Published in Proc Natl Acad Sci U S A on April 17, 2009
STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol (2012) 2.90
The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science (2010) 2.46
STIM proteins and the endoplasmic reticulum-plasma membrane junctions. Annu Rev Biochem (2011) 1.91
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation. EMBO J (2011) 1.80
STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals. J Biol Chem (2009) 1.59
Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics. J Cell Biol (2014) 1.56
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse. Blood (2010) 1.56
Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expression. Nat Chem Biol (2011) 1.50
Store-Operated Calcium Channels. Physiol Rev (2015) 1.46
Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochem J (2009) 1.38
The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels. J Biol Chem (2009) 1.37
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins. Cell Calcium (2009) 1.28
The molecular physiology of CRAC channels. Immunol Rev (2009) 1.24
STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release. J Cell Biol (2011) 1.20
Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. PLoS One (2011) 1.17
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nat Commun (2014) 1.16
Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borate. J Biol Chem (2010) 1.12
Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx. Nat Cell Biol (2015) 1.09
Orai3--the 'exceptional' Orai? J Physiol (2011) 1.07
Calcium signaling by STIM and Orai: intimate coupling details revealed. Sci Signal (2010) 1.04
Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complex. J Biol Chem (2011) 1.02
Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. J Biol Chem (2012) 1.02
Human muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2. J Biol Chem (2010) 0.99
Calcium signals: STIM dynamics mediate spatially unique oscillations. Curr Biol (2009) 0.99
The role of calcium release activated calcium channels in osteoclast differentiation. J Cell Physiol (2011) 0.98
Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J (2012) 0.97
Evidence for an interaction between Golli and STIM1 in store-operated calcium entry. Biochem J (2010) 0.96
Mitochondria in lung diseases. Expert Rev Respir Med (2013) 0.93
Pore waters regulate ion permeation in a calcium release-activated calcium channel. Proc Natl Acad Sci U S A (2013) 0.92
Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. Nat Commun (2015) 0.91
A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel. Channels (Austin) (2012) 0.90
Transcriptional mechanisms regulating Ca(2+) homeostasis. Cell Calcium (2010) 0.90
A TRPC1 protein-dependent pathway regulates osteoclast formation and function. J Biol Chem (2013) 0.88
Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs. Cell Calcium (2014) 0.87
Molecular pharmacology of store-operated CRAC channels. Channels (Austin) (2013) 0.87
2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm. Biochem J (2012) 0.86
Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2. Am J Physiol Cell Physiol (2012) 0.86
A cytosolic STIM2 preprotein created by signal peptide inefficiency activates ORAI1 in a store-independent manner. J Biol Chem (2011) 0.85
CRAC channel gating and its modulation by STIM1 and 2-aminoethoxydiphenyl borate. J Physiol (2016) 0.83
17β-Estradiol inhibits phosphorylation of stromal interaction molecule 1 (STIM1) protein: implication for store-operated calcium entry and chronic lung diseases. J Biol Chem (2013) 0.83
Preservation of serotonin-mediated contractility in adult sheep pulmonary arteries following long-term high-altitude hypoxia. High Alt Med Biol (2011) 0.83
WT1/EGR1-mediated control of STIM1 expression and function in cancer cells. Front Biosci (Landmark Ed) (2011) 0.82
STIM1 dimers undergo unimolecular coupling to activate Orai1 channels. Nat Commun (2015) 0.81
Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer. Cancer Res (2015) 0.80
Reversal of murine epidermal atrophy by topical modulation of calcium signaling. J Invest Dermatol (2013) 0.79
STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions. Sci Signal (2015) 0.78
Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production. Sci Signal (2015) 0.78
Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel. Biophys J (2016) 0.77
Regulation and roles of Ca2+ stores in human sperm. Reproduction (2015) 0.77
The Orai1 Store-operated Calcium Channel Functions as a Hexamer. J Biol Chem (2016) 0.77
Molecular determinants for STIM1 activation during store-operated Ca2+ entry. Curr Mol Med (2017) 0.77
Molecular mechanisms underlying inhibition of STIM1-Orai1-mediated Ca(2+) entry induced by 2-aminoethoxydiphenyl borate. Pflugers Arch (2016) 0.76
Application of fluorescence resonance energy transfer in protein studies. J Mol Struct (2014) 0.76
2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1. Sci Rep (2016) 0.76
The TRPM7 channel kinase regulates store-operated calcium entry. J Physiol (2017) 0.75
Sequential Steps of CRAC Channel Activation. Cell Rep (2017) 0.75
ER-Plasma Membrane Junctions: Why and How Do We Study Them? Biochim Biophys Acta (2017) 0.75
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol (2005) 13.11
Store-operated calcium channels. Physiol Rev (2005) 11.95
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science (2006) 9.61
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J Cell Biol (2006) 6.88
Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol (2006) 6.31
STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol (2006) 5.58
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. Science (2000) 5.04
Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem (2006) 4.98
The molecular choreography of a store-operated calcium channel. Nature (2007) 4.80
Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors. J Physiol (2001) 4.78
