Published in Proc Natl Acad Sci U S A on November 01, 1983
Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc Natl Acad Sci U S A (1985) 2.19
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med (1986) 1.69
The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules. J Exp Med (1984) 1.51
Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis. J Clin Invest (1984) 1.37
Structural organization of the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1985) 1.34
Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene. Proc Natl Acad Sci U S A (1985) 1.26
Molecular localization and polymorphism of HLA class II restriction determinants defined by Mycobacterium leprae-reactive helper T cell clones from leprosy patients. J Exp Med (1986) 1.18
Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ. J Clin Invest (1987) 1.17
Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis. J Clin Invest (1986) 1.14
A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04. J Immunol Methods (2006) 1.04
Identification of a specific HLA DR2 Ia molecule as a restriction element for measles virus-specific HLA class II-restricted cytotoxic T cell clones. J Exp Med (1985) 0.95
Polymorphic restriction endonuclease sites linked to the HLA-DR alpha gene: localization and use as genetic markers of insulin-dependent diabetes. Proc Natl Acad Sci U S A (1985) 0.91
Evolutionary and genetic implications of sequence variation in two nonallelic HLA-DR beta-chain cDNA sequences. Proc Natl Acad Sci U S A (1987) 0.82
Unusual clustering of diseases in a Canadian Old Colony (Chortitza) Mennonite kindred and community. CMAJ (1988) 0.80
Human T-cell clones used to define functional epitopes on HLA class II molecules. Proc Natl Acad Sci U S A (1986) 0.76
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
High resolution two-dimensional electrophoresis of proteins. J Biol Chem (1975) 133.45
High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04
Two populations of Ia-like molecules on a human B cell line. J Immunol (1980) 7.68
Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci U S A (1971) 4.14
HLA-DR antigens: structure, separation of subpopulations, gene cloning and function. Immunol Rev (1982) 2.74
Demonstration of structural polymorphism among HLA-DR light chains by two-dimensional gel electrophoresis. J Exp Med (1980) 2.31
Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules. J Exp Med (1982) 2.15
Stable variants affecting B cell alloantigens in human lymphoid cells. Nature (1978) 2.07
Structural studies of murine I-E and human DR antigens. Mol Immunol (1979) 1.79
Characterization of HLA-D-region antigens by two-dimensional gel electrophoresis. Molecular-genotyping. J Exp Med (1980) 1.73
Five HLA-D clusters associated with HLA-DR4. Hum Immunol (1982) 1.70
Structural polymorphism of human DR antigens. Nature (1979) 1.63
Further characterization of HLA-DS molecules: implications for studies assessing the role of human Ia molecules in cell interactions and disease susceptibility. Proc Natl Acad Sci U S A (1983) 1.55
The serological recognition of the human MLC determinants using a modified cytotoxicity technique. Tissue Antigens (1975) 1.54
HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region. Nature (1982) 1.48
Analysis of HLA-DR antigens by using monoclonal antibodies: recognition of conformational differences in biosynthetic intermediates. J Immunol (1981) 1.44
Dw/LD-related molecular polymorphism of DR4 beta-chains. J Exp Med (1983) 1.42
Murine monoclonal antibodies against HLA structures. Immunol Rev (1979) 1.31
HLA-DR characterization of a Chippewa Indian subpopulation with high prevalence of rheumatoid arthritis. Hum Immunol (1981) 1.11
Detection of an altered I-A beta polypeptide in the murine Ir mutant, B6.C-h-2bm12. J Immunol (1982) 1.00
HLA antigens in Yakima Indians with rheumatoid arthritis. Lack of association with HLA-Dw4 and HLA-DR4. Arthritis Rheum (1982) 0.95
HLA-D clusters associated with DR4 in the Japanese population. Hum Immunol (1982) 0.93
Two distinct HLA-D specificities (DHO and Dw2) in linkage with HLA-DRw2 as defined in white and Japanese populations. Transplant Proc (1978) 0.90
New HLA-D alleles associated with DR1 and DR2. Tissue Antigens (1981) 0.86
Genetic evidence that HLA-DR (Ia) specificities include multiple HLA-D determinants on a single haplotype. Transplant Proc (1978) 0.85
HLA-D antigens in the Japanese population. Tissue Antigens (1977) 0.85
Analysis of the HLA-DRw8 haplotype: recognition by HTC typing of three distinct antigen complexes in Caucasians, Native Americans, and Orientals. Immunogenetics (1983) 0.85
Population data on two new HLA-D determinants, EI and RE. Scand J Immunol (1977) 0.84
HLA-D locus in Israel. Characterization of 14 local HTC's and a population study. Tissue Antigens (1982) 0.83
Linkage disequilibrium between HLA-B13 and HLA-D. Transplant Proc (1977) 0.82
Primary and secondary MLR characterization of three allelic variants of HLA-Dw7 segregating in a single family. Hum Immunol (1983) 0.82
Two homozygous typing cells defining a subgroup of HLA-Dw6. Hum Immunol (1980) 0.82
Population genetics for five HLA-D determinants in caucasians (New York City). Transplant Proc (1977) 0.79
Reanalysis of the HLA-DRw6 complex. Tissue Antigens (1983) 0.78
Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med (2001) 3.98
MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen. J Clin Invest (1999) 3.83
Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions. J Immunol (1983) 3.70
Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J Exp Med (1985) 3.48
Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood (1998) 3.06
Identification of a human T lymphocyte surface protein associated with the E-rosette receptor. J Exp Med (1981) 3.06
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci U S A (1990) 2.88
Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med (1993) 2.85
Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J Exp Med (1993) 2.71
Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med (1989) 2.61
Cell surface antigens of human melanoma identified by monoclonal antibody. Proc Natl Acad Sci U S A (1979) 2.40
HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum (1989) 2.28
Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction. Proc Natl Acad Sci U S A (1981) 2.16
The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1. J Immunol (1985) 2.14
