PubRank

G T Nepom

Author PubWeight™ 112.53‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen. J Clin Invest 1999 3.83
2 Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens. J Immunol 2001 2.12
3 Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med 1986 1.69
4 The molecular basis for HLA class II associations with rheumatoid arthritis. J Clin Immunol 1987 1.64
5 Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Genet Epidemiol 1991 1.60
6 Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing. J Clin Invest 1997 1.59
7 Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis. Diabetes Care 1999 1.52
8 The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules. J Exp Med 1984 1.51
9 Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest 1996 1.49
10 Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis. Arthritis Rheum 1991 1.48
11 HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation. J Immunol 1993 1.45
12 Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis. Lancet 1986 1.45
13 Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol 1996 1.41
14 Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity and HLA-D. Proc Natl Acad Sci U S A 1983 1.40
15 HLA-DQ molecules form alpha-beta heterodimers of mixed allotype. J Immunol 1988 1.37
16 Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis. J Clin Invest 1984 1.37
17 Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest 1998 1.33
18 An HLA-D region restriction fragment length polymorphism associated with celiac disease. J Exp Med 1986 1.32
19 Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene. Proc Natl Acad Sci U S A 1985 1.26
20 Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes. Diabetes 1987 1.25
21 An extended HLA-D region haplotype associated with celiac disease. Proc Natl Acad Sci U S A 1988 1.21
22 HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments. Ann Rheum Dis 1998 1.14
23 HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells. J Immunol 2000 1.14
24 Gene therapy in the treatment of autoimmune diseases. J Clin Invest 2000 1.14
25 Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol Cell Biol 1995 1.13
26 A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. Proc Natl Acad Sci U S A 1989 1.11
27 HLA-DQB1 codon 57 is critical for peptide binding and recognition. J Exp Med 1996 1.10
28 GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65. Diabetes 2000 1.10
29 Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome. J Clin Invest 1995 1.09
30 HLA-DQ polymorphisms are highly selective for peptide binding interactions. J Immunol 1995 1.07
31 Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response. J Immunol 2000 1.07
32 Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes. J Exp Med 1991 1.07
33 Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus. J Immunol 1998 1.05
34 Rapid epitope identification from complex class-II-restricted T-cell antigens. Trends Immunol 2001 1.04
35 Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin. Genes Immun 2010 1.04
36 Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J Clin Invest 1997 1.03
37 Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis. Proc Natl Acad Sci U S A 1990 1.03
38 Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset. Int Immunol 2001 1.02
39 Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice. Proc Natl Acad Sci U S A 1984 1.00
40 Immunization to a syngeneic sarcoma by a monoclonal auto-anti-idiotypic antibody. Nature 1983 1.00
41 Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR. J Immunol 1998 0.99
42 HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM. Diabetes 1990 0.97
43 Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition. J Exp Med 1990 0.97
44 Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity. Diabetologia 2008 0.97
45 Multiple Ia-like molecules characterize HLA-DR2-associated haplotypes which differ in HLA-D. Hum Immunol 1984 0.96
46 High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease. J Autoimmun 1997 0.95
47 Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules. Proc Natl Acad Sci U S A 1996 0.95
48 T cell selection and differential activation on structurally related HLA-DR4 ligands. J Immunol 2001 0.95
49 Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones. J Exp Med 1985 0.95
50 HLA-DR4-associated haplotypes are genotypically diverse within HLA. J Immunol 1985 0.94
51 Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer. Tissue Antigens 1999 0.93
52 Exon-specific oligonucleotide probes localize HLA-DQ beta allelic polymorphisms. Immunogenetics 1986 0.91