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J Biol Chem (2008) 4.20
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell (2007) 3.75
Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature (2008) 3.67
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature (2008) 3.46
Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell (2008) 3.43
The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol (2002) 3.40
STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A (2006) 3.32
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Curr Biol (2006) 2.38
Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32
STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy. J Physiol (2008) 2.29
2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol (2008) 2.11
Dissecting ICRAC, a store-operated calcium current. Trends Biochem Sci (2007) 1.82
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77
Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell (2008) 1.72
Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem (2005) 1.69
Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J Biol Chem (2001) 1.68
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size. J Biol Chem (2008) 1.66
Role of STIM and Orai proteins in the store-operated calcium signaling pathway. Cell Calcium (2007) 1.62
Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics. J Biol Chem (2008) 1.46
Location and function of STIM1 in the activation of Ca2+ entry signals. J Biol Chem (2008) 1.30
CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr Biol (2006) 6.02
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol (2003) 5.28
Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem (2006) 4.98
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2006) 3.47
The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol (2002) 3.40
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell (2002) 3.36
STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. Proc Natl Acad Sci U S A (2006) 3.32
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol (2012) 2.90
TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity (2011) 2.60
Zinc is a novel intracellular second messenger. J Cell Biol (2007) 2.46
The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Science (2010) 2.46
Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol (2007) 2.38
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Curr Biol (2006) 2.38
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell (2012) 2.35
B cell signaling and fate decision. Annu Rev Immunol (2010) 2.33
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci U S A (2006) 2.30
TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J (2006) 2.28
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem (2003) 2.26
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity (2008) 2.16
Neural anomaly and reorganization in speakers who stutter: a short-term intervention study. Neurology (2012) 2.14
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell (2008) 2.13
Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A (2009) 2.08
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol (2007) 2.05
Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet (2004) 1.98
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nat Neurosci (2007) 1.95
Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature (2005) 1.94
Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell (2002) 1.92
Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol (2004) 1.91
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A (2006) 1.87
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J Cell Biol (2010) 1.77
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J (2007) 1.77
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nat Neurosci (2009) 1.75
Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. J Cell Biol (2005) 1.73
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. Sci Signal (2009) 1.71
Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem (2005) 1.69
Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J Biol Chem (2001) 1.68
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med (2008) 1.63
Role of STIM and Orai proteins in the store-operated calcium signaling pathway. Cell Calcium (2007) 1.62
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med (2012) 1.61
STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals. J Biol Chem (2009) 1.59
FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation. Blood (2009) 1.59
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels (Austin) (2008) 1.59
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med (2005) 1.57
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci (2004) 1.56
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A (2006) 1.55
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. J Mol Biol (2006) 1.54
Enhanced NK-cell development and function in BCAP-deficient mice. Blood (2008) 1.53
Long-term low-dose spironolactone therapy is safe in oligoanuric hemodialysis patients. Cardiology (2009) 1.49
A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem (2005) 1.49
Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci U S A (2010) 1.48
The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity (2011) 1.48
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood (2007) 1.48
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice. J Cardiovasc Electrophysiol (2011) 1.47
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem (2007) 1.44
Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal (2010) 1.44
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med (2003) 1.44
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest (2013) 1.40
Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem (2009) 1.38
The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels. J Biol Chem (2009) 1.37