Identification and functional characterization of two distinct epitopes on the human T cell surface protein Tp50. J Immunol (1983) 2.13
Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens. J Immunol (2001) 2.12
Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide. Blood (1994) 1.98
A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol (1986) 1.95
Maternal-fetal disparity in HLA class II alloantigens and the pregnancy-induced amelioration of rheumatoid arthritis. N Engl J Med (1993) 1.92
Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. Hum Immunol (1990) 1.91
Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. N Engl J Med (1983) 1.89
Nomenclature for factors of the HLA system, 2002. Tissue Antigens (2002) 1.89
Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J Immunol (1986) 1.89
Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood (1985) 1.81
Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease. Blood (1997) 1.80
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J Biol Chem (1998) 1.79
Hereditary C2 deficiency: Genetic studies and association with the HL-A system. J Exp Med (1975) 1.75
Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood (1995) 1.75
Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors. J Immunol (1983) 1.73
A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. J Clin Invest (1989) 1.72
Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition. Tissue Antigens (1999) 1.71
Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med (1986) 1.69
Quantitative determination of bone marrow transplant engraftment using fluorescent polymerase chain reaction primers for human identity markers. Blood (1995) 1.68
Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood (1997) 1.65
Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation. Blood (1997) 1.64
Fecundity before disease onset in women with rheumatoid arthritis. Arthritis Rheum (1993) 1.64
The molecular basis for HLA class II associations with rheumatoid arthritis. J Clin Immunol (1987) 1.64
Absence of monoclonal-antibody-defined protein complex in boy with abnormal leucocyte function. Lancet (1984) 1.63
Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Genet Epidemiol (1991) 1.60
Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing. J Clin Invest (1997) 1.59
Nomenclature for factors of the HLA system, 2004. Tissue Antigens (2005) 1.57
Linkage between the gene (or genes) controlling synthesis of the fourth component of complement and the major histocompatibility complex. N Engl J Med (1977) 1.55
NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis (1993) 1.54
Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes. J Clin Invest (1986) 1.53
Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis. Diabetes Care (1999) 1.52
Monoclonal antibody 9.3 and anti-CD11 antibodies define reciprocal subsets of lymphocytes. Eur J Immunol (1985) 1.51
The HLA-DR4 family of haplotypes consists of series of distinct DR and DS molecules. J Exp Med (1984) 1.51
Dw14(DRB1*0404) is a Dw4-dependent risk factor for rheumatoid arthritis. Rethinking the "shared epitope" hypothesis. Tissue Antigens (1991) 1.50
Rheumatoid factor, HLA-DR4, and allelic variants of DRB1 in women with recent-onset rheumatoid arthritis. Arthritis Rheum (1994) 1.49
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest (1996) 1.49
Association of HLA-Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the "shared epitope" hypothesis. Arthritis Rheum (1991) 1.48
Regulation of beta-cell mass by hormones and growth factors. Diabetes (2001) 1.46
In vitro regulation of immunoglobulin synthesis by T-cell subpopulations defined by a new human T-cell antigen (9.3). Cell Immunol (1982) 1.46
Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks. Tissue Antigens (2003) 1.46
HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation. J Immunol (1993) 1.45
Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis. Lancet (1986) 1.45
A new human T-cell differentiation antigen: unexpected expression on chronic lymphocytic leukemia cells. Immunogenetics (1980) 1.43
Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16). J Immunol (1987) 1.42
Monoclonal antibodies recognizing normal human T lymphocytes and malignant human B lymphocytes: a comparative study. J Immunol (1981) 1.41
Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol (1996) 1.41
Mixed lymphocyte culture determinants and C2 deficiency: LD-7a associated with C2 deficiency in four families. J Exp Med (1975) 1.40
Mixed leukocyte culture reactivity and graft-versus-host disease in HLA-identical marrow transplantation for leukemia. Bone Marrow Transplant (1992) 1.40
Nomenclature for factors of the HLA system, 1998. Tissue Antigens (1999) 1.40
T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets. Blood (1982) 1.39
Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood (1981) 1.39
Donor alloreactivity may predict acute graft-versus-host disease in patients receiving marrow transplants from HLA identical siblings. Bone Marrow Transplant (1992) 1.38
HLA-DQ molecules form alpha-beta heterodimers of mixed allotype. J Immunol (1988) 1.37
Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis. J Clin Invest (1984) 1.37
A model for disease heterogeneity in systemic lupus erythematosus. Relationships between histocompatibility antigens, autoantibodies, and lymphopenia or renal disease. Arthritis Rheum (1989) 1.37
A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment. Blood (1991) 1.35
Evidence for T cell nature and heterogeneity within natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) effectors: a comparison with cytolytic T lymphocytes (CTL). J Immunol (1981) 1.33
Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest (1998) 1.33
An HLA-D region restriction fragment length polymorphism associated with celiac disease. J Exp Med (1986) 1.32
The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood (1995) 1.31
Formation of polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells during consumption of charcoal-broiled beef. Carcinogenesis (1990) 1.31
Ecotaxis: the principle and its application to the study of Hodgkin's disease. Clin Exp Immunol (1977) 1.29
The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. Br J Haematol (2001) 1.28
Evaluation of a CD5-specific immunotoxin for treatment of acute graft-versus-host disease after allogeneic marrow transplantation. Blood (1996) 1.27
Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants. Bone Marrow Transplant (1988) 1.27