Published in Hum Mol Genet on September 20, 2006
Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission. PLoS Biol (2011) 1.84
Preclinical safety of RNAi-mediated HTT suppression in the rhesus macaque as a potential therapy for Huntington's disease. Mol Ther (2011) 1.72
Development of allosteric modulators of GPCRs for treatment of CNS disorders. Neurobiol Dis (2013) 1.20
Centrality of striatal cholinergic transmission in Basal Ganglia function. Front Neuroanat (2011) 1.04
Genetics and neuropathology of Huntington's disease. Int Rev Neurobiol (2011) 0.99
Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice. Proc Natl Acad Sci U S A (2015) 0.93
Abnormal motor cortex excitability in preclinical and very early Huntington's disease. Biol Psychiatry (2009) 0.92
Striatal cholinergic interneuron regulation and circuit effects. Front Synaptic Neurosci (2014) 0.91
Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α. PLoS One (2012) 0.89
Transcriptional activation of REST by Sp1 in Huntington's disease models. PLoS One (2010) 0.87
Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter. Bioorg Med Chem (2015) 0.87
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy? Front Cell Neurosci (2013) 0.86
Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI). J Biol Chem (2011) 0.84
Extrinsic Sources of Cholinergic Innervation of the Striatal Complex: A Whole-Brain Mapping Analysis. Front Neuroanat (2016) 0.83
Enhanced GABAergic Inputs Contribute to Functional Alterations of Cholinergic Interneurons in the R6/2 Mouse Model of Huntington's Disease. eNeuro (2015) 0.83
Specific reactions of different striatal neuron types in morphology induced by quinolinic acid in rats. PLoS One (2014) 0.82
Reduced expression of the vesicular acetylcholine transporter and neurotransmitter content affects synaptic vesicle distribution and shape in mouse neuromuscular junction. PLoS One (2013) 0.81
Expression of choline acetyltransferase in rat spinal motoneurons after antiorthostatic suspension. Dokl Biol Sci (2007) 0.80
Radiation dosimetry of [(18)F]VAT in nonhuman primates. EJNMMI Res (2015) 0.80
Cholinergic interneurons in the Q140 knockin mouse model of Huntington's disease: Reductions in dendritic branching and thalamostriatal input. J Comp Neurol (2016) 0.77
Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates. Nucl Med Biol (2015) 0.77
1-Methyl-4-propan-2-ylbenzene from Thymus vulgaris Attenuates Cholinergic Dysfunction. Mol Neurobiol (2016) 0.76
Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease. J Huntingtons Dis (2016) 0.75
Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase. Front Mol Neurosci (2016) 0.75
Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine Modulation. J Huntingtons Dis (2016) 0.75
Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington's Disease. Front Syst Neurosci (2016) 0.75
Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy. Stem Cells Int (2016) 0.75
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum Mol Genet (2016) 0.75
Effect of walnut protein hydrolysate on scopolamine-induced learning and memory deficits in mice. J Food Sci Technol (2017) 0.75
Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's Disease. Front Mol Neurosci (2017) 0.75
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med (2008) 6.90
Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science (2007) 5.23
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol (2012) 5.18
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron (2003) 4.49
Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet (2006) 3.91
Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem (2008) 3.86
Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol (2006) 3.72
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest (2011) 3.53
Caspase signalling controls microglia activation and neurotoxicity. Nature (2011) 3.44
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron (2002) 3.15
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci (2004) 3.09
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurol (2011) 2.99
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci (2002) 2.93
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med (2008) 2.78
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Genet (2007) 2.54
Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci (2008) 2.51
Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration. Nat Genet (2012) 2.45
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proc Natl Acad Sci U S A (2003) 2.36
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A (2013) 2.21
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (2006) 2.07
A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3. J Neuropathol Exp Neurol (2007) 1.95
The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol (2006) 1.91
Beyond the brain: widespread pathology in Huntington's disease. Lancet Neurol (2009) 1.83
The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest. Resuscitation (2012) 1.82
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. PLoS Genet (2010) 1.81
Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci (2002) 1.74
Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci (2009) 1.71
Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain. Nat Methods (2011) 1.70
A role for human brain pericytes in neuroinflammation. J Neuroinflammation (2014) 1.64
Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol (2003) 1.64
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem (2002) 1.64
DNA instability in postmitotic neurons. Proc Natl Acad Sci U S A (2008) 1.61
CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells. Cancer Res (2007) 1.58
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. PLoS Genet (2011) 1.57
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice. Behav Brain Res (2005) 1.56
Clinicopathological concordance in dementia diagnostics. Am J Geriatr Psychiatry (2009) 1.54
Are synucleinopathies prion-like disorders? Lancet Neurol (2010) 1.54
Small N-terminal mutant huntingtin fragments, but not wild type, are mainly present in monomeric form: Implications for pathogenesis. Exp Neurol (2005) 1.53
Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell (2007) 1.51
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. Brain Res (2007) 1.50
Stem cells: hype or hope? Drug Discov Today (2002) 1.48
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease. Mov Disord (2010) 1.47
Indinavir resistance evolution in one human immunodeficiency virus type 1 infected patient revealed by single-genome amplification. Virol Sin (2010) 1.43
Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment. J Biol Chem (2009) 1.41
Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease. Hum Brain Mapp (2011) 1.39
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proc Natl Acad Sci U S A (2004) 1.39
Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice. Neurobiol Dis (2008) 1.38
Critical issues of clinical human embryonic stem cell therapy for brain repair. Trends Neurosci (2008) 1.37
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? Mov Disord (2013) 1.34
Orexin loss in Huntington's disease. Hum Mol Genet (2004) 1.33
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease. Hum Mol Genet (2002) 1.33
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx (2005) 1.33
Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells. Stem Cells (2012) 1.32
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci (2005) 1.31
Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. Acta Neuropathol (2010) 1.31
Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice. Acta Neuropathol (2013) 1.30
The adult human brain harbors multipotent perivascular mesenchymal stem cells. PLoS One (2012) 1.30
Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. Am J Pathol (2007) 1.28
The effect of neurodegenerative diseases on the subventricular zone. Nat Rev Neurosci (2007) 1.28
Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia. J Neurosci (2006) 1.28
MRI with diffusion tensor imaging post-mortem at 3.0 T in a patient with frontotemporal dementia. Dement Geriatr Cogn Disord (2004) 1.27
KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses. Eur J Neurosci (2005) 1.25
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum Mol Genet (2011) 1.25
Alpha-synuclein transfers from neurons to oligodendrocytes. Glia (2013) 1.25
Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia. Int J Geriatr Psychiatry (2006) 1.25
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis. Hum Mol Genet (2005) 1.24
An ovine transgenic Huntington's disease model. Hum Mol Genet (2010) 1.24
Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BMC Bioinformatics (2006) 1.24
Distinct neuroinflammatory profile in post-mortem human Huntington's disease. Neuroreport (2009) 1.23
Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Proc Natl Acad Sci U S A (2002) 1.22
Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS One (2008) 1.20
The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Biol Psychiatry (2005) 1.20
GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. Brain Res Mol Brain Res (2003) 1.20
Stage-specific modulation of cortical neuronal development by Mmu-miR-134. Cereb Cortex (2011) 1.19
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS One (2009) 1.19
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain. Eur J Neurosci (2004) 1.18
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol (2014) 1.18
Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease. Parkinsonism Relat Disord (2010) 1.18
Longitudinal evaluation of "presymptomatic" carriers of Huntington's disease. J Neuropsychiatry Clin Neurosci (2007) 1.18
The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. J Chem Neuroanat (2008) 1.17
Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment. Dement Geriatr Cogn Disord (2002) 1.16
Huntington's disease: a synaptopathy? Trends Mol Med (2003) 1.16
Basal ganglia volume and clinical correlates in 'preclinical' Huntington's disease. J Neurol (2008) 1.15
Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease. Brain Res (2006) 1.15
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One (2012) 1.15