Published in Curr Biol on September 14, 2006
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell (2009) 6.92
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
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STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity. N Engl J Med (2009) 2.72
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STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Proc Natl Acad Sci U S A (2009) 2.67
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Crystal structure of the calcium release-activated calcium channel Orai. Science (2012) 2.58
Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol (2008) 2.50
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Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32
STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30
STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol (2008) 2.29
Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell (2010) 2.29
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem Biophys Res Commun (2009) 2.28
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc Natl Acad Sci U S A (2008) 2.22
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A (2007) 2.17
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol (2008) 2.11
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia. J Allergy Clin Immunol (2009) 2.09
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STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation. EMBO J (2011) 1.80
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STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77
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Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell (2008) 1.72
CRAC channelopathies. Pflugers Arch (2010) 1.71
Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE). J Biol Chem (2008) 1.71
Some assembly required: constructing the elementary units of store-operated Ca2+ entry. Cell Calcium (2007) 1.70
Activation and regulation of store-operated calcium entry. J Cell Mol Med (2010) 1.70
A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J Biol Chem (2010) 1.67
Calcium signalling and cell-fate choice in B cells. Nat Rev Immunol (2007) 1.64
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
New molecular players in capacitative Ca2+ entry. J Cell Sci (2007) 1.61
Structural determinants of ion permeation in CRAC channels. Proc Natl Acad Sci U S A (2009) 1.61
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Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1). Proc Natl Acad Sci U S A (2012) 1.59
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Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1. J Cell Sci (2007) 1.55
Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. J Physiol (2007) 1.54
Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. J Physiol (2007) 1.53
Pore architecture of the ORAI1 store-operated calcium channel. Proc Natl Acad Sci U S A (2010) 1.52
Orai3 constitutes a native store-operated calcium entry that regulates non small cell lung adenocarcinoma cell proliferation. PLoS One (2013) 1.52
New insights on mast cell activation via the high affinity receptor for IgE. Adv Immunol (2008) 1.51
ORAI and store-operated calcium influx in human airway smooth muscle cells. Am J Respir Cell Mol Biol (2008) 1.50
Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. Circ Res (2011) 1.50
Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits. Cell Res (2010) 1.48
Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1. J Physiol (2008) 1.48
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Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. J Physiol (2009) 1.46
Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. PLoS Biol (2011) 1.45
Immunodeficiency due to mutations in ORAI1 and STIM1. Clin Immunol (2010) 1.39
An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem J (2009) 1.38
Cytoplasmic calcium oscillations and store-operated calcium influx. J Physiol (2008) 1.37
Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34
The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol (2009) 1.34
Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency. J Immunol (2011) 1.32
Location and function of STIM1 in the activation of Ca2+ entry signals. J Biol Chem (2008) 1.30
Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line. J Immunol (2008) 1.30
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins. Cell Calcium (2009) 1.28
New developments in the signaling mechanisms of the store-operated calcium entry pathway. Pflugers Arch (2008) 1.28
Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. Proc Natl Acad Sci U S A (2011) 1.27
Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. Clin Exp Pharmacol Physiol (2008) 1.25
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun (2013) 1.25
The molecular physiology of CRAC channels. Immunol Rev (2009) 1.24
A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol (2010) 1.24
Compromised store-operated Ca2+ entry in aged skeletal muscle. Aging Cell (2008) 1.23
Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem (2009) 1.21
The long and arduous road to CRAC. Cell Calcium (2007) 1.21
STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
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Orai channel pore properties and gating by STIM: implications from the Orai crystal structure. Sci Signal (2013) 1.12
Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria. J Biol Chem (2011) 1.11
Intracellular Ca2+ signaling and store-operated Ca2+ entry are required in Drosophila neurons for flight. Proc Natl Acad Sci U S A (2009) 1.11
Molecular biophysics of Orai store-operated Ca2+ channels. Biophys J (2015) 1.09
Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel. J Biol Chem (2010) 1.09
Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms. Mol Cell (2015) 1.09
Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol (2006) 6.31
Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem (2006) 4.98
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
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STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A (2006) 3.32
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell (2002) 3.13
CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. Curr Biol (2007) 3.12
Comparison and evaluation of methods for liver segmentation from CT datasets. IEEE Trans Med Imaging (2009) 3.03
New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol (2007) 2.99
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TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol (2003) 2.86
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol (2008) 2.71
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci (2010) 2.57
The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science (2010) 2.46
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Curr Biol (2006) 2.38
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A (2006) 2.30
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem (2003) 2.26
Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J Physiol (2002) 2.16
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol Cell (2005) 2.15
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol (2008) 2.11
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity (2003) 2.02
TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Proc Natl Acad Sci U S A (2003) 2.01
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Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J (2006) 1.81
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol (2010) 1.77
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. J Biol Chem (2007) 1.77
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77
TRPM7 channel is regulated by magnesium nucleotides via its kinase domain. J Gen Physiol (2006) 1.76
TRPM5 regulates glucose-stimulated insulin secretion. Pflugers Arch (2010) 1.74
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Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell (2008) 1.72
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A (2009) 1.70
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Postnuclear supernatant: an in vitro model for assessing cadmium-induced neurotoxicity. Biol Trace Elem Res (2011) 1.43
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40