Published in Dev Cell on December 01, 2006
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev (2011) 5.51
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol (2012) 5.12
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature (2010) 3.18
KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity (2009) 2.90
Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12
Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Blood (2009) 2.01
Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res (2012) 1.84
Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci (2012) 1.76
Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity (2010) 1.69
The effects of hemodynamic force on embryonic development. Microcirculation (2010) 1.66
Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart. PLoS Biol (2009) 1.59
The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development (2007) 1.49
Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochem Biophys Res Commun (2009) 1.46
Lymphatic function is required prenatally for lung inflation at birth. J Exp Med (2014) 1.44
Interaction between alk1 and blood flow in the development of arteriovenous malformations. Development (2011) 1.42
Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol (2012) 1.41
Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev (2011) 1.36
Thymic emigration: when and how T cells leave home. J Immunol (2008) 1.31
Genetic framework for GATA factor function in vascular biology. Proc Natl Acad Sci U S A (2011) 1.29
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature (2016) 1.27
HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet (2008) 1.25
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis. Cell (2013) 1.21
Kruppel-like factor 2 cooperates with the ETS family protein ERG to activate Flk1 expression during vascular development. Development (2009) 1.20
ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2. J Exp Med (2015) 1.16
The interplay between cell signalling and mechanics in developmental processes. Nat Rev Genet (2013) 1.13
EKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesis. Blood (2007) 1.11
Kruppel-like factor 2 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol (2010) 1.09
Flow control in our vessels: vascular valves make sure there is no way back. Cell Mol Life Sci (2012) 1.09
B cell homeostasis and plasma cell homing controlled by Krüppel-like factor 2. Proc Natl Acad Sci U S A (2010) 1.08
"Go with the flow": how Krüppel-like factor 2 regulates the vasoprotective effects of shear stress. Antioxid Redox Signal (2011) 1.07
Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell (2012) 1.04
Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling. J Biol Chem (2008) 1.03
Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells. J Immunol (2010) 1.02
Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem (2011) 0.98
Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nat Commun (2013) 0.97
The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell (2015) 0.97
Development of the endothelium: an emphasis on heterogeneity. Semin Thromb Hemost (2010) 0.94
Lymph flow regulates collecting lymphatic vessel maturation in vivo. J Clin Invest (2015) 0.93
Zebrafish genetic models for arrhythmia. Prog Biophys Mol Biol (2009) 0.93
Cardiac outflow tract anomalies. Wiley Interdiscip Rev Dev Biol (2013) 0.92
An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet (2015) 0.92
Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects? Am J Physiol Heart Circ Physiol (2013) 0.91
The development of the heart and microcirculation: role of shear stress. Med Biol Eng Comput (2008) 0.90
Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery. Expert Opin Drug Discov (2010) 0.89
The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. J Biol Chem (2013) 0.88
Krüppel-like factor 2 is required for normal mouse cardiac development. PLoS One (2013) 0.88
Capturing structure and function in an embryonic heart with biophotonic tools. Front Physiol (2014) 0.87
Embryonic expression of the chicken Krüppel-like (KLF) transcription factor gene family. Dev Dyn (2010) 0.87
ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet (2013) 0.87
Life is a pattern: vascular assembly within the embryo. Front Biosci (Elite Ed) (2012) 0.86
Intracardiac flow dynamics regulate atrioventricular valve morphogenesis. Cardiovasc Res (2014) 0.86
The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 0.85
Reduced Krüppel-like factor 2 expression may aggravate the endothelial injury of diabetic nephropathy. Kidney Int (2014) 0.85
Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells. Blood Cells Mol Dis (2011) 0.85
KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc Natl Acad Sci U S A (2014) 0.85
Secreted miRNAs suppress atherogenesis. Nat Cell Biol (2012) 0.85
Kruppel-like factors and vascular inflammation: implications for atherosclerosis. Curr Atheroscler Rep (2012) 0.84
The Krüppel-like factor 2 and Krüppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol (2013) 0.84
Optical coherence tomography captures rapid hemodynamic responses to acute hypoxia in the cardiovascular system of early embryos. Dev Dyn (2012) 0.83
Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve. J Mol Med (Berl) (2012) 0.83
Blood flow mechanics in cardiovascular development. Cell Mol Life Sci (2015) 0.83
Shear stress modulates endothelial KLF2 through activation of P2X4. Purinergic Signal (2015) 0.81
KLF2--a negative regulator of pre-B cell clonal expansion and B cell activation. PLoS One (2014) 0.81
Connecting the coronaries: how the coronary plexus develops and is functionalized. Dev Biol (2014) 0.81
klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes. PLoS One (2015) 0.80
Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy. Am J Pathol (2016) 0.78
Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. Haematologica (2014) 0.78