53 Six variants of HLA-B27 identified by isoelectric focusing. Immunogenetics 1986 0.90
54 HLA-DR antigens on lymphoid cells differ from those on myeloid cells. Nature 1983 0.90
55 A specific nucleotide sequence defines a functional T-cell recognition epitope shared by diverse HLA-DR specificities. Hum Immunol 1988 0.88
56 Alloreactive T-cell clones identify multiple HLA-DQw3 variants. Hum Immunol 1991 0.87
57 A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis. J Autoimmun 1996 0.87
58 Nonprogression of subclinical beta-cell dysfunction among first-degree relatives of IDDM patients. 5-yr follow-up of the Seattle Family Study. Diabetes 1990 0.87
59 Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome. J Exp Med 1994 0.87
60 Genetic and immunological markers of insulin dependent diabetes in Black Americans. Autoimmunity 1995 0.86
61 A real-time polymerase chain reaction assay for the rapid identification of the autoimmune disease-associated allele HLA-DQB1*0602. Tissue Antigens 2009 0.86
62 Tryptic peptide mapping identifies structural heterogeneity among six variants of HLA-B27. Immunogenetics 1986 0.85
63 A genetically controlled pairing anomaly between HLA-DQ alpha and HLA-DQ beta chains. J Immunol 1989 0.85
64 Suppressor mechanisms in tumor immunity. Experientia 1983 0.85
65 Promiscuous T-cell recognition of a rubella capsid protein epitope restricted by DRB1*0403 and DRB1*0901 molecules sharing an HLA DR supertype. Hum Immunol 1998 0.85
66 Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions. J Immunol 1996 0.85
67 ASHI Workshop Summary Report of the Science and Education Subcommittee: structural and functional relationships of human class II MHC molecules. Hum Immunol 1986 0.85
68 High genetic risk for IDDM in the Pacific Northwest. First report from the Washington State Diabetes Prediction Study. Diabetes 1994 0.84
69 HLA-DR class II associations with rubella vaccine-induced joint manifestations. J Infect Dis 1998 0.84
70 HLA-DP and HLA-DO genes in presumptive HLA-identical siblings: structural and functional identification of allelic variation. J Immunol 1987 0.82
71 Differential transcription elements direct expression of HLA-DQ genes. Clin Immunol Immunopathol 1995 0.82
72 Enhanced Detection of immunoglobulin binding by a modified ELISA. J Immunol Methods 1983 0.82
73 Molecular analysis of DQ beta 3.1 genes. Hum Immunol 1988 0.82
74 Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus. J Immunol 2000 0.82
75 Analysis of overlapping T- and B-cell antigenic sites on rubella virus E1 envelope protein. Influence of HLA-DR4 polymorphism on T-cell clonal recognition. Hum Immunol 1994 0.82
76 Autoreactive T cells from a type I diabetic recognize multiple class II products. Hum Immunol 1993 0.81
77 Allelic variation in transcription modulates MHC class II expression and function. Microbes Infect 1999 0.81
78 Conservation of the HLA-DQB2 locus in nonhuman primates. J Immunol 1992 0.81
79 CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles. J Immunol 1996 0.81
80 HLA class I and class II profiles of patients presenting with Sydenham's chorea. J Neurol 2000 0.81
81 Mutational analysis of the HLA-DQ3.2 insulin-dependent diabetes mellitus susceptibility gene. Proc Natl Acad Sci U S A 1989 0.81
82 HLA DQ beta 3.2 identifies subtypes of DR4+ haplotypes permissive for IDDM. Genet Epidemiol 1989 0.81
83 Analysis of HLA-DQA1 and -DQB1 genes in Mexican Americans with insulin-dependent diabetes mellitus. Tissue Antigens 1993 0.80
84 Antigen recognition. Curr Opin Immunol 2000 0.80
85 Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms. Proc Natl Acad Sci U S A 1996 0.80
86 Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes. Immunogenetics 1989 0.80
87 Characterization of specific HLA-DQ alpha allospecificities by genomic, biochemical, and serologic analysis. J Immunol 1987 0.80
88 Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes. J Immunol 1998 0.80
89 Low-dose streptozotocin induces sustained hyperglycemia in Macaca nemestrina. Autoimmunity 2001 0.79
90 The prevention of IDDM. Injecting insulin into the cytokine network. Diabetes 1995 0.79
91 Amino acids in the peptide-binding groove influence an antibody-defined, disease-associated HLA-DR epitope. Scand J Immunol 1994 0.79
92 Structural and functional constraints on HLA class II dimers implicated in susceptibility to insulin dependent diabetes mellitus. Baillieres Clin Endocrinol Metab 1991 0.78
93 Conservation of the HLA-DQB2 locus in nonhuman primates. J Immunol 1992 0.78
