Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell (2007) 6.16

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J (2004) 4.26

Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol (2007) 3.51

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med (2003) 2.62

MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle (2010) 2.18

MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PLoS One (2007) 1.61

HIF transcription factors, inflammation, and immunity. Immunity (2014) 1.55

HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol (2010) 1.48

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. Mol Cell Biol (2005) 1.47

N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion. PLoS One (2013) 1.46

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis. EMBO J (2010) 1.41

HIF-1 and tumour radiosensitivity. Br J Cancer (2006) 1.41

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J (2006) 1.38

Hypoxia-driven pathways in bone development, regeneration and disease. Nat Rev Rheumatol (2012) 1.36

Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do! Ann Rheum Dis (2005) 1.35

Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res (2005) 1.35

Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc Natl Acad Sci U S A (2005) 1.31

Hypoxia, HIFs and bone development. Bone (2010) 1.29

HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiol Dis (2008) 1.28

Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One (2010) 1.27

HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. Blood (2012) 1.26

HIF activation protects from acute kidney injury. J Am Soc Nephrol (2008) 1.25

Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24

Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol (2004) 1.22

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol Res (2013) 1.19

Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res (2012) 1.17

A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17

MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell (2011) 1.17

Hypoxia-inducible factor-1alpha suppresses squamous carcinogenic progression and epithelial-mesenchymal transition. Cancer Res (2009) 1.15

Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α. Carcinogenesis (2011) 1.13

Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells. Diabetes (2009) 1.12

Bone marrow-derived immune cells regulate vascular disease through a p27(Kip1)-dependent mechanism. J Clin Invest (2004) 1.11

HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood (2012) 1.10

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells. Am J Physiol Cell Physiol (2010) 1.10

Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery. Am J Physiol Cell Physiol (2011) 1.07

Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res (2004) 1.06

Hypoxia-induced signaling in the cardiovascular system. Annu Rev Physiol (2008) 1.04

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation. Neoplasia (2010) 1.03

p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab (2005) 1.01

Hyperbaric oxygen therapy for malignancy: a review. World J Surg (2006) 1.01

HIF-1: an age-dependent regulator of lens cell proliferation. Invest Ophthalmol Vis Sci (2008) 1.00

Hypoxia-induced alternative splicing in endothelial cells. PLoS One (2012) 0.99

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle (2013) 0.98

MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. J Am Soc Nephrol (2015) 0.98

Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1alpha. J Cancer Res Clin Oncol (2009) 0.95

Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. Am J Pathol (2008) 0.95

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival. Cancer Biol Ther (2008) 0.95

Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS One (2011) 0.94

Single-cell analysis demonstrates how nutrient deprivation creates apoptotic and quiescent cell populations in tumor cylindroids. Biotechnol Bioeng (2008) 0.94

Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice. Am J Pathol (2007) 0.94

Oxygen Sensing and Homeostasis. Physiology (Bethesda) (2015) 0.93

Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis. J Biol Chem (2009) 0.92

Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue Eng Part A (2014) 0.92

Conditional hypoxia inducible factor-1α induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol (2011) 0.92

HIF2 alpha reduces growth rate but promotes angiogenesis in a mouse model of neuroblastoma. BMC Cancer (2007) 0.92

Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury. Exp Neurol (2008) 0.91

Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Cell Biol (2003) 0.90

Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res (2011) 0.89

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J (2011) 0.89

Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas. Virchows Arch (2005) 0.88

Sprouty1 inhibits angiogenesis in association with up-regulation of p21 and p27. Mol Cell Biochem (2010) 0.88

Myocardial transfection of hypoxia-inducible factor-1α and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction. Stem Cell Res Ther (2014) 0.87

HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS One (2012) 0.87

PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. PLoS One (2016) 0.87

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc Natl Acad Sci U S A (2014) 0.86

KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. PLoS One (2012) 0.86

Hypoxia-inducible factor-2α-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem (2013) 0.85

Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol (2011) 0.85

Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Nucleic Acids Res (2006) 0.84

Interplay Between Metabolism and Oncogenic Process: Role of microRNAs. Transl Oncogenomics (2015) 0.84

Non-coding RNAs in lung cancer. Oncoscience (2014) 0.83

Integration of CNS survival and differentiation by HIF2α. Cell Death Differ (2011) 0.83

Regulation of cell proliferation by hypoxia-inducible factors. Am J Physiol Cell Physiol (2015) 0.83

Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas (HNSCC). Exp Mol Pathol (2011) 0.83

A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator. Chem Biol Interact (2013) 0.82

Cell cycle progression in response to oxygen levels. Cell Mol Life Sci (2014) 0.82

Endothelin-1 promotes cardiomyocyte terminal differentiation in the developing heart via heightened DNA methylation. Int J Med Sci (2014) 0.81

YC-1 targeting of hypoxia-inducible factor-1α reduces RGC-5 cell viability and inhibits cell proliferation. Mol Vis (2012) 0.81

Interplay between p53 and VEGF: how to prevent the guardian from becoming a villain. Cell Death Differ (2013) 0.81

Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PLoS One (2016) 0.80

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest. Cell Death Dis (2014) 0.80

Molecular mechanisms of ischemic preconditioning in the kidney. Am J Physiol Renal Physiol (2015) 0.80

Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species. PLoS One (2015) 0.79

miR-497 expression, function and clinical application in cancer. Oncotarget (2016) 0.79

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun (2014) 0.79

Hypoxia-inducible factor-1α enhances the malignant phenotype of multicellular spheroid HeLa cells in vitro. Oncol Lett (2010) 0.79

Identifying Novel Transcriptional Regulators with Circadian Expression. Mol Cell Biol (2015) 0.79

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments. Nat Cell Biol (2017) 0.78

Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer. Oncotarget (2016) 0.78

Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol (2016) 0.78

Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer. Cancer Biol Ther (2015) 0.78

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer. BMC Cancer (2015) 0.78

Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha. Neurosci Lett (2009) 0.78

HIF-1 α had pivotal effects on downregulation of miR-210 decreasing viability and inducing apoptosis in hypoxic chondrocytes. ScientificWorldJournal (2014) 0.78

Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression. Cell Death Differ (2010) 0.78

Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Res (2015) 0.78

Serial expression of hypoxia inducible factor-1α and neuronal apoptosis in hippocampus of rats with chronic ischemic brain. J Korean Neurosurg Soc (2011) 0.77

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The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol (2006) 1.50

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A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. J Mol Med (Berl) (2012) 1.24

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