Published in Chem Biol on September 01, 2006
Epoxide-opening cascades in the synthesis of polycyclic polyether natural products. Angew Chem Int Ed Engl (2009) 1.13
Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Appl Environ Microbiol (2011) 0.94
Type II thioesterase ScoT, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference for propionate. Appl Environ Microbiol (2008) 0.91
Three thioesterases are involved in the biosynthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes Tü494. Antimicrob Agents Chemother (2008) 0.84
Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. Appl Environ Microbiol (2008) 0.83
Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol (2008) 0.83
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nat Chem Biol (2016) 0.80
Roles of type II thioesterases and their application for secondary metabolite yield improvement. Appl Microbiol Biotechnol (2014) 0.79
Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. J Am Chem Soc (2017) 0.78
Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to a Responsive Regulator ChlF1. J Biol Chem (2016) 0.76
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity (2004) 3.67
Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nat Genet (2006) 2.86
Structure and mechanism of the 6-deoxyerythronolide B synthase. Annu Rev Biochem (2007) 2.65
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2006) 2.63
Phosphorothioation of DNA in bacteria by dnd genes. Nat Chem Biol (2007) 2.57
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A (2010) 2.29
Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell (2006) 2.26
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chem Biol (2007) 2.02
Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int J Radiat Oncol Biol Phys (2008) 1.86
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity (2005) 1.85
TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea. Nucleic Acids Res (2010) 1.83
A novel DNA modification by sulphur. Mol Microbiol (2005) 1.79
Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum. J Bacteriol (2012) 1.77
Geometric and potential driving formation and evolution of biomolecular surfaces. J Math Biol (2008) 1.76
mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Res (2010) 1.73
DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A (2011) 1.69
Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Sci (2007) 1.68
A gene cluster for biosynthesis of the sesquiterpenoid antibiotic pentalenolactone in Streptomyces avermitilis. Biochemistry (2006) 1.67
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry (2002) 1.66
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2006) 1.63
ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria. Nucleic Acids Res (2011) 1.62
GFR estimating equations in a multiethnic Asian population. Am J Kidney Dis (2011) 1.57
MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res (2007) 1.56
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2007) 1.56
Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis. J Am Chem Soc (2004) 1.55
A novel DNA modification by sulfur: DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans. Biochemistry (2007) 1.54
'Streptomyces nanchangensis', a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters. Microbiology (2002) 1.54
Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. Nat Chem Biol (2007) 1.53
Interleukin-7 enhances the Th1 response to promote the development of Sjögren's syndrome-like autoimmune exocrinopathy in mice. Arthritis Rheum (2013) 1.53
Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol (2007) 1.53
Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis. J Am Chem Soc (2002) 1.50
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin. J Am Chem Soc (2006) 1.49
X-ray crystal structure of aristolochene synthase from Aspergillus terreus and evolution of templates for the cyclization of farnesyl diphosphate. Biochemistry (2007) 1.49
Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia. J Clin Invest (2007) 1.49
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem (2008) 1.48
Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry (2004) 1.47
Structure-based dissociation of a type I polyketide synthase module. Chem Biol (2007) 1.46
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry (2002) 1.45
Serum gamma-glutamyltransferase level and peripheral arterial disease. Atherosclerosis (2007) 1.45
{N,N-Dimethyl-N'-[phen-yl(2-pyrid-yl)methyl-ene]ethane-1,2-diamine-κN,N',N''}dithio-cyanato-κN,κS-copper(II). Acta Crystallogr Sect E Struct Rep Online (2009) 1.44
Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J Am Chem Soc (2006) 1.44
Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities. Hear Res (2012) 1.43
Contribution of epidermal stem cells to hypertrophic scars pathogenesis. Med Hypotheses (2009) 1.42
Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59-71. J Immunol (2016) 1.41
Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth Biol (2013) 1.40
The biochemical basis for stereochemical control in polyketide biosynthesis. J Am Chem Soc (2009) 1.39
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. Appl Environ Microbiol (2008) 1.38
A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella. Nucleic Acids Res (2010) 1.36
Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects. Physiol Genomics (2005) 1.35
A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin. Chem Biol (2003) 1.33
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. J Am Chem Soc (2005) 1.33
Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chem Biol (2006) 1.33
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chem Biol (2008) 1.32
X-ray crystal structures of D100E trichodiene synthase and its pyrophosphate complex reveal the basis for terpene product diversity. Biochemistry (2002) 1.31
dndDB: a database focused on phosphorothioation of the DNA backbone. PLoS One (2009) 1.31
Gene cluster responsible for validamycin biosynthesis in Streptomyces hygroscopicus subsp. jinggangensis 5008. Appl Environ Microbiol (2005) 1.31
Revisiting the modularity of modular polyketide synthases. Curr Opin Chem Biol (2009) 1.30
Losartan decreases cardiac muscle fibrosis and improves cardiac function in dystrophin-deficient mdx mice. J Cardiovasc Pharmacol Ther (2011) 1.28
Stem cell-delivery therapeutics for periodontal tissue regeneration. Biomaterials (2012) 1.27
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2010) 1.27
Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chem Biol (2003) 1.27
Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol (2007) 1.27
Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. PLoS Genet (2010) 1.27
Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry (2010) 1.27
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J Am Chem Soc (2003) 1.24
Functional analysis of spfD gene involved in DNA phosphorothioation in Pseudomonas fluorescens Pf0-1. FEBS Lett (2009) 1.24
DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites. Nucleic Acids Res (2007) 1.23
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects. EMBO Mol Med (2013) 1.22
Microporous supramolecular coordination compounds as chemosensory photonic lattices. Angew Chem Int Ed Engl (2002) 1.22
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. J Am Chem Soc (2008) 1.22
Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2). J Am Chem Soc (2004) 1.21
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants. Biochemistry (2005) 1.20