94 Monoclonal antibodies to cell surface antigens shared by chemically induced mouse bladder carcinomas. Cancer Res 1985 0.78
95 Further DNA sequence microheterogeneity of the HLA-DR4/Dw13 haplotype group: importance of amino acid position 86 of the DR beta 1 chain for T-cell recognition. Hum Immunol 1990 0.78
96 Differential expression of related HLA class II DQ beta genes caused by nucleotide variation in transcriptional regulatory elements. J Immunol 1992 0.78
97 Idiotypic interactions in immune responses to tumor-associated antigens. Biochim Biophys Acta 1986 0.78
98 Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box. Immunol Res 1993 0.78
99 Inherited diseases in North American Mennonites: focus on Old Colony (Chortitza) Mennonites. Am J Med Genet 1989 0.78
100 DNA restriction fragment length polymorphism of HLA-DR2: correlation with HLA-DR2-associated functions. J Neuroimmunol 1986 0.77
101 HLA heterozygosity in insulin-dependent diabetes is most frequent at the DQ locus. Scand J Immunol 1990 0.77
102 Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65. Autoimmunity 2001 0.77
103 Selective T-cell-receptor gene usage in allorecognition and graft-versus-host disease. Transplantation 1993 0.77
104 Analysis of differential HLA-DQB expression in autologous B cell lines. J Leukoc Biol 1993 0.77
105 Polyglot and polymorphism. An HLA update. Arthritis Rheum 1995 0.77
106 T-cell receptor V beta selectivity in T-cell clones alloreactive to HLA-Dw14. Hum Immunol 1992 0.77
107 MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition. Hum Immunol 1999 0.77
108 Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. J Rheumatol 1994 0.77
109 Radioimmunoassay for glutamic acid decarboxylase-65. Diabetes Technol Ther 1999 0.76
110 Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition. Hum Immunol 1999 0.76
111 MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments. Tissue Antigens 1997 0.75
112 Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer. Hum Immunol 2000 0.75
113 Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM. Hum Immunol 1998 0.75
114 Allele-specific DNA-protein interactions associated with the X-box regulatory region of the DQB1*0302 gene. Autoimmunity 1993 0.75
115 Electrophoretic variation between class II molecules expressed on HLA-DRw8 homozygous typing cells reveals multiple distinct haplotypes. Immunogenetics 1985 0.75
116 The effects of variations in human immune-response genes. N Engl J Med 1989 0.75
117 Functional polymorphisms among HLA-DR4+ DR beta chains associated with limited peptide diversity. Mol Immunol 1987 0.75
118 DQw3 variants defined by cloned alloreactive T cells. Hum Immunol 1988 0.75
119 Specific allelic variation among linked HLA class II genes. Transplantation 1987 0.75
120 HLA-DQ heterogeneity among HLA-DRw11(5) haplotypes. Tissue Antigens 1986 0.75
121 Induction of islet allotolerance in nonhuman primates. Ann N Y Acad Sci 2002 0.75
122 T cell autoreactivity in the transplant milieu. Am J Transplant 2012 0.75
123 Suppressor factors in tumor immunity. Transplant Proc 1984 0.75
124 Immunogenetics of disease susceptibility: new perspectives in HLA. Pathol Immunopathol Res 1986 0.75
125 Induction of donor-specific tolerance to islet allografts in nonhuman primates. Ann N Y Acad Sci 2002 0.75
126 Characterization of the HLA-restrictive elements of a rubella virus-specific cytotoxic T cell clone: influence of HLA-DR4 beta chain residue 74 polymorphism on antigenic peptide-T cell interaction. Int Immunol 1996 0.75
127 Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection. Rev Immunogenet 2000 0.75
128 HLA class II variants: structural studies and disease associations. Ann N Y Acad Sci 1986 0.75
129 Allorecognition of HLA-DQw8 molecules: influence of single amino acid substitutions. Tissue Antigens 1992 0.75
130 T-cell clones identify three distinct epitopes associated with HLA-Dw14. Hum Immunol 1991 0.75
131 Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis. Arthritis Rheum 1997 0.75
132 HLA class II typing using oligonucleotide probes. Genet Epidemiol 1989 0.75
133 Ultrastructural allelic variation in HLA-DQB1 promoter elements. Hum Immunol 1995 0.75
134 A deletion mutant defines DQ beta variants with DR4 positive DQw3 positive haplotypes. Hum Immunol 1986 0.75
135 Molecular biology of immune diseases and the immune response. Immunol Today 1990 0.75
136 Defective CD4+ T-lymphocyte reconstitution in major histocompatibility complex class II-deficient transplant models. Blood 1995 0.75