Published in Immunity on September 28, 2006
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science (2013) 3.33
Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell (2012) 3.10
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nat Immunol (2013) 3.02
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol (2008) 2.50
Signaling by the phosphoinositide 3-kinase family in immune cells. Annu Rev Immunol (2013) 2.09
AID and somatic hypermutation. Adv Immunol (2010) 1.74
Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch. EMBO J (2010) 1.62
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Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. J Exp Med (2014) 1.48
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells. Nature (2017) 1.43
A human immunodeficiency caused by mutations in the PIK3R1 gene. J Clin Invest (2014) 1.42
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol (2011) 1.39
Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K. Trends Immunol (2007) 1.38
Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation. Curr Opin Immunol (2011) 1.28
Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol Cell Biol (2010) 1.24
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity (2009) 1.23
Molecular underpinning of B-cell anergy. Immunol Rev (2010) 1.20
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination. Crit Rev Immunol (2007) 1.19
Akt and mTOR in B Cell Activation and Differentiation. Front Immunol (2012) 1.16
PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol (2010) 1.12
Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation. Cell Rep (2015) 1.03
A replicative self-renewal model for long-lived plasma cells: questioning irreversible cell cycle exit. Front Immunol (2013) 0.99
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol (2013) 0.99
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep (2013) 0.99
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A (2014) 0.98
The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J (2012) 0.97
FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J Exp Med (2012) 0.97
The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions. Front Immunol (2012) 0.95
Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol Med (2007) 0.93
Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution. Int Immunol (2009) 0.93
B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol (2013) 0.92
Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med (2016) 0.90
Role of beta-catenin in B cell development and function. J Immunol (2008) 0.89
Cowden's syndrome with immunodeficiency. J Med Genet (2015) 0.89
Defective B-cell response to T-dependent immunization in lupus-prone mice. Eur J Immunol (2008) 0.88
A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair. J Exp Med (2007) 0.87
14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1. Proc Natl Acad Sci U S A (2011) 0.87
AKT/PKB Signaling: Navigating the Network. Cell (2017) 0.87
The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms. FEBS Lett (2010) 0.86
Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Mol Cell Biol (2012) 0.83
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol (2007) 0.83
Aberrant antibody affinity selection in SHIP-deficient B cells. Eur J Immunol (2012) 0.83
Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol (2015) 0.83
PDK1 regulates B cell differentiation and homeostasis. Proc Natl Acad Sci U S A (2014) 0.82
The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization. J Biol Chem (2015) 0.81
2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation. Toxicol Sci (2010) 0.81
Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun (2015) 0.81
PI3Kδ and primary immunodeficiencies. Nat Rev Immunol (2016) 0.81
Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis. World J Gastroenterol (2014) 0.78
The PI3K pathway in B cell metabolism. Crit Rev Biochem Mol Biol (2016) 0.78
PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL). Curr Top Microbiol Immunol (2016) 0.76
Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res (2013) 0.75
Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling. J Clin Invest (2014) 0.75
The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans. Clin Immunol (2016) 0.75
The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K. Self Nonself (2010) 0.75
Regulation of B cell fate by chronic activity of the IgE B cell receptor. Elife (2016) 0.75
Hematopoietic prostaglandin D synthase: Linking pathogenic effector CD4(+) TH2 cells to proeosinophilic inflammation in patients with gastrointestinal allergic disorders. J Allergy Clin Immunol (2016) 0.75
Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity. Clin Rev Allergy Immunol (2017) 0.75
The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. Front Immunol (2017) 0.75
Metabolic Regulation of the Immune Humoral Response. Immunity (2017) 0.75
Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. Nat Commun (2017) 0.75
mTOR-Bach2 cascade controls cell cycle and class switch recombination during B cell differentiation. Mol Cell Biol (2017) 0.75
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity (2002) 6.27
Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity (2003) 5.95
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood (2010) 4.69
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity (2009) 4.42
Regulation of plasma-cell development. Nat Rev Immunol (2005) 3.98
Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol (2006) 3.48
Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol (2008) 3.38
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J (2004) 3.32
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol (2003) 3.10
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol (2008) 2.50