Characterization of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenatal mouse. PLoS One (2014) 0.78
Signaling in cell differentiation and morphogenesis. Cold Spring Harb Perspect Biol (2012) 0.78
Echocardiographic assessment of embryonic and fetal mouse heart development: a focus on haemodynamics and morphology. ScientificWorldJournal (2014) 0.76
The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo. PLoS One (2014) 0.76
Peripheral tolerance can be modified by altering KLF2-regulated Treg migration. Proc Natl Acad Sci U S A (2016) 0.76
Interplay between cardiac function and heart development. Biochim Biophys Acta (2016) 0.76
Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses. J Immunol (2016) 0.75
Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A. Proc Natl Acad Sci U S A (2017) 0.75
RNA sequencing analysis reveals protective role of kruppel-like factor 3 in colorectal cancer. Oncotarget (2017) 0.75
Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest (2017) 0.75
The critical role of Krüppel-like factors in kidney disease. Am J Physiol Renal Physiol (2016) 0.75
Krüppel-like factors in mammalian stem cells and development. Development (2017) 0.75
Flow pattern-dependent endothelial cell responses through transcriptional regulation. Cell Cycle (2017) 0.75
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol (2010) 13.03
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03
Stepwise reprogramming of B cells into macrophages. Cell (2004) 7.68
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res (2004) 7.56
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A (2003) 5.83
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41
Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell (2002) 4.37
Dynamic visualization of thrombopoiesis within bone marrow. Science (2007) 4.35
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet (2009) 4.28
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet (2004) 3.88
Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity (2004) 3.67
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med (2011) 3.60
Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential. Immunity (2003) 3.59
A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J (2006) 3.43
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol (2008) 3.05
Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development (2004) 2.88
Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nat Genet (2006) 2.86
Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med (2010) 2.82
Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest (2003) 2.76
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell (2009) 2.72
Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nat Chem Biol (2005) 2.64
Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity (2006) 2.58
TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell (2009) 2.58
Heterogeneity of embryonic and adult stem cells. Cell Stem Cell (2008) 2.57
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol (2004) 2.57
Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell (2007) 2.57
Familial aggregation in lone atrial fibrillation. Hum Genet (2005) 2.55
A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update. Eur J Cancer (2013) 2.51
Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation (2003) 2.42
Determinants of lymphoid-myeloid lineage diversification. Annu Rev Immunol (2006) 2.37
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35
Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol (2006) 2.29
Locus for atrial fibrillation maps to chromosome 6q14-16. Circulation (2003) 2.28
Cell population tracking and lineage construction with spatiotemporal context. Med Image Anal (2008) 2.26
Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J (2007) 2.20
The size of the proton. Nature (2010) 2.19
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
A robust and highly efficient immune cell reprogramming system. Cell Stem Cell (2009) 2.06
Correcting motion artifacts in retinal spectral domain optical coherence tomography via image registration. Med Image Comput Comput Assist Interv (2009) 2.06
Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J (2009) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation (2006) 2.04
Geisinger's Retail Innovation Journey. Front Health Serv Manage (2015) 2.03
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (2006) 2.00
Improved tandem affinity purification tag and methods for isolation of protein heterocomplexes from plants. Plant J (2004) 1.99
High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice. Genesis (2005) 1.99
Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J Biol Chem (2004) 1.98
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell (2007) 1.93
Pattern recognition: combining informatics and genetics to re-evaluate conduction disease. Heart (2012) 1.91
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell Stem Cell (2013) 1.91
Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol (2008) 1.88
Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet (2013) 1.87
Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy. Heart Rhythm (2011) 1.85
Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity (2005) 1.85
Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A (2011) 1.85
Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease. Ann Intern Med (2005) 1.85
In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev (2006) 1.80
Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Nat Genet (2005) 1.80
The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex. PLoS Genet (2008) 1.80
In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. Am J Physiol Heart Circ Physiol (2006) 1.77
Rapid high resolution three dimensional reconstruction of embryos with episcopic fluorescence image capture. Birth Defects Res C Embryo Today (2004) 1.74