (2009) 1.11
Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Proc Natl Acad Sci U S A (2004) 1.10
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. Oncogene (2004) 1.10
The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle (2010) 1.08
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol (2002) 1.08
Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway. Proc Natl Acad Sci U S A (2005) 1.07
LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Mol Cell Biol (2006) 1.07
Looking beyond the Wnt pathway for the deep nature of β-catenin. EMBO Rep (2013) 1.06
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05
Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry (2008) 1.04
Molecular architecture of the DNA replication origin activation checkpoint. EMBO J (2010) 1.04
The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol Cell (2012) 1.03
Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. J Histochem Cytochem (2008) 1.02
Tumor viruses and cell signaling pathways: deubiquitination versus ubiquitination. Mol Cell Biol (2004) 1.02
Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. EMBO J (2005) 1.02
Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. Biochem J (2007) 1.01
Proteomic consequences of a single gene mutation in a colorectal cancer model. J Proteome Res (2011) 1.01
Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells. Proc Natl Acad Sci U S A (2005) 1.00
Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol (2002) 0.99
CacyBP/SIP expression is involved in the clinical progression of breast cancer. World J Surg (2010) 0.99
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance. J Cancer Res Clin Oncol (2011) 0.96
Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation. Mol Cell Biol (2010) 0.96
Caspase-mediated cleavage of beta-catenin precedes drug-induced apoptosis in resistant cancer cells. J Biol Chem (2009) 0.96
A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway. J Biol Chem (2012) 0.94
p53 governs telomere regulation feedback too, via TRF2. Aging (Albany NY) (2011) 0.93
Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J Gastroenterol (2008) 0.93
c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation. J Biol Chem (2013) 0.92
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 lysine 4 demethylase KDM5C. BMC Med Genomics (2013) 0.92
Regulators and effectors of Siah ubiquitin ligases. Cell Biochem Biophys (2013) 0.91
SIAH-1 interacts with the Kaposi's sarcoma-associated herpesvirus-encoded ORF45 protein and promotes its ubiquitylation and proteasomal degradation. J Virol (2007) 0.91
ARTS and Siah collaborate in a pathway for XIAP degradation. Mol Cell (2010) 0.91
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