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity (2006) 2.33
Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol Cell Biol (2002) 2.24
The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development (2005) 2.23
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol (2003) 2.05
Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival. J Exp Med (2008) 2.00
IKK beta is required for peripheral B cell survival and proliferation. J Immunol (2003) 1.92
Protein tyrosine phosphatases in autoimmunity. Annu Rev Immunol (2008) 1.90
Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med (2005) 1.86
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. Proc Natl Acad Sci U S A (2007) 1.85
Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol (2009) 1.77
Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor. Mol Cell Biol (2003) 1.76
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma. Blood (2010) 1.75
Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas. EMBO Mol Med (2009) 1.73
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity (2004) 1.65
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J (2006) 1.63
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood (2005) 1.60
PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP. J Cell Sci (2008) 1.54
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol (2006) 1.52
Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity (2007) 1.50
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia. Blood (2011) 1.45
Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med (2007) 1.41
LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol (2012) 1.37
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A (2010) 1.34
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol (2004) 1.34
Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood (2007) 1.33
The physiologic role of CD19 cytoplasmic tyrosines. Immunity (2002) 1.25
Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils. Eur J Immunol (2008) 1.25
Cyclin D3 is selectively required for proliferative expansion of germinal center B cells. Mol Cell Biol (2010) 1.24
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity (2009) 1.23
B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion. J Exp Med (2006) 1.21
CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B cells requires CD19-dependent survival signals. J Immunol (2003) 1.20
Transcriptional regulatory cascades controlling plasma cell differentiation. Immunol Rev (2003) 1.19
CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition. J Immunol (2003) 1.18
Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases. J Exp Med (2010) 1.10
CD19 function in central and peripheral B-cell development. Immunol Res (2005) 1.10
PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation. J Autoimmun (2011) 1.10
Requirement for Rictor in homeostasis and function of mature B lymphoid cells. Blood (2013) 1.09
ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Blood (2003) 1.09
Plasma cell differentiation and multiple myeloma. Curr Opin Immunol (2004) 1.08
Regulatory events in early and late B-cell differentiation. Mol Immunol (2005) 1.07
Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma. J Allergy Clin Immunol (2006) 1.02
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A (2007) 1.02
HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium. Eur J Immunol (2010) 1.01
Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation. Mol Cell Biol (2009) 1.00
CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol (2009) 1.00
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol (2008) 1.00
Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol (2006) 1.00
Context-specific BAFF-R signaling by the NF-κB and PI3K pathways. Cell Rep (2013) 0.99
A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J Immunol (2005) 0.98
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem (2013) 0.96
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids. J Med Chem (2010) 0.94
In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation. ChemMedChem (2009) 0.94
Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol (2009) 0.93
Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol (2004) 0.90
Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice. Autoimmunity (2013) 0.89
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses. Hum Immunol (2013) 0.87
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.86
Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response. PLoS One (2007) 0.86
Transcription factors controlling the beginning and end of B-cell differentiation. Curr Opin Genet Dev (2003) 0.86
IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle. J Immunol (2012) 0.85
Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice. Genes Cancer (2010) 0.85
Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis. Nat Protoc (2011) 0.84
Multiple roles for Blimp-1 in B and T lymphocytes. Adv Exp Med Biol (2007) 0.84
An interfering form of Blimp-1 increases IgM secreting plasma cells and blocks maturation of peripheral B cells. Eur J Immunol (2002) 0.83
Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies. J Nanosci Nanotechnol (2008) 0.82
SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A (2010) 0.80
Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response. Cell Cycle (2007) 0.80
Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med (2012) 0.80
Introduction of genes into primary murine splenic B cells using retrovirus vectors. Methods Mol Biol (2004) 0.76
Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen. J Immunol (2013) 0.76
Introduction to COI volume on lymphocyte activation 2008. Curr Opin Immunol (2008) 0.75
Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines. J Org Chem (2009) 0.75
Retraction. Genes Dev (2002) 0.75