Published in Bioorg Med Chem Lett on September 14, 2006
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer. Genes Chromosomes Cancer (2006) 5.39
Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature (2012) 4.13
Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res (2005) 3.98
A cabled acoustic telemetry system for detecting and tracking juvenile salmon: part 2. Three-dimensional tracking and passage outcomes. Sensors (Basel) (2011) 3.66
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Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol (2009) 3.32
RAR and RXR modulation in cancer and metabolic disease. Nat Rev Drug Discov (2007) 3.07
4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med (2004) 3.01
A DNA microarray survey of gene expression in normal human tissues. Genome Biol (2005) 2.90
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A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis. Mod Pathol (2007) 2.47
Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer. Neoplasia (2005) 2.35
Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorg Med Chem Lett (2008) 2.17
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med (2006) 2.16
HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res (2010) 2.11
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. J Clin Oncol (2010) 2.04
Gene copy number variation spanning 60 million years of human and primate evolution. Genome Res (2007) 2.02
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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther (2007) 1.85
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia. Cancer Res (2008) 1.77
Hypercalcemia in acute lymphoblastic leukemia: an overview. J Pediatr Hematol Oncol (2009) 1.76
Ingroup identity as an obstacle to effective multiprofessional and interprofessional teamwork: findings from an ethnographic study of healthcare assistants in dementia care. J Interprof Care (2011) 1.57
Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol (2014) 1.56
An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML. Blood (2008) 1.51
Design and implementation of an underwater sound recording device. Sensors (Basel) (2011) 1.49
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. J Clin Oncol (2013) 1.43
SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings. Pediatr Blood Cancer (2014) 1.41
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther (2011) 1.41
Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genet (2008) 1.39
Rare benign and malignant appendiceal lesions: spectrum of computed tomography findings with pathologic correlation. J Comput Assist Tomogr (2003) 1.38
Threshold for onset of injury in Chinook salmon from exposure to impulsive pile driving sounds. PLoS One (2012) 1.35
Design parameters of a miniaturized piezoelectric underwater acoustic transmitter. Sensors (Basel) (2012) 1.33
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma. Acta Neuropathol (2011) 1.33
Rapid diagnosis of medulloblastoma molecular subgroups. Clin Cancer Res (2011) 1.33
Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma. PLoS One (2009) 1.33
Recovery of barotrauma injuries in Chinook salmon, Oncorhynchus tshawytscha from exposure to pile driving sound. PLoS One (2012) 1.28
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies. Acta Neuropathol (2013) 1.27
A gene expression signature of genetic instability in colon cancer. Cancer Res (2005) 1.23
Effects of exposure to pile-driving sounds on the lake sturgeon, Nile tilapia and hogchoker. Proc Biol Sci (2012) 1.18
Biochemical and molecular characterization of a mutation that confers a decreased raffinosaccharide and phytic acid phenotype on soybean seeds. Plant Physiol (2002) 1.17
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer. Mol Oncol (2008) 1.16
ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet (2008) 1.15
Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res (2011) 1.13
Glucose-induced conformational changes in glucokinase mediate allosteric regulation: transient kinetic analysis. Biochemistry (2006) 1.13
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Res (2010) 1.13
Frequent IDH1 mutations in supratentorial primitive neuroectodermal tumors (sPNET) of adults but not children. Cell Cycle (2009) 1.13
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis (2003) 1.13
4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. Cytokine (2006) 1.13
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathol (2013) 1.12
Short-term clinical outcomes for 100 consecutive cases of laparoscopic pylorus-preserving pancreatoduodenectomy: improvement with surgical experience. Surg Endosc (2012) 1.12
Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood. J Comp Neurol (2007) 1.09
RPE65 surface epitopes, protein interactions, and expression in rod- and cone-dominant species. Mol Vis (2005) 1.09
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res (2003) 1.08
Validating a simple scoring system to predict malignancy and invasiveness of intraductal papillary mucinous neoplasms of the pancreas. World J Surg (2010) 1.08
Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy. Cancer Res (2007) 1.08
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. Neuro Oncol (2008) 1.07
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem (2014) 1.07
Results of cystocele repair: a comparison of traditional anterior colporrhaphy, polypropylene mesh and porcine dermis. J Urol (2007) 1.05
4-1BB functions as a survival factor in dendritic cells. J Immunol (2009) 1.05
Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol (2003) 1.05
Adult intestinal intussusception: can abdominal MDCT distinguish an intussusception caused by a lead point? Abdom Imaging (2008) 1.04
Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. PLoS One (2011) 1.03
Aquatic acoustic metrics interface utility for underwater sound monitoring and analysis. Sensors (Basel) (2012) 1.03
Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology (2005) 1.01
Epigenetic inactivation of MCJ (DNAJD1) in malignant paediatric brain tumours. Int J Cancer (2006) 1.00
Recovery of barotrauma injuries resulting from exposure to pile driving sound in two sizes of hybrid striped bass. PLoS One (2013) 0.98
TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas. J Clin Oncol (2011) 0.96
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates. Bioorg Med Chem Lett (2005) 0.96
Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade. Carcinogenesis (2007) 0.96
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol (2010) 0.96
Liverome: a curated database of liver cancer-related gene signatures with self-contained context information. BMC Genomics (2011) 0.95
Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. J Exp Clin Cancer Res (2012) 0.95
Favorable long-term outcome after drug-eluting stent implantation in nonbifurcation lesions that involve unprotected left main coronary artery: a multicenter registry. Circulation (2007) 0.95
Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. Endocrinology (2002) 0.93
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg Med Chem Lett (2010) 0.92
A 200-year perspective on alternative stable state theory and lake management from a biomanipulated shallow lake. Ecol Appl (2012) 0.90
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes. Biochemistry (2010) 0.90
Lactate kinetics at the lactate threshold in trained and untrained men. J Appl Physiol (1985) (2013) 0.90
Differential effects of allergen challenge on large and small airway reactivity in mice. PLoS One (2013) 0.90
4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors. Bioorg Med Chem Lett (2010) 0.90
HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis. Cancer Lett (2012) 0.89
Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells. Haematologica (2006) 0.89
Histologically defined central nervous system primitive neuro-ectodermal tumours (CNS-PNETs) display heterogeneous DNA methylation profiles and show relationships to other paediatric brain tumour types. Acta Neuropathol (2013) 0.89
Gluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold. J Appl Physiol (1985) (2012) 0.89
Vitamin D status in paediatric patients with cancer. Pediatr Blood Cancer (2011) 0.89
Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations. J Biol Chem (2006) 0.89
Effects of exposure to pile driving sounds on fish inner ear tissues. Comp Biochem Physiol A Mol Integr Physiol (2013) 0.88
4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation. J Leukoc Biol (2007) 0.88
Synthesis and SAR of 4-substituted-2-aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors. Bioorg Med Chem Lett (2009) 0.88
Determination of cystic duct patency using hepatobiliary MRI with gadoxetate disodium: is T1 precontrast imaging necessary? J Magn Reson Imaging (2011) 